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Found 56 clinical trials
Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial

This phase Ib trial determines if samples from a patient's cancer can be tested to find combinations of drugs that provide clinical benefit for the kind of cancer the patient has. This study is also being done to understand why cancer drugs can stop working and how different cancers in …

tretinoin
palbociclib
abemaciclib
glomerular filtration rate
myelofibrosis
  • 2 views
  • 04 Oct, 2022
  • 1 location
A Phase 1/1b Study Evaluating the Safety, Pharmacokinetics, and Preliminary Efficacy of LP-118 in Subjects With Relapsed or Refractory Hematological Malignancies

This is a Phase 1, multi-center, open-label study with a dose-escalation phase (Phase 1a) and a cohort expansion phase (Phase 1b), to evaluate the safety, tolerability, and PK profile of LP-118 under a once daily oral dosing schedule in up to 100 subjects.

tyrosine
combination chemotherapy
bone marrow procedure
multiple myeloma
blast cells
  • 2 views
  • 25 Oct, 2022
  • 5 locations
Allogeneic T Cells Immunotherapy in r/r Non-Hodgkin's Lymphoma (NHL) or Peripheral T Cell Lymphomas (PTCL) Patients

This study aims to evaluate the safety, tolerability and efficacy of ex-vivo expanded allogeneic T cells obtained from a blood-related donor of patients with relapsed or refractory B cell non-Hodgkin's lymphoma (B-NHL) or peripheral T cell lymphoma (PTCL) expect for T lymphoma.

  • 0 views
  • 27 Jan, 2021
  • 1 location
Autologous Hematopoietic Stem Cell Transplantation Combined With CAR-T Cells in the Treatment of Refractory and Relapsed Malignant Lymphoma

Clinical Study on the Safety and Effectiveness of Autologous Hematopoietic Stem Cell Transplantation Combined With CAR-T Cells in the Treatment of Refractory and Relapsed Malignant Lymphoma

chronic lymphocytic leukemia
b-cell lymphoma
remission
leukemia
filgrastim
  • 0 views
  • 24 Mar, 2022
  • 1 location
Study of Kappa Chimeric Antigen Receptor (CAR) T Lymphocytes Co-Expressing the Kappa and CD28 CARs for Relapsed/Refractory Kappa+ Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma.

This study will combine both T cells and antibodies in order to create a more effective treatment. The treatment tested in this study uses modified T-cells called Autologous T Lymphocyte Chimeric Antigen Receptor (ATLCAR) cells targeted against the kappa light chain antibody on cancer cells. For this study, the anti-kappa …

lymphoma cells
fludarabine
mantle cell lymphoma
leukemia
refractory follicular lymphoma
  • 15 views
  • 09 Dec, 2021
  • 1 location
A Study of ASCT Bridging CART Cell Therapy in Relapsed/Refractory B-cell Lymphoma

This is a single center, prospective cohort study to to evaluate the efficacy and safety of autologous hematopoietic stem cell transplantation(ASCT) bridging chimeric antigen receptor T (CART) cell therapy in the treatment of relapsed/refractory B-cell non-Hodgkin's lymphoma.

  • 0 views
  • 16 Jun, 2021
  • 1 location