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Found 37 clinical trials
EGFR806 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults

This is a phase I, open-label, non-randomized study that will enroll pediatric and young adult research participants with relapsed or refractory non-CNS solid tumors to evaluate the safety, feasibility, and efficacy of administering T cell products derived from the research participant's blood that have been genetically modified to express a …

solid tumor
solid tumour
cellular therapy
biological factors
cytokine release syndrome
  • 484 views
  • 13 May, 2022
  • 1 location
B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults

This is a phase I, open-label, non-randomized study that will enroll pediatric and young adult research participants with relapsed or refractory non-CNS solid tumors to evaluate the safety, feasibility, and efficacy of administering T cell products derived from the research participant's blood that have been genetically modified to express a …

solid tumor
solid tumour
cellular therapy
biological factors
cytokine release syndrome
  • 39 views
  • 11 May, 2022
  • 1 location
Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms

The primary objective of this phase 1 trial is to determine the maximum tolerated dose (MTD), food effect, safety and tolerability of oral ONC206 in patients with recurrent, primary CNS neoplasms.

ependymoma
nitrosoureas
anaplastic oligodendroglioma
central nervous system tumor
oligodendroglioma
  • 10 views
  • 12 Mar, 2022
  • 1 location
SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors

Approximately 90% of children with malignant brain tumors that have recurred or relapsed after receiving conventional therapy will die of disease. Despite this terrible and frustrating outcome, continued treatment of this population remains fundamental to improving cure rates. Studying this relapsed population will help unearth clues to why conventional therapy …

sonidegib
gemcitabine
brain tumor
cancer
combinations
  • 224 views
  • 19 Apr, 2022
  • 1 location
Selpercatinib for the Treatment of Advanced Solid Tumors, Lymphomas, or Histiocytic Disorders With Activating RET Gene Alterations, a Pediatric MATCH Treatment Trial

This phase II pediatric MATCH trial studies how well selpercatinib works in treating patients with solid tumors that have spread to other places in the body (advanced), lymphomas, or histiocytic disorders that have activating RET gene alterations. Selpercatinib may block the growth of cancer cells that have specific genetic changes …

nitrosoureas
myelosuppressive chemotherapy
bone marrow procedure
pleural effusion
platelet count
  • 18 views
  • 25 Jul, 2022
  • 92 locations
Samotolisib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With TSC or PI3K/MTOR Mutations (A Pediatric MATCH Treatment Trial)

This phase II Pediatric MATCH trial studies how well samotolisib works in treating patients with solid tumors, non-Hodgkin lymphoma, or histiocytic disorders with TSC or PI3K/MTOR mutations that have spread to other places in the body (metastatic) and have come back (recurrent) or do not respond to treatment (refractory). Samotolisib …

epilepsy
myelosuppressive chemotherapy
platelet transfusion
platelet count
cancer treatment
  • 437 views
  • 24 Jul, 2022
  • 80 locations
Rhabdoid Tumors Cellular Architecture by Single-cell Analyses (InnovRT-2) (InnovRT-2)

The aim is to describe at the cellular level the heterogeneity of rhabdoid tumors, and identify how this diversity influences resistance to treatment.

  • 0 views
  • 25 Apr, 2022
  • 1 location
Study of Stored Tumor Samples in Young Patients With Brain Tumors

This laboratory study is looking at stored tumor samples in young patients with brain tumors. Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

  • 3 views
  • 24 Apr, 2022
  • 1 location
Molecular Basis of Pediatric Liver Cancer

The purpose of this retrospective and prospective project is to understand the molecular and genetic basis of liver cancer of childhood. Understanding the molecular and genetic bases of liver cancers can offer a better classification based on tumor biology, mechanisms and predisposition.

hepatoma
liver tumor
cancer
liver cancer
cancer, hepatocellular
  • 8 views
  • 09 May, 2022
  • 1 location
Rare CNS Tumors Outcomes &Risk

, including: Atypical teratoid rhabdoid tumor (ATRT); Brainstem and midline gliomas; Choroid plexus tumors; Ependymoma; High grade meningioma; Gliomatosis cerebri; Medulloblastoma; Oligodendroglioma

oligodendroglioma, anaplastic
ependymoma
cancer
atypical teratoid/rhabdoid tumor
pnet
  • 41 views
  • 28 Jul, 2022
  • 1 location