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Found 1543 clinical trials
Diastolic Dysfunction and Pauci-inflammatory Acute Exacerbations of COPD

This is a prospective study to determine the relationships between pauci-inflammatory exacerbations and diastolic dysfunction, and their implications in hospitalized patients with acute exacerbations of COPD. To assess changes within subjects from stable to acute phase, a number of comparisons will be made in subjects enrolled during acute exacerbation with …

acute exacerbation of copd
acute exacerbation of chronic obstructive pulmonary disease
  • 24 Jan, 2021
  • 1 location
Quality of Life in Pancreas Transplantation

Quality of Life for individuals with Insulin Dependent Diabetes Mellitus (IDDM) can be severely impaired by acute and chronic complications of the disease. Solid organ pancreatic transplantation restores endocrine pancreatic function. However, it is also burdened by high perioperative morbidity and mortality. Clinical benefits and risks of this intervention have …

type 2 diabetes mellitus
diabetes mellitus
  • 22 Jan, 2021
  • 1 location
A Causative Role for Amylin in Diabetic Peripheral Neuropathy

Three pieces of information lead to the basis for this study: Individuals with Type-2 diabetes commonly develop peripheral neuropathy. Increased production of the hormone amylin occurs in individuals who have Type-2 diabetes. Aggregations of amylin was found in the peripheral vasculature of rats that overexpressed human amylin. The purpose of …

diabetic peripheral neuropathy
nerve conduction
  • 03 May, 2021
  • 2 locations
DNA Methylation Analysis in Acute Coronary Syndrome and Atrial Fibrillation: DIANA Clinical Trial

Although epigenetics has been identified as one of the most relevant pathophysiological components in the development of cardiovascular diseases, there is still considerable difficulty in finding markers of epigenetic damage useful in clinical practice. Moreover, these markers could be useful to predict the onset and severity of disease as well …

myocardial infarction
unstable angina
cardiovascular disease
  • 22 Mar, 2021
  • 1 location
Screening Patients With Diabetes Mellitus for the Presence of Skin Disorder of Scleredema

Scleredema is a scleroderma-like skin disorder appearing in 2.5-14% among patients with type 1 or 2 diabetes mellitus. This is a single centre study to screen consecutive patients with diabetes mellitus for the presence of scleredema,and to compare the clinical-laboratory data of patients with and without scleredema. Metabolic and vascular …

diabetes mellitus
  • 24 Jan, 2021
  • 4 locations
Mitochondrial DNA in Vitreous Fluid and Blood in Patients With Eye Disease or Ocular Trauma.

This study is to characterize mitochondrial DNA (mtDNA) populations in adults with eye injuries and eye diseases. The eye exam is often hindered by the clouding of tissues involved in injury or disease. This protocol examines the use of mtDNA populations as indicators of developing inflammation and resolution of injury. …

eye exam
eye disease
mitochondrial dna
eye disorder
  • 18 Apr, 2021
  • 1 location
The Use of a Dynamic Sustained Compression Intramedullary Nail for Tibiotalocalcaneal Arthrodesis

The purpose of this study is to determine the clinical efficacy of a novel sustained dynamic compression intramedullary nail for tibiotalocalcaneal (TTC) arthrodesis utilizing longitudinal weight-bearing computed tomographic imaging. Of particular focus will be assessment of compressive element recovery and its relation to fusion development over time and weight-bearing status. …

  • 20 Apr, 2021
  • 1 location
Kidney in Coronavirus Disease 2019 Registry

The SARS-CoV-2 virus is a virus newly identified in January 2020. The WHO defined COVID-19 as a health emergency of international importance. The clinical manifestation of the COVID-19 disease cannot be fully described in the short time. First insights in patients suffering from acute kidney injury (AKI) during COVID-19 indicate …

  • 24 Mar, 2021
  • 1 location
APL-501 Study for Select Advanced or Relapsed/Recurrent Solid Tumors

The purpose of this study is to determine the safety, tolerability, and recommended dose schedule of APL-501 in individuals with advanced or relapsed or recurrent solid tumors.

metastatic cancer
solid tumour
adenocarcinoma of the gastroesophageal junction
measurable disease
  • 25 Jan, 2021
  • 6 locations
Genomic Testing and Resulting Medical Decisions

There is no evidence available about which molecular profiling methods are currently used for cancer patients in Austrian clinical practice. The construction of the registry proposed as a completely independent research endeavor, will be helpful for scientific evaluation and the establishment of highly credible data.

breast lymphoma
  • 24 Jan, 2021
  • 6 locations