Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 21 clinical trials
None
A Study to Compare the Efficacy and Safety of Ifosfamide and Etoposide With or Without Lenvatinib in Children Adolescents and Young Adults With Relapsed and Refractory Osteosarcoma

Etoposide in Children, Adolescents, and Young Adults with Relapsed or Refractory Osteosarcoma.

ifosfamide
refractory osteosarcoma
etoposide
cancer chemotherapy
cancer
  • 50 views
  • 01 Dec, 2021
  • 83 locations
None
Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors Non-Hodgkin Lymphomas or Histiocytic Disorders (The Pediatric MATCH Screening Trial)

This Pediatric MATCH screening and multi-sub-study phase II trial studies how well treatment that is directed by genetic testing works in pediatric patients with solid tumors, non-Hodgkin lymphomas, or histiocytic disorders that have progressed following at least one line of standard systemic therapy and/or for which no standard treatment exists …

myelosuppressive chemotherapy
brain stem tumor
lymphoma
chemotherapeutic agents
tazemetostat
  • 997 views
  • 26 Nov, 2021
  • 114 locations
None
Gemcitabine Docetaxel and Hydroxychloroquine in Treating Participants With Recurrent or Refractory Osteosarcoma

This phase I/II trial studies the side effects and best dose of hydroxychloroquine and how well it works when given together with gemcitabine and docetaxel in treating participants with osteosarcoma that has come back or does not respond to treatment. Drugs used in chemotherapy, such as gemcitabine, docetaxel, and hydroxychloroquine, …

glomerular filtration rate
tumor cells
platelet count
neutrophil count
refractory osteosarcoma
  • 1 views
  • 23 Jan, 2021
  • 1 location
None
Apatinib Plus IE Chemotherapy (Ifosfamide and Etoposide) for Relapsed or Refractory Osteosarcoma

compared the activity of apatinib + IE in relapsed or refractory osteosarcoma in two sarcoma centers in China and concluded that for osteosarcoma with multiple sites of metastasis, apatinib + IE

  • 0 views
  • 21 Jul, 2021
  • 2 locations
None
Study of CAR T-Cells Targeting the GD2 With IL-15+iCaspase9 for Relapsed/Refractory Neuroblastoma or Relapsed/Refractory Osteosarcoma

The body has different ways of fighting infections and disease. No single way seems perfect for fighting cancer. This research study combines two different ways of fighting disease: antibodies and T cells. Antibodies are molecules that fight infections and protect your body from diseases caused by bacteria and toxic substances. …

refractory neuroblastoma
cyclophosphamide
shortening fraction
measurable disease
gm-csf
  • 16 views
  • 18 Jul, 2021
  • 1 location
None
Testing a New Immune Cell Therapy GD2-Targeted Modified T-cells (GD2CART) in Children Adolescents and Young Adults With Relapsed/Refractory Osteosarcoma and Neuroblastoma The GD2-CAR PERSIST Trial

This phase I trial investigates the side effects and determines the best dose of an immune cell therapy called GD2CART, as well as how well it works in treating patients with osteosarcoma or neuroblastoma that has come back (relapsed) or does not respond to treatment (refractory). T cells are infection …

  • 0 views
  • 24 Oct, 2021
  • 1 location
None
A Study of ZN-c3 in Combination With Gemcitabine in Subjects With Osteosarcoma

This is a phase 1/2 study of ZN-c3 in combination with gemcitabine in adult and pediatric subjects with relapsed or refractory osteosarcoma.

gemcitabine
refractory osteosarcoma
measurable disease
metastatic osteosarcoma
  • 0 views
  • 26 Nov, 2021
  • 8 locations
None
Cabozantinib With Topotecan-Cyclophosphamide

This research study is a clinical trial of a new combination of drugs as a possible treatment for relapsed/refractory Ewing sarcoma and/or osteosarcoma. The names of the drugs are: Cabozantinib Topotecan Cyclophosphamide The names of the non-investigational supportive care drugs are: Filgrastim, pegfilgrastim, or a related growth factor.

  • 0 views
  • 07 Oct, 2021
  • 2 locations
None
Nab-Paclitaxel and Gemcitabine for Recurrent/Refractory Sarcoma

The purpose of this study is to see if nab-paclitaxel combined with gemcitabine prevents the formation or growth of tumors in participants with relapsed or refractory osteosarcoma, Ewing sarcoma

ct scan
myelosuppressive chemotherapy
measurable disease
soft tissue sarcoma
pegfilgrastim
  • 146 views
  • 12 Sep, 2021
  • 16 locations
None
Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma

The phase I portion of this study is designed for children or adolescents and young adults (AYA) with a diagnosis of a solid tumor that has recurred (come back after treatment) or is refractory (never completely went away). The trial will test 2 combinations of therapy and participants will be …

  • 0 views
  • 18 Oct, 2021
  • 8 locations