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Found 11 clinical trials
Bolus Versus Continuous Infusion of Meropenem (MERCY)

This study arises from the need to optimize antibacterial drug usage to face increasing drug resistance among gram-negative pathogens in intensive care units. Gram-negative organisms are responsible for 70% of drug-resistant infections acquired in the intensive care unit. Meropenem is a β-lactam, carbapenem, antibacterial agent usually administered by intermittent infusion. …

  • 30 Jun, 2022
  • 23 locations
Bismuth Subsalicylate's Role in the Prevention of Travelers' Diarrhea

The purpose of this study is to determine if the use of prophylactic bismuth subsalicylate (BSS) has an effect on the acquisition of travelers' diarrhea (TD) or antimicrobial resistance (AMR) genes in fecal samples among international travelers who departed from the United States to South East Asia, South Central Asia, …

Accepts healthy volunteers
  • 10 Mar, 2022
  • 1 location
FMT for MDRO Colonization After Infection in Renal Transplant Recipients (PREMIX)

Transplant patients are at increased risk of colonization and infection with Multidrug Resistant Organisms (MDROs) due to medications that modify their immune systems, increased healthcare and antibiotic exposure, and surgical manipulation of mucosa. In this study, kidney transplant patients who have infections with resistant bacteria will be given a Fecal …

  • 27 Jan, 2022
  • 1 location
Imipenem/Cilastatin/Relebactam (IMI/REL) in Treatment of CRE Infections

This is an observation study comparing prospective use of Imipenem/Cilastatin/Relebactam (IMI/REL) to retrospective data using Meropenem/Vabobactam (MVB)and Ceftazidime/Avibactam CZA) in treatment of Klebsiella Producing Carbapenemase Enterobacteriaceae infections at a tertiary care hospital. The objectives of the study are to demonstrate successful treatment of KPC containing Enterobacteriaceae infections with IMI/REL including …

  • 02 Jul, 2022
  • 1 location
Optimized Perioperative Antibiotic Prophylaxis in Radical Cystectomy (PAPRAC)

Cystectomy with urinary diversion (ileal conduit, orthotopic ileal bladder substitute, continent catheterizable pouch) is the best treatment option for patients with muscle-invasive bladder cancer. This intervention is one of the most challenging in urology and has a high rate of postoperative complications including around 30% of postoperative infections. Perioperative antibiotic …

surgical site infections
antibiotic prophylaxis
abdomen surgery
invasive bladder cancer
  • 03 Mar, 2022
  • 2 locations
Inulin for Infections in the Intensive Care Unit

Normal gut bacteria prevent colonization and subsequent infection with MDR organisms (MDROs) through competition for resources and other mechanisms. During critical illness, this function of the microbiome is lost and there are no current treatments to restore it. Preliminary data indicates that the prebiotic fiber inulin is safe and may …

  • 27 Jan, 2021
  • 1 location
Safety and Efficacy of Fecal Microbiota Transplantation

The gut microbiota is critical to health and functions with a level of complexity comparable to that of an organ system. Dysbiosis, or alterations of this gut microbiota ecology, have been implicated in a number of disease states. Fecal microbiota transplantation (FMT), defined as infusion of feces from healthy donors …

disease or disorder
  • 23 Mar, 2022
  • 1 location
The Impact of Covid-19 Hospital Care on the Prevalence of MDRO in Indonesia

The effect of the COVID-19 pandemic on the emergence and spread of antibiotic-resistant bacteria is largely unknown, especially in low-resource settings. We aim to investigate the prevalence and relatedness of multidrug-resistant bacteria among patients in both COVID-19 and non-COVID-19 wards in two hospitals in Indonesia. Bacterial isolates will be collected …

  • 07 Apr, 2022
Antibiotic Stewardship Program in Pancreatic Surgery: a Multicenter Time Series Analysis (BIOSTEPS). (BIOSTEPS)

Rationale: Surgical site infection (SSI) is one of the most frequently reported postoperative complication, occurring in up to one-third of patients. Its development causes a substantial increase in the clinical and economic burden of pancreatic surgery. Nowadays, the primary goal of a surgical department is the reduction of the SSI …

site infection
antibiotic prophylaxis
postoperative complication
antibiotic therapy
  • 27 Feb, 2022
  • 1 location
Comprehensive Molecular Diagnosis and Management of Hospital- and Ventilator-associated Pneumonia in Norway

HVAPNOR consists of Three work packages: Prospective observational study of Hospital (HAP) - and ventilator-Associated pneumonia (VAP) at 5 hospitals in Norway. Establish optimized routines for microbiological sampling, diagnostics and antibiotic stewardship.. Biomarker studies in HAP and VAP. Studies on capacity building in HAP and VAP diagnostics.

  • 13 Dec, 2021
  • 1 location