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Found 32 clinical trials
Brentuximab Vedotin With or Without Nivolumab in Treating Patients With Relapsed or Refractory CD30+ Lymphoma

This phase II pilot trial studies how well brentuximab vedotin with or without nivolumab works in treating patients with CD30+ lymphoma that has come back after a period of improvement or does not respond to treatment. Biological therapies, such as brentuximab vedotin, may stimulate the immune system in different ways …

biological therapies
neutrophil count
monoclonal antibodies
measurable disease
tumor cells
  • 2 views
  • 19 Jun, 2021
  • 1 location
Nivolumab Ifosfamide Carboplatin and Etoposide as Second-Line Therapy in Treating Patients With Refractory or Relapsed HL

This phase II trial studies the side effects of nivolumab and to see how well it works when given together with ifosfamide, carboplatin, and etoposide in treating patients with Hodgkin lymphoma that has come back (relapsed) and does not respond to treatment (refractory). Immunotherapy with monoclonal antibodies such as nivolumab, …

  • 1 views
  • 03 Jul, 2021
  • 4 locations
Gemcitabine Hydrochloride Clofarabine and Busulfan Before Donor Stem Cell Transplant in Treating Patients With Refractory B-Cell or T-Cell Non-Hodgkin Lymphoma or Hodgkin Lymphoma

This phase I/II trial studies the side effects and best dose of gemcitabine hydrochloride, clofarabine, and busulfan before donor stem cell transplant and to see how well it works in treating patients with B-cell or T-cell non-Hodgkin lymphoma or Hodgkin lymphoma that does not respond to treatment. Giving chemotherapy before …

ejection fraction
rituximab
peripheral blood stem cell transplantation
antithymocyte globulin
cell transplantation
  • 11 views
  • 29 Jan, 2021
  • 1 location
Olaparib and High-Dose Chemotherapy in Treating Patients With Relapsed or Refractory Lymphomas Undergoing Stem Cell Transplant

This phase I trial studies the side effects and best dose of olaparib when given together with high-dose chemotherapy in treating patients with lymphomas that have come back or does not treatment and are undergoing stem cell transplant. Drugs used in chemotherapy, such as olaparib, vorinostat, gemcitabine, busulfan, and melphalan, …

ejection fraction
gilbert's syndrome
rituximab
cell transplantation
salvage therapy
  • 2 views
  • 25 Jan, 2021
  • 1 location
Flotetuzumab for the Treatment of Relapsed or Refractory Advanced CD123-Positive Hematological Malignancies

This phase I trial studies the best dose and side effects of flotetuzumab for the treatment of patients with blood cancers (hematological malignancies) that have spread to other places in the body (advanced) and have come back after a period of improvement (relapsed) or does not respond to treatment (refractory). …

  • 0 views
  • 04 Feb, 2021
  • 1 location
Pembrolizumab in Treating Patients With HIV and Relapsed Refractory or Disseminated Malignant Neoplasms

This phase I trial studies the side effects of pembrolizumab in treating patients with human immunodeficiency virus (HIV) and malignant neoplasms that have come back (relapsed), do not respond to treatment (refractory), or have distributed over a large area in the body (disseminated). Immunotherapy with monoclonal antibodies, such as pembrolizumab, …

measurable disease
lung cancer
solid neoplasm
immune globulin
cancer
  • 142 views
  • 19 Jul, 2021
  • 5 locations
Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial

This phase Ib trial determines if samples from a patient's cancer can be tested to find combinations of drugs that provide clinical benefit for the kind of cancer the patient has. This study is also being done to understand why cancer drugs can stop working and how different cancers in …

oxaliplatin
myeloproliferative disorders
idelalisib
absolute neutrophil count
hodgkin's disease
  • 0 views
  • 26 Jul, 2021
  • 1 location
Study of CD30 CAR for Relapsed/Refractory CD30+ HL and CD30+ NHL

The body has different ways of fighting infection and disease. No single way seems perfect for fighting cancer. This research study combines two different ways of fighting disease: antibodies and T cells. Antibodies are proteins that protect the body from disease caused by bacteria or toxic substances. Antibodies work by …

neutrophil count
gilbert's syndrome
bacterial infection
primary cancer
stem cell transplantation
  • 88 views
  • 17 Jul, 2021
  • 1 location
Brentuximab Vedotin as Alternative to the Autologous Stem Cell Transplantation in Relapsed and Refractory Classical Hodgkin's Lymphoma (BASALT)

This study evaluate possibility of brentuximab vedotin, administered after first treatment failure (no response or relapse after I line therapy) of Hodgkin's lymphoma, to induce durable response or cure without autologous stem cell transplantation.

lymphoma
measurable disease
chemotherapy regimen
brentuximab
platelet count
  • 3 views
  • 25 Jan, 2021
  • 3 locations
Nivolumab and Lenalidomide in Treating Patients With Relapsed or Refractory Non-Hodgkin or Hodgkin Lymphoma

This I/II trial studies the side effects and best dose of lenalidomide when given together with nivolumab and to see how well they work in treating patients with non-Hodgkin or Hodgkin lymphoma that has come back and does not respond to treatment. Monoclonal antibodies, such as nivolumab, may interfere with …

neutrophil count
absolute neutrophil count
gilbert's syndrome
hodgkin's disease
burkitt's lymphoma
  • 121 views
  • 22 May, 2021
  • 2 locations