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Found 106 clinical trials
Intravenous Amino Acid Therapy for Kidney Protection in Cardiac Surgery. (PROTection)

development by decreasing renal perfusion through a reduction in renal blood flow and through the activation of the sympathetic nervous system and the renin-angiotensin system with afferent arteriolar

crystalloid solutions
kidney injury
acute renal failure
continuous infusion
critical illness
  • 1 views
  • 02 Jul, 2022
  • 12 locations
A Study to Learn More About How Well the Study Treatment Finerenone Works, How Safe it is, How it Moves Into, Through, and Out of the Body, and the Effects it Has on the Body When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker in Children With Chronic Kidney Disease and Proteinuria (FIONA)

and/or proteinuria. These include "angiotensin-converting enzyme inhibitors" (ACEI) and "angiotensin receptor blockers" (ARB). Both ACEI and ARB can improve kidney function by helping the renin

aldosterone
angiotensin
chronic kidney disease
renin
hypertension
  • 0 views
  • 02 Jul, 2022
  • 10 locations
GOREISAN for Heart Failure (GOREISAN-HF) Trial (GOREISAN-HF)

The objective of the GOREISAN-HF trial is to assess the effect of the administration of Goreisan (TJ-17) plus standard therapy compared to standard therapy alone on the improvement rate of cardiac edema and clinical outcomes in worsening congestive heart failure with volume overload.

edema
b-type natriuretic peptide
heart failure
congestion
pulmonary congestion
  • 2 views
  • 27 Apr, 2022
  • 1 location
Study of the Safety and Efficacy of OMS721 in Patients With Immunoglobulin A (IgA) Nephropathy

The purpose of this study is to evaluate the safety and efficacy of OMS721 in patients with IgA nephropathy. The study will assess proteinuria by 24-hour urine protein excretion (UPE) in g/day at 36 weeks from beginning of treatment.

immunoglobulin a
glomerular filtration rate
proteinuria
immunoglobulins
nephropathy
  • 486 views
  • 05 Mar, 2022
  • 30 locations
Atrasentan in Patients With IgA Nephropathy (ALIGN)

The ALIGN Study is a phase 3, double-blind, placebo-controlled study to compare the efficacy and safety of atrasentan to placebo in patients with IgA nephropathy (IgAN) at risk of progressive loss of renal function.

renal function
nephropathy
  • 33 views
  • 17 Jun, 2022
  • 119 locations
Drug-Targeted Alerts for Acute Kidney Injury

In this trial, patients with acute kidney injury who have recently received a drug that may affect kidney function will be randomized to having an alert placed in the electronic health record or usual care.

aldosterone
renal injury
nephropathy
  • 0 views
  • 16 Oct, 2021
Management of Angiotensin Inhibitors During the Perioperative Period (AIPOP)

This is a multicenter randomized clinical trial to determine the effect of continuation versus withdrawal of angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) in the perioperative period on postoperative complications.

hypertension
postoperative complication
  • 0 views
  • 22 Mar, 2022
  • 6 locations
Pentoxifylline in Diabetic Kidney Disease (PTXRx)

Pentoxifylline (PTX) is a medication that has been on the market since 1984 for use in disease in the blood vessels of the legs. There is some preliminary information that it may protect the kidneys from damage due to diabetes and other diseases. "Pentoxifylline in Diabetic Kidney Disease" is a …

nephropathy
diabetes
pentoxifylline
diabetic nephropathy
  • 42 views
  • 20 Jun, 2022
  • 16 locations
Low vs. Moderate to High Dose Vitamin D for Prevention of COVID-19

The purpose of this study is to compare the risks of COVID-19 in individuals from Chicagoland communities randomized to low (400 IU/day) vs. moderate (4,000 IU/day) or high (10,000 IU/day) dose vitamin D.

  • 0 views
  • 11 May, 2021
  • 2 locations
Occurrence of Dyskalemia With Treatment for Hypertension (OK)

Hypertension is a major public health issue associated with significant morbidities and mortality. Fixed-dose combination (FDC) pills, combining 2 or more classes of antihypertensive medications have considerable appeal because these drugs may reduce blood pressure more effectively and efficiently compared to monotherapy. However, because FDC medication causes 'dyskalemia', the occurrence …

amlodipine 5 mg
amlodipine
telmisartan
blood pressure diastolic
systolic blood pressure
  • 0 views
  • 24 Mar, 2022
  • 1 location