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Found 426 clinical trials
Macular Pigment Optical Density in Primary Angle-closure Disease

Glaucoma is the leading cause of irreversible blindness in the world, and primary angle-closure glaucoma (PACG) is the most important type of glaucoma in Asia. Primary angle closure disease (PACD) is a group of diseases related to PACG, and the pathogenesis is still unclear. Macular pigment has the functions of …

blindness
trabeculectomy
slit lamp examination
optical coherence tomography
glaucoma
  • 0 views
  • 10 Mar, 2022
  • 1 location
B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults

This is a phase I, open-label, non-randomized study that will enroll pediatric and young adult research participants with relapsed or refractory non-CNS solid tumors to evaluate the safety, feasibility, and efficacy of administering T cell products derived from the research participant's blood that have been genetically modified to express a …

cetuximab
chemotherapy regimen
biologic therapy
biologic agent
cancer chemotherapy
  • 39 views
  • 11 May, 2022
  • 1 location
Amblyopia and Strabismus Detection Using Retinal Birefringence Imaging (RBI)

The purpose of this project is to compare the accuracy of two products at detecting amblyopia and strabismus in children. The devices will be Rebiscan's "blinq" (Pediatric Vision Scanner; PVS) and Rebiscan's RBI (Retinal Birefringence Imager).

Accepts healthy volunteers
  • 0 views
  • 11 May, 2022
  • 1 location
Acceptability of Hybrid Closed-loop Systems in Patients Living With Highly Unbalanced Type 1 Diabetes (HCL-VHP)

While closed-loop insulin delivery (CLID) systems demonstrated safety and effectiveness in patients with unbalanced type 1 diabetes (T1D), no studies have included patients with highly and chronically unbalanced diabetes. The investigators conduct a retrospective, observational, and single-center study to evaluate the acceptability, safety, and efficacy of a CLID system in …

diabetes
continuous glucose monitoring
insulin
hemoglobin a1c
  • 0 views
  • 18 Apr, 2022
Distinguishing Participant Groups Using Autonomic Dysfunction

A study population with impaired fasting glucose levels, impaired glucose tolerance levels and diabetes (with or without complications) along with healthy patients will be chosen as participants. Their vital signs and their ECG (electrocardiograph) will be recorded during their only visit. Data analysis will be performed using the vital signs …

impaired glucose tolerance
body mass index
Accepts healthy volunteers
electrocardiogram
fasting
  • 0 views
  • 10 Jul, 2022
  • 1 location
The Natural History of Familial Dysautonomia

The study will collect clinical information from patients with FD and allow them to give blood to help develop biological markers of the disease to aid diagnosis and treatment. This is a non-invasive, non-interventional, observation study that poses only minimal risk for participants. The study will document the clinical features …

  • 63 views
  • 20 Apr, 2022
  • 2 locations
Molecular Analysis of Diabetic Kidney Disease Biopsies

Despite decades of research, the pathogenesis of human diabetic kidney disease remains largely unclear. Our goal is to use archived human kidney biopsy tissue from patients with and with diabetic nephropathy to identify new molecules that drive and/or protect against disease progression. We will use RNA sequencing to identify transcriptomic …

diabetes
nephropathy
glomerulosclerosis
kidney biopsy
diabetic nephropathy
  • 13 views
  • 13 Feb, 2022
  • 1 location
Screening Patients With Diabetes Mellitus for the Presence of Skin Disorder of Scleredema

Scleredema is a scleroderma-like skin disorder appearing in 2.5-14% among patients with type 1 or 2 diabetes mellitus. This is a single centre study to screen consecutive patients with diabetes mellitus for the presence of scleredema,and to compare the clinical-laboratory data of patients with and without scleredema. Metabolic and vascular …

diabetes
diabetes mellitus
  • 3 views
  • 03 Mar, 2022
  • 1 location
Neuroscience of Charles Bonnet Syndrome

Charles Bonnet Syndrome (CBS) is a condition in which people experience complex visual hallucinations, such as 'Acrobats balancing on bicycles' or 'Spiders crossing meals'. The condition usually occurs in people who have significant vision loss due to eye disease. The aim of this project is to help understand how these …

  • 0 views
  • 28 May, 2022
  • 1 location
Heidelberg Study on Diabetes and Complications (HEIST-DiC)

The prospective observational study entitled "Heidelberg Study on Diabetes and Complications" is designed to Monitor the presence and development of diabetic complications in type 1 and type 2 diabetic patients, as well as pre-diabetics. Mail Goal is to detect new metabolic mechanisms or new risk factors for the development of …

diabetes
cancer
hemoglobin a1c
plasma glucose
depression
  • 0 views
  • 24 Feb, 2022