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Found 445 clinical trials
A Study to Evaluate the Safety and Efficacy of RQC for AMD

To evaluate the safety and efficacy of resveratrol, quercetin, and curcumin in combination (RQC) over 2 years in patients with age-related macular degeneration (AMD).

drusen
geographic atrophy
atrophy
  • 0 views
  • 06 Oct, 2021
CNS10-NPC for the Treatment of RP

The investigator is examining the safety of transplanting cells into the subretinal space of patients with Retinitis Pigmentosa (RP). The cells are called neural progenitor cells, which are a type of stem cell that can become several different types of cells in the nervous system. These cells have been derived …

electroretinogram
  • 257 views
  • 28 Feb, 2022
  • 1 location
PDE6A Gene Therapy for Retinitis Pigmentosa

The PDE6A gene encodes a subunit of the rod phosphodiesterase. The loss of this enzyme function leads to a chronically elevated cGMP level which causes an increased calcium inflow into the cell and thereby the hyperactivation of cell death pathways. The goal of the PIGMENT study is to develop, produce …

other disease
gene therapy
  • 63 views
  • 26 Jan, 2021
  • 1 location
Topotecan Episcleral Plaque for Treatment of Retinoblastoma

This single site, single-arm, non-randomized, dose escalation phase I toxicity clinical trial will assess primarily the safety and secondarily the efficacy of episcleral topotecan in patients with active residual or recurrent intraocular retinoblastoma in at least one eye following completion of first-line therapy.

intraocular retinoblastoma
platelet count
topotecan
renal function
  • 118 views
  • 29 May, 2021
  • 1 location
Topotecan Episcleral Plaque for Treatment of Retinoblastoma

This single-arm, non-randomized, dose escalation phase I clinical trial will assess primarily the safety and secondarily the efficacy of episcleral topotecan in patients with active de novo or recurrent intraocular retinoblastoma in at least one eye following completion of first-line therapy.

calcium
neutrophil count
topotecan
platelet count
intraocular retinoblastoma
  • 0 views
  • 09 Oct, 2021
  • 2 locations
Protocol for the Study and Treatment of Participants With Intraocular Retinoblastoma

The primary objective of this protocol is to evaluate the response rate of bilateral disease participants who have at least one eye with advanced intra-ocular retinoblastoma (stratum B) using upfront therapy with chemotherapy delivered directly to the eye. The main biology objective is to improve our understanding of the biology …

doxorubicin
topotecan
vincristine
cyclophosphamide
nervous
  • 43 views
  • 28 Jun, 2022
  • 1 location
Factors Affecting Sensory and Motor Learning

How participants perceive the position of their own hand in various contexts will be examined. This will include changing the visual display to suggest the hand is in a slightly different position, and asking participants to indicate where they think it is by pointing with their other hand.

Accepts healthy volunteers
  • 0 views
  • 05 Jun, 2022
  • 1 location
Erythropoietin in Premature Infants to Prevent Encephalopathy

The main goal of this trial is to investigate whether early administration of human erythropoietin (EPO) in preterm infants improves neurodevelopmental outcome at 18 months corrected age. This study is designed as randomized, double-masked, placebo controlled multicenter study involving at least 312 patients.

  • 0 views
  • 22 Jan, 2022
  • 1 location
HCQ for Non Europeans With Mild to Severe UC

The objective of this study is to assess the efficacy of hydroxychloroquine (HCQ) when combined with Mesalamine in reducing clinical and histologic disease activity in patients who have active mild to severe Ulcerative Colitis (UC) and also to assess the immunological effects of hydroxychloroquine in this population. These outcomes will …

endoscopy
remission
hematochezia
mesalamine
  • 0 views
  • 22 Mar, 2022
  • 1 location
Corneal Nerves Function and Structure

Peripheral neuropathy affects about 50% of the diabetic population and there is no treatment other than good blood glucose control, which is ineffective in subjects with type 2 diabetes. Part of the problem for the lack of an effective treatment is the inability to detect peripheral neuropathy in its early …

Accepts healthy volunteers
  • 2 views
  • 27 May, 2022
  • 1 location