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Found 14 clinical trials
A Randomized Controlled Trial Comparing Imipenem and Tigecycline Versus Imipenem and Tigecycline With GM-CSF for the Management of Spontaneous Bacterial Peritonitis Presenting With Septic Shock.

> Haemoglobin, Total peripheral leucocyte counts, Platelet counts, Renal function tests Liver function tests and Chest X rays will be undertaken

  • 0 views
  • 24 Jan, 2021
  • 1 location
Impact of Amantadine on Traumatic Brain Injury

The aim of this study is to evaluate whether the addition of amantadine to the management regimen of traumatic brain injury patients would have a favorable effect on recovery and neurological complications in association with prognosis biomarkers Interleukin-18 (IL-18), Neuron-specific enolase (NSE) and (Neurotensin).

  • 0 views
  • 17 Jan, 2021
  • 1 location
Protective Role of Vitamin D in Breast Cancer Patients Treated With Doxorubicin

The study is aimed at Evaluation of the potential protective effect of Vitamin D in doxorubucin- induced toxicity in breast cancer patients. Proposal Steps: 100 Patients recruited from Alexandria Main University Hospital (AMUH), Oncology Unit are randomly assigned in to two groups: Control group (n=50) the patient will receive AC …

doxorubicin
cyclophosphamide
  • 0 views
  • 25 Jan, 2021
  • 1 location
Mesenchymal Stem Cells Transplantation for Refractory Systemic Lupus Erythematosus (SLE)

This study will explore a new approach to treat patients with a medical condition known as systemic lupus erythematosus (SLE) who have been resistant to previous treatments using a new population of cells with capability to restore a normal immune system that will no longer attack the body. The stated …

  • 30 views
  • 07 Nov, 2020
  • 1 location
Pharmacokinetics of Ledipasvir/Sofosbuvir in Hepatitis C Virus-Infected Children With Hematological Malignancy

This is a prospective, controlled, open-label, pharmacokinetic study. This study aims at studying the PK of ledipasvir, sofosbuvir, and GS-331007 metabolite in HCV infected children with hematological malignancy. In this study, patients in both treatment groups will receive 12 weeks of treatment with a xed-dose combination tablet containing 45 mg …

  • 0 views
  • 22 Jan, 2021
  • 1 location
Safety and Efficacy of High Dose Rifampicin in Tuberculosis (TB)-HIV Co-infected Patients on Efavirenz- or Dolutegravir-based Antiretroviral Therapy

Higher doses of rifampicin has been associated with a faster drop in bacterial load over time, and shorter treatment regimens with high dose rifampicin are being proposed. Sub-therapeutic rifampicin concentrations are common in TB patients and have been demonstrated in several studies carried out among patients with tuberculosis receiving the …

hepatotoxicity
combinations
efavirenz
HIV Infection
rifampin
  • 4 views
  • 23 Jan, 2021
  • 1 location
Efficacy and Safety of Dabigatran in Patients With Cirrhosis and Portal Vein Thrombosis

A randomized controlled trial to study the efficacy and safety of Dabigatran in Cirrhotic patients who develop PVT.In this study the patients who meet the inclusion criteria will be randomized to either receive Dabigatran or placebo [multivitamin tablet]. Blood samples will be taken &Imaging will be done accordingly to notice …

portal vein thrombosis
cirrhosis
  • 20 views
  • 25 Jan, 2021
  • 1 location
Incretin and Treatment With Inhibition of Sodium-glucose Cotransporter-2 Combination Insights Into Mechanisms Implicated in Congestive Heart Failure: "NATRIURETIC" Trial

This study aims to provide essential mechanistic insights into natriuretic and hemodynamic effects of SGLT2i and GLP-1RA agents in T2D patients. Ultimately, by obtaining physiological data in T2D patients without HF, our aims are to gain insight into how the use of this combined therapy may be used in T2D …

body mass index
ace inhibitor
liraglutide
  • 0 views
  • 25 Jan, 2021
  • 1 location
Perioperative Therapy Preoperative Chemotherapy Versus Chemoradiotherapy in Locally Advanced Gall Bladder Cancers

Locally advanced Gall bladders cancers not amenable for curative resection are often treated with chemotherapy alone which is the current standard of care. Randomized trials have shown survival benefit with combination chemotherapy in gallbladder cancers. Gallbladder cancer is not common western world and thus there is lack of evidence regarding …

metastasis
jaundice
combination chemotherapy
gemcitabine
serum bilirubin
  • 38 views
  • 22 Jan, 2021
  • 1 location
Suvorexant in the Management Comorbid Sleep Disorder and Alcohol Dependence

Suvorexant (trade name Belsomra) is an orexin receptor antagonist that has TGA approval for the treatment of insomnia, characterised by difficulties with sleep onset and/or sleep maintenance. It may also have a role in addictions as the orexins play a critical role in drug addiction and reward-related behaviours. Orexins appear …

  • 0 views
  • 23 Jan, 2021
  • 1 location