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Found 3553 clinical trials
GI-101 as a Single Agent or in Combination With Pembrolizumab, Lenvatinib or Local Radiotherapy in Advanced Solid Tumors

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and therapeutic activity of GI-101 as a single agent or in combination with pembrolizumab, lenvatinib or local radiotherapy (RT) over a range of advanced and/or metastatic solid tumors.

lenvatinib
measurable disease
cancer chemotherapy
alopecia
pembrolizumab
  • 0 views
  • 02 May, 2022
  • 4 locations
Live Biotherapeutic Product MRx0518 and Pembrolizumab Combination Study in Solid Tumors

This is an open label, safety and preliminary efficacy study of MRx0518 in combination with pembrolizumab in patients with solid tumours (non small cell lung cancer, renal cell carcinoma, bladder cancer or melanoma). Subjects will be treated with IV pembrolizumab every 3 weeks and 1 capsule twice daily of MRx0518. …

lung cancer
measurable disease
solid tumour
programmed cell death 1 ligand 1
kidney cancer
  • 24 views
  • 06 Feb, 2022
  • 5 locations
Inovio TRT-001: Telomerase DNA Immunotherapy in Breast Lung and Pancreatic Cancers

This is a Phase I, open label study to evaluate the safety, tolerability, and immunogenicity of INO-1400 alone or in combination with INO-9012, delivered by electroporation in subjects with high risk breast, lung, or pancreatic cancer with no evidence of disease after surgery and adjuvant therapy. Subjects will be enrolled …

pancreatic cancers
adjuvant therapy
cancer
  • 72 views
  • 07 Nov, 2020
  • 3 locations
A Study of Ladiratuzumab Vedotin in Advanced Solid Tumors

This trial will study ladiratuzumab vedotin (LV) to find out if it works to treat different types of solid tumors. It will also find out what side effects may occur. A side effect is anything the drug does besides treating cancer.

measurable disease
solid tumors
chemoradiotherapy
adenocarcinoma
platinum-based chemotherapy
  • 13 views
  • 14 Jun, 2022
  • 64 locations
Study With Bispecific Antibody Engaging T-cells, in Patients With Progressive Cancer Diseases With Positive PSCA Marker

This dose-escalating phase I trial assesses for the first time the safety, the side effects and the harmlessness, as well as the therapeutical benefit of the new study drug GEM3PSCA in patients with prostate stem cell antigen (PSCA) expressing cancer types which failed to respond to standard therapy.

measurable disease
solid tumors
solid tumour
cancer
ejection fraction
  • 7 views
  • 03 Feb, 2022
  • 5 locations
A Study of SGN-B7H4V in Advanced Solid Tumors

This study will test the safety of a drug called SGN-B7H4V in participants with solid tumors. It will also study the side effects of this drug. A side effect is anything a drug does to the body besides treating the disease. Participants will have cancer that has spread in the …

lung cancer
measurable disease
endometrial carcinoma
ovarian epithelial carcinoma
squamous non-small cell lung cancer
  • 0 views
  • 15 May, 2022
  • 6 locations
HOPE-Genomics Intervention for the Improvement of Cancer Patient Knowledge of Genomics

This clinical trial studies the effectiveness of a web-based cancer education tool called Helping Oncology Patients Explore Genomics (HOPE-Genomics) in improving patient knowledge of personal genomic testing results and cancer and genomics in general. HOPE-Genomics is a web-based education tool that teaches cancer/leukemia patients, and patients who may be at …

cancer
  • 0 views
  • 25 Mar, 2022
  • 1 location
Study of XB002 in Subjects With Solid Tumors (JEWEL-101)

This is a Phase 1, non-randomized, open-label, multicenter, dose-escalation and expansion study evaluating the safety, tolerability, PK, pharmacodynamics, and clinical antitumor activity of XB002 administered IV q3w alone and in combination with nivolumab to subjects with advanced solid tumors.

measurable disease
adenocarcinoma
EGFR
epidermal growth factor receptor
ovarian epithelial carcinoma
  • 0 views
  • 23 May, 2022
  • 5 locations
ADP-A2M4CD8 as Monotherapy or in Combination With Nivolumab in HLA-A2+ Subjects With MAGE-A4 Positive Tumors (SURPASS)

This study will investigate the safety and tolerability of ADP-A2M4CD8 T-cell therapy in subjects who have the appropriate human leukocyte antigen (HLA) and MAGE-A4 tumor antigen. Tumor indications include endometrial, esophageal, esophagogastric junction (EGJ), gastric, head and neck, melanoma, non-small cell lung (NSCLC), ovarian or urothelial cancer.

oximetry
measurable disease
gastric cancer
carcinoma
esophagus cancer
  • 14 views
  • 14 Jun, 2022
  • 15 locations
A Study of SGN-ALPV in Advanced Solid Tumors

This study will test the safety of a drug called SGN-ALPV in participants with solid tumors. It will also study the side effects of this drug. A side effect is anything a drug does to your body besides treating your disease. Participants will have solid tumor cancer that has spread …

measurable disease
line of therapy
endometrial carcinoma
germ cell tumor
metastatic gastric cancer
  • 0 views
  • 03 Jun, 2022
  • 4 locations