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Found 108 clinical trials
Association Between a Multi-Gene Panel and Renal Denervation Effectiveness in Patients With Hypertension (GxRDxHTN)

The purpose of this study is to assess the effectiveness of a multi-gene panel to determine which subjects are likely to respond to renal denervation therapy with Medtronic's Symplicity Spyral™ multi-electrode renal denervation system.

hypertension
  • 0 views
  • 21 Mar, 2022
  • 1 location
Cerebrovascular Reactivity in Alzheimer's Disease (VARAD-ET)

The etiology of Alzheimer's disease (AD), the most common type of dementia, remains largely undefined and the early diagnostic and effective treatments are still not available. In addition to the neuropathological hallmarks, cerebrovascular dysfunction has been identified as an important component of AD. Using the experimental models, we showed that …

cognitive impairment
neuropsychological test
alzheimer's disease
dementia
  • 1 views
  • 24 Feb, 2022
  • 1 location
Prospective Phenotyping of Autonomous Aldosterone Secretion

This prospective cohort study will investigate the physiology and progression of autonomous aldosterone secretion.

Accepts healthy volunteers
  • 0 views
  • 05 Mar, 2022
From Micro- to Macro-vessels : Water, Salt, Heart and Kidneys

Hypertension is a public health concern and affects nearly a third of the French population. It can be complicated by visceral impact (including brain, heart and kidney complications) as well as on vessels especially large arteries, responsible for arterial stiffening. There are close interactions between heart and kidneys, as well …

hypertension
stroke
renin
stiffness
fasting
  • 0 views
  • 28 Dec, 2021
  • 1 location
LOnger-term Effects of COVID-19 INfection on Blood Vessels And Blood pRessure (LOCHINVAR) (LOCHINVAR)

The COVID-19 pandemic is the biggest medical challenge in decades. Individuals with pre-existing cardiovascular diseases have a higher risk of severe disease and death from COVID-19. The SARS-CoV-2 virus causes infection by targeting a molecule on the walls of the cells lining the lungs and the blood vessels leading to …

hypertension
stroke
electrocardiogram
antihypertensive drugs
hbpm
  • 8 views
  • 13 May, 2022
  • 1 location
Endothelial Function Inflammation and Organ Dysfunction in COVID-19

COVID-19 is a rapidly evolving pandemic with approximately 5% of all patients which require intensive care unit admission. In critically ill patients infected with COVID-19, approximately 15% had severe shock requiring medications to increase blood pressure. It appears that blood vessel tone is altered and microcirculation is not well regulated …

  • 0 views
  • 16 Aug, 2021
  • 1 location
Point of Care Ultrasound Measurements of Perioperative Edema in Infants With Congenital Heart Disease

Babies can be born with heart problems and sometimes need a heart surgery to fix the heart problem. Heart surgery can cause swelling from the build-up of extra fluid. Swelling can make it harder for babies to breath and has to be treated with medicine called diuretics. Swelling is hard …

cardiopulmonary bypass
Accepts healthy volunteers
congenital heart defects
edema
diuretics
  • 0 views
  • 18 Feb, 2022
  • 1 location
Transformative Research in Diabetic Nephropathy (TRIDENT)

This is a prospective, observational, cohort study of patients with a clinical diagnosis of diabetes who are undergoing clinically indicated kidney biopsy. The intent is to collect, process, and study kidney tissue and to harvest blood, urine and genetic materials to elucidate molecular pathways and link them to biomarkers that …

diabetic nephropathy
nephropathy
diabetes
kidney biopsy
  • 410 views
  • 27 Jan, 2022
  • 17 locations