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Found 3567 clinical trials
A Study Evaluating the Efficacy and Safety of Ralinepag to Improve Treatment Outcomes in PAH Patients

Study ROR-PH-301, ADVANCE OUTCOMES, is designed to assess the efficacy and safety of ralinepag when added to pulmonary arterial hypertension (PAH) standard of care or PAH-specific background therapy in subjects with World Health Organization (WHO) Group 1 PAH.

diuretics
arginine
angiotensin
beta-blocker
right heart catheterization
  • 6444 views
  • 20 Jun, 2022
  • 226 locations
A Study of Ralinepag to Evaluate Effects on Exercise Capacity by CPET in Subjects With WHO Group 1 PH

Study ROR-PH-302, ADVANCE CAPACITY, is designed to evaluate the effects of ralinepag therapy on exercise capacity as assessed by change in peak oxygen consumption (VO2) derived from cardiopulmonary exercise testing (CPET) after 28 weeks of treatment

cardiopulmonary exercise testing
diuretics
stress test
ralinepag
endothelin
  • 0 views
  • 24 Nov, 2021
  • 34 locations
Leidos-Enabled Adaptive Protocol (LEAP-CT) for Evaluation of Post-exposure Prophylaxis for Newly-infected COVID-19 Patients (Addendum 2)

This study is designed to test the efficacy and safety of combinations of two well-understood agents - famotidine and celecoxib. Each of these agents separately demonstrate clinical activity in mitigating COVID-19 disease symptoms or severity, and each of which appear to have separate and complementary mechanisms of action.

  • 0 views
  • 16 Jun, 2022
  • 14 locations
Nasal Oxygen Therapy After Cardiac Surgery (NOTACS)

NOTACS aims to determine if prophylactic use of high-flow nasal therapy (for a minimum of 16 hours after tracheal extubation) increases days at home in the first 90 days after surgery, for adult patients undergoing cardiac surgery who are at high risk of postoperative pulmonary complications. The study also incorporates …

pulmonary disease
body mass index
  • 0 views
  • 08 Apr, 2022
  • 1 location
A Study in Participants With Sarcoidosis-associated Pulmonary Hypertension (SAPH) to Assess the Efficacy and Safety of Oral Selexipag (SPHINX)

Oral selexipag is commercially available in several countries for the treatment of a particular group of pulmonary hypertension (PH) called pulmonary arterial hypertension (PAH). The aim of the present study is to investigate whether selexipag could be helpful to treat patients with another form of PH called sarcoidosis-associated pulmonary hypertension …

  • 0 views
  • 09 Jun, 2022
  • 29 locations
Integrated Management of Chronic Respiratory Diseases (eMEUSE-SANTE)

Chronic respiratory diseases such as obstructive sleep apnea syndrome (OSA) and chronic obstructive pulmonary disease (COPD) constitute a major public health problem, due to their high

  • 0 views
  • 30 Jun, 2022
  • 1 location
Therapeutic Control of Aspirin-Exacerbated Respiratory Disease With Ifetroban

The overall aim of the study is to determine the efficacy of oral ifetroban, a novel antagonist of T prostanoid (TP) receptors, as a treatment for patients with aspirin-exacerbated respiratory

asthma
other disease
ifetroban
aspirin
polyposis
  • 27 views
  • 04 Mar, 2022
  • 1 location
The Efficiency of Chest Physiotherapy Applied in a Different Order

care unit where the study was conducted, the patients who have a respiratory disorder and receive supplemental oxygen therapy with non-invasive mechanical ventilation or an oxygen mask are first

  • 0 views
  • 15 Mar, 2022
Use of Hyperpolarized Xenon Gas for Lung Imaging in Children and Adults

The goal of this study is to evaluate the usefulness of hyperpolarized (HP) 129Xe (xenon) gas MRI for regional assessment of lung function in a normal population of children and adults and in adults and also in children with respiratory compromise due to a variety of diseases.

pulmonary function test
  • 0 views
  • 27 Jan, 2021
  • 1 location
Use of Hyperpolarized 129Xe MR Lung Imaging in Adults for Calibration

The goal of this study is to evaluate the usefulness of hyperpolarized (HP) 129Xe (xenon) gas MRI for regional assessment of lung function in a normal population of adults for the purposes of obtaining optimal images through MRI.

pulmonary function test
  • 0 views
  • 26 Jan, 2021
  • 1 location