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Found 19 clinical trials
TAS102 in Patients With ER-positive HER2-negative Advanced Breast Cancer

This is a multicenter phase 2 study evaluating the efficacy and safety of trifluridine/tipiracil in women with metastatic or locally advanced breast cancer not amenable to curative treatment by surgery or radiotherapy.

locally advanced breast cancer
taxane
erbb2
HER2
capecitabine
  • 0 views
  • 28 May, 2021
  • 10 locations
Efficacy and Safety of Dabigatran in Patients With Cirrhosis and Portal Vein Thrombosis

A randomized controlled trial to study the efficacy and safety of Dabigatran in Cirrhotic patients who develop PVT.In this study the patients who meet the inclusion criteria will be randomized to either receive Dabigatran or placebo [multivitamin tablet]. Blood samples will be taken &Imaging will be done accordingly to notice …

cirrhosis
portal vein thrombosis
  • 20 views
  • 25 Jan, 2021
  • 1 location
Incretin and Treatment With Inhibition of Sodium-glucose Cotransporter-2 Combination Insights Into Mechanisms Implicated in Congestive Heart Failure: "NATRIURETIC" Trial

This study aims to provide essential mechanistic insights into natriuretic and hemodynamic effects of SGLT2i and GLP-1RA agents in T2D patients. Ultimately, by obtaining physiological data in T2D patients without HF, our aims are to gain insight into how the use of this combined therapy may be used in T2D …

body mass index
hemoglobin a1c
ace inhibitor
liraglutide
  • 0 views
  • 25 Jan, 2021
  • 1 location
Pre-emptive Dexamethasone in Hip Arthroplasty

Certain studies suggested that preoperative administration of systemic glucocorticoids in patients undergoing hip or knee arthroplasty surgery may improve the postoperative analgesia owing to their anti-inflammatory effect. This study will be carried out on 70 adult patients aged 21 to 75 years admitted to orthopedic operating rooms in Tanta university …

pain relieving
morphine
anesthesia
dexamethasone
postoperative pain
  • 0 views
  • 17 Jun, 2021
  • 1 location
Perioperative Therapy Preoperative Chemotherapy Versus Chemoradiotherapy in Locally Advanced Gall Bladder Cancers

Locally advanced Gall bladders cancers not amenable for curative resection are often treated with chemotherapy alone which is the current standard of care. Randomized trials have shown survival benefit with combination chemotherapy in gallbladder cancers. Gallbladder cancer is not common western world and thus there is lack of evidence regarding …

jaundice
gemcitabine/cisplatin
serum bilirubin
metastasis
adenocarcinoma
  • 38 views
  • 22 Jan, 2021
  • 1 location
Comparison of Bovine Colostrum Versus Placebo in Treatment of Severe Alcoholic Hepatitis: A Randomized Double Blind Controlled Trial

Severe Alcoholic hepatitis, defined by modified Maddrey's Discriminant Function (DF) 32, is associated with significant morbidity and mortality.(1,2) Of the various treatment modalities evaluated for treatment of Severe Alcoholic hepatitis, corticosteroids have been the most extensively studied.(1) Five out of 13 randomized controlled trials, and four out of 5 meta-analysis …

encephalopathy
steroid therapy
jaundice
n-acetylcysteine
gastrointestinal bleeding
  • 5 views
  • 05 May, 2021
  • 1 location
Personalization of AntiTB Treatment: Evaluation of Pharmacological Determinants of Treatment Response

The aim of the study is to investigate the possible correlation of plasma drug concentrations with Time To Positivity (TTP) in liquid culture in patients with active pulmonary multi sensitive TB in the first two weeks of treatment. Secondary aims are: the correlation between plasma drug concentrations and hepato/neuro toxicity; …

spots
sputum microscopy
  • 0 views
  • 23 Jan, 2021
  • 1 location
Vicente Ferrer HIV Cohort Study

The VFHCS is a long-term prospective cohort study of HIV infected patients from a resource-poor rural setting in India. The aim of the study is to use data collected from routine clinical care in order to describe the epidemiology of HIV and its related conditions in the investigators area, and …

HIV Vaccine
  • 76 views
  • 21 Mar, 2021
  • 1 location
Cutaneous Denervation in Alcoholic Neuropathy

Peripheral neuropathy is a frequent neurological complication of chronic alcoholism. Most studies evaluated large-fiber involvement by nerve conduction studies (NCS). Since previous studies document the predominant injury of small myelinated and unmyelinated fibers in patients with alcoholic neuropathy, it will be imperative to know their prevalence and clinical significance. Moreover, …

peripheral nerve disease
alcoholism
skin biopsy
nerve conduction
protein gene product
  • 99 views
  • 07 Nov, 2020
  • 1 location