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Found 452 clinical trials
Mobility Protocol Adapted for Advanced Visually Impaired Subjects

Retinitis Pigmentosa is characterized by a progressive disappearance of photoreceptors, responsible for a progressive and severe loss of vision. People Retinitis Pigmentosa therefore encounter a large number of difficulties in daily life, specifically for: Visual research Visuo-motor coordination in tasks requiring fine motor control Visuo-motor coordination in mobility tasks This …

low vision
  • 0 views
  • 24 Jan, 2021
  • 1 location
Interventional Study of Implantation of hESC-derived RPE in Patients With RP Due to Monogenic Mutation

Phase I/II open-label, safety, tolerability and preliminary efficacy study of implantation into one eye of hESC-derived RPE (Human Embryonic Stem Cell Derived Retinal Pigment Epithelium (RPE)) in patients with retinitis pigmentosa due to monogenic mutation. Study non randomized single group assignment consisting in 2 sequential cohorts of patients: First cohort …

genetic analysis
  • 0 views
  • 12 Jun, 2021
  • 1 location
A Natural History Study to Evaluate Functional and Anatomical Progression in Retinitis Pigmentosa

This study will assess the progression of RP as seen on newer modalities including spectral-domain optical coherence (SD-OCT) and macular assessment integrity (MAIA) microperimetry to evaluate disease status. Understanding the natural history of the disease is not only essential to monitoring and comparing patient populations in clinical trials. It is …

other disease
  • 0 views
  • 24 Sep, 2021
  • 1 location
Natural History Study of Retinitis Pigmentosa Type 11

Observational study of patients with retinitis pigmentosa type 11

  • 0 views
  • 27 Mar, 2021
  • 1 location
Natural History Study of Usher Syndrome ( Light4Deaf )

Clinical centres in the LIGHT4DEAF consortium have developed and will continue to improve a reliable, early molecular diagnosis and protocols for full clinical characterisation of Usher syndrome, which will be valuable for the foreseen USH clinical trials. The clinical arm of the project aims at performing a deep-phenotyping of retinal …

  • 0 views
  • 27 Jan, 2021
  • 4 locations
Ocular Changes in Vitiligo Patients on Therapy

Vitiligo patients on systemic and local therapy may have some ocular adverse effects associated with the disease and its therapy.

  • 0 views
  • 29 Apr, 2022
  • 1 location
Clinical Implication of Retinitis Pigmentosa Molecular Diagnostic Using High Throughput Sequencing. (RP-SEQ-HD)

The retinitis pigmentosa (RP) are genetic conditions that cause retinal degeneration leading to severe low vision and is the leading cause of consultation in reference centers dedicated to the ophthalmic genetics. These rare diseases are characterized by a triple heterogeneity (clinical, genetic and molecular), which made them unreachable by traditional …

other disease
Accepts healthy volunteers
retinal degeneration
electroretinogram
low vision
  • 317 views
  • 03 May, 2022
Efficiency of Intraoperative Optical Coherence Tomography (iOCT)

Efficiency of Intraoperative Optical Coherence Tomography (iOCT) Hypothesis The use of iOCT during surgery offers the advantage of a new view of the operating field, theoretically allows more precise performance and can also change decision-making mechanisms during surgery with more precise visual control of some surgical steps (incision adaptation, differentiation …

optical coherence tomography
glaucoma
primary open angle glaucoma
  • 0 views
  • 23 May, 2022
  • 1 location
A First-in-human, Proof of Concept Study of CPK850 in Patients With RLBP1 Retinitis Pigmentosa

The purpose of this first-in-human study is to explore the maximum tolerated dose (MTD) of CPK850 as determined by the single ascending dose ranging portion of the study. This study will also evaluate the safety and potential efficacy of CPK850 on improving visual function in patients with decreased visual function …

genetic testing
rod-cone dystrophy
genetic analysis
  • 467 views
  • 23 May, 2022
  • 1 location
A Study in Subjects With Retinitis Pigmentosa

An open-label Phase II clinical trial, 8 (eight) subjects with retinitis pigmentosa due to rhodopsin mutations (including P23H) will be identified and treated with serial intravitreal injections of ADX-2191 in the worse seeing eye. Ocular structure and function will be evaluated.

  • 0 views
  • 04 Jun, 2022
  • 1 location