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Found 36 clinical trials
Contrast Enhanced Ultrasonography to Detect Human Renal Transplant Rejection

The purpose of this study is to determine the feasibility and efficacy of detecting kidney transplant rejection using contrast enhance ultrasonography with the contrast agent Sonazoid.

kidney transplant
  • 16 views
  • 04 Mar, 2022
Clinical Impact of the iBox as an Early Intervention tooL (CIBIL)

International, multicentre, randomized 1:1 controlled trial to prove the clinical and medico economic benefits of the medical device Predigraft, by showing that the use of Predigraft could improve patient's follow-up.

  • 0 views
  • 07 Oct, 2022
  • 8 locations
Antithymocyte Globulin and Azathioprine Versus Basiliximab and Mycophenolate Mofetil in Living Donor Kidney Transplantation

Kidney transplantation is the best available treatment option for patients with end stage renal disease. However, kidney transplantation requires life-long use of immunosuppressive medication. Because of the high cost of these medications we need to carefully evaluate the cost-effectiveness of each drug regimen, especially in low-middle income countries. The objective …

  • 2 views
  • 22 Jan, 2021
  • 1 location
Mesenchymal Stromal Cells in Kidney Transplant Recipients

The general aim of the present study is to test a cell therapy with autologous ex-vivo expanded mesenchymal stromal cells (MSCs) as a strategy to induce tolerance in living-donor kidney transplant recipients. MSCs will be prepared accordingly to established protocols, starting from bone marrow explants of living-donor kidney transplant recipients …

kidney transplant
cell therapy
  • 15 views
  • 03 Dec, 2021
  • 1 location
Added Value of 18 FDG Pet-scanner in Diagnosis and Management of Subclinical Rejection in Kidney Transplant Patients

The renal biopsy (RB) represents the gold-standard for the diagnosis of acute renal transplant rejection (AR), and allows early verification of a so-called "subclinical" rejection, ie without

  • 0 views
  • 25 Mar, 2022
  • 1 location
Efficacy of Achieving Early Target Trough Levels of Tacrolimus Using CYP3A5 Guided Dosing Versus Weight-based Dosing in a Multi-ethnic Population of Kidney Transplant Recipients in Singapore

The investigators hypothesise that the adaptation of CYP3A5 genotype-based Tacrolimus (FK) dosing will lead to earlier FK target achievement and consequently, better clinical outcome after kidney transplantation (RTx). This study aims to shed light on the possible impact of CYP3A genotype-based FK dosing on FK target achievement and clinical outcome …

  • 0 views
  • 26 Dec, 2021
  • 1 location
Desensitization in Kidney Allograft Using Daratumumab

Patients highly allosensitized against HLA antigen awaiting for a kidney transplant have less compatible transplants to them, increasing their waitlist time and mortality. Current desensitization strategies need to be improved with a high remaining acute rejection rate in this population and a substantial survival benefit which is not uniformly reported …

daratumumab
kidney transplant
monoclonal antibodies
immunoglobulin
  • 0 views
  • 24 Jan, 2021
  • 1 location
Urine CXCL10 Monitoring Trial in Kidney Transplant

This is a Phase II-III multi-center prospective randomized controlled clinical trial of incident adult renal transplant patients. The primary objective of this study is to determine if the early treatment of rejection, as detected by urinary CXCL10, will improve renal allograft outcomes.

cxcl10
kidney transplant
  • 29 views
  • 03 Jun, 2022
  • 7 locations
Immunosuppression Management in Renal Transplant Recipients With Transplant Excellence Based on TruGraf Test

This is an investigator-initiated, single-center, prospective, randomized, proof of concept study. In this study patients who are status post kidney transplantation and meet the inclusion and exclusion criteria will undergo immunosuppression reduction and will be followed closely to assess stability of graft function.

  • 0 views
  • 03 Sep, 2021
  • 1 location
Protocol Biopsies in High-risk Renal Transplant Recipients

The present study aims to evaluate the usefulness of protocol biopsies in a cohort of renal transplant patients of high immunological risk for graft injury and loss.

kidney transplant
antibody-mediated rejection
flow cytometry
percutaneous renal biopsy
kidney biopsy
  • 0 views
  • 26 Feb, 2022
  • 1 location