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Found 298 clinical trials
Tranexamic Acid for Acute Upper Gastrointestinal Bleed in Cirrhosis

The management of acute upper gastrointestinal bleeding (UGIB) is challenging in patients with cirrhosis, as it is responsible for severe complications and high mortality rates. Fibrinolytic activity of the epithelial surfaces and of the submucosal blood vessels may interfere with hematemesis and even delay healing of ulcers. Tranexamic acid (TXA) …

  • 26 Jan, 2021
  • 1 location
Re-EValuating the Inhibition of Stress Erosions (REVISE) Trial

Patients who are critically ill in the in the Intensive Care Unit (ICU), especially those who need a breathing machine, can develop ulcers in the stomach that bleed. To prevent bleeding, many such patients around the world receive a drug called pantoprazole that decreases acid production. However, today, compared to …

  • 24 Jan, 2021
  • 36 locations
Antibiotic Prophylaxis in Patients Undergoing Elective TKA- Multi-center Trial

The Antibiotic Prophylaxis in Patients Undergoing Elective Total Knee Arthroplasty (TKA): Multi-Center Trial is a study that will compare the effectiveness of various perioperative strategies for antibiotic delivery as prophylaxis for periprosthetic joint infections (PJI) and surgical site infection in elective primary TKA. The investigators hypothesize that a single dose …

total knee replacement
inflammatory arthritis
  • 23 Jul, 2021
  • 20 locations
Preventing Acute Kidney Injury (AKI) in Neonates

function and the attenuation of renal injury in newborns, and young infants following cardiac palliative/correction surgery. The study rationale is Aminophylline and theophylline are competitive non

  • 23 Jan, 2021
  • 1 location
Anesthesia and Acute Kidney Injury After Nephrectomy

This study investigates the influence of type of anesthesia on postoperative renal dysfunction in patients undergoing nephrectomy. The participants will be allocated to either the group receiving the total intravenous anesthesia (TIVA) using propofol or the group receiving the inhaled anesthetics using desflurane.

  • 25 Jan, 2021
Angiotensin in Septic Kidney Injury Trial

The purpose of this study is to determine the effect of a systemic infusion of angiotensin II on haemodynamics and urine output in critically ill patients with severe sepsis/septic shock and acute renal failure. It will also help determine the feasibility of conducting a definitive and adequately powered randomised controlled …

renal replacement
angiotensin ii
critical illness
renal failure
  • 07 Nov, 2020
  • 2 locations
Prevention of Akute Kidney Injury Hearttransplant ANP

Prospective, blinded, placebo-controlled trial. Patients: Adult patients (>18 years of age) undergoing de novo Htx, with a preoperative GFR > 30ml/min, not receiving an ABO-incompatible organ with an ischemia time of > 6 hours. A donor age > 70 years is an exclusion criteria. Intervention: Infusion of h-ANP fore five …

renal injury
  • 19 Mar, 2021
  • 1 location
Protection From Acute Kidney Injury (AKI) With Basis Treatment

Riboside and Pterostilbene) in preventing acute kidney injury (AKI) in patients undergoing complex aortic aneurysm repair and open aortic arch reconstruction.

renal injury
  • 12 Jun, 2021
  • 1 location
DyeVert System and Contrast-induced Acute Kidney Injury

The aim of the REnal Insufficiency Following Contrast MEDIA Administration TriaL IV (REMEDIAL IV) is to test whether the use of the DyeVert system is effective in reducing CI-AKI rate in ACS patients undergoing urgent/immediate (within 2 hours) invasive diagnostic and/or interventional cardiovascular procedures. The DyeVert system (Osprey Medical Inc., …

  • 03 Feb, 2021
  • 2 locations
Coronavirus Induced Acute Kidney Injury: Prevention Using Urine Alkalinization

Our overarching goal is to improve the outcomes of critically ill COVID-19 patients with or at risk for development of acute kidney injury (AKI). The objective of this study is to determine the

critical illness
renal injury
coronavirus infection
  • 29 Apr, 2021
  • 1 location