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Found 15 clinical trials
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TK216 in Patients With Relapsed or Refractory Ewing Sarcoma

Ewing sarcoma is characterized by genomic rearrangements resulting in over-expression of ets family transcription factors driving tumor progression. TK216 is designed to inhibit this effect by inhibiting downstream effects of the EWS-FLI1 transcription factor. This study is a first in human study of TK216 in subjects with Ewing sarcoma. The …

refractory ewing sarcoma
vincristine
  • 2 views
  • 03 Dec, 2021
  • 9 locations
None
Safety and Efficacy Study of Pembrolizumab (MK-3475) in Combination With Investigational Agents for the Treatment of Extensive-Stage Small Cell Lung Cancer (ES-SCLC) in Need of Second-Line Therapy (MK-3475-B98/KEYNOTE-B98)

) refractory ES-SCLC in need of second-line treatment. This study will have 2 parts: an initial safety lead-in to determine safety and tolerability for experimental combinations of investigational agents

measurable disease
pembrolizumab
  • 0 views
  • 08 Dec, 2021
  • 27 locations
None
Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors Non-Hodgkin Lymphomas or Histiocytic Disorders (The Pediatric MATCH Screening Trial)

This Pediatric MATCH screening and multi-sub-study phase II trial studies how well treatment that is directed by genetic testing works in pediatric patients with solid tumors, non-Hodgkin lymphomas, or histiocytic disorders that have progressed following at least one line of standard systemic therapy and/or for which no standard treatment exists …

neutrophil count
cytotoxic chemotherapy
blood count
cns tumors
tumor markers
  • 1013 views
  • 26 Nov, 2021
  • 114 locations
None
Cabozantinib With Topotecan-Cyclophosphamide

This research study is a clinical trial of a new combination of drugs as a possible treatment for relapsed/refractory Ewing sarcoma and/or osteosarcoma. The names of the drugs are

  • 0 views
  • 07 Oct, 2021
  • 2 locations
None
Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors

, adolescents, and young adults with recurrent or refractory Ewing sarcoma (EWS). Pharmacokinetics and efficacy of palbociclib in combination with chemotherapy will be evaluated.

renal function test
rhabdoid tumor
renal function
solid tumour
neutrophil count
  • 128 views
  • 03 Dec, 2021
  • 67 locations
None
Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma

The phase I portion of this study is designed for children or adolescents and young adults (AYA) with a diagnosis of a solid tumor that has recurred (come back after treatment) or is refractory (never completely went away). The trial will test 2 combinations of therapy and participants will be …

  • 0 views
  • 18 Oct, 2021
  • 8 locations
None
Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors Including Lymphomas and Desmoid Tumors

This phase I/II trial evaluates the highest safe dose, side effects, and possible benefits of tegavivint in treating patients with solid tumors that has come back (recurrent) or does not respond to treatment (refractory). Tegavivint interferes with the binding of beta-catenin to TBL1, which may help stop the growth of …

  • 0 views
  • 08 Dec, 2021
  • 5 locations
None
Palbociclib in Treating Patients With Relapsed or Refractory Rb Positive Advanced Solid Tumors Non-Hodgkin Lymphoma or Histiocytic Disorders With Activating Alterations in Cell Cycle Genes (A Pediatric MATCH Treatment Trial)

This phase II Pediatric MATCH trial studies how well palbociclib works in treating patients with Rb positive solid tumors, non-Hodgkin lymphoma, or histiocytic disorders with activating alterations (mutations) in cell cycle genes that have spread to other places in the body and have come back or do not respond to …

antineoplastic
glomerular filtration rate
neutrophil count
solid tumor
autologous stem cell infusion
  • 187 views
  • 02 Dec, 2021
  • 82 locations
None
Ivosidenib in Treating Patients With Advanced Solid Tumors Lymphoma or Histiocytic Disorders With IDH1 Mutations (A Pediatric MATCH Treatment Trial)

This phase II Pediatric MATCH trial studies how well ivosidenib works in treating patients with solid tumors that have spread to other places in the body (advanced), lymphoma, or histiocytic disorders that have IDH1 genetic alterations (mutations). Ivosidenib may block the growth of cancer cells that have specific genetic changes …

antineoplastic
glomerular filtration rate
nervous system disorders
neutrophil count
solid tumor
  • 389 views
  • 02 Dec, 2021
  • 90 locations
None
Selpercatinib for the Treatment of Advanced Solid Tumors Lymphomas or Histiocytic Disorders With Activating RET Gene Alterations a Pediatric MATCH Treatment Trial

This phase II pediatric MATCH trial studies how well selpercatinib works in treating patients with solid tumors that have spread to other places in the body (advanced), lymphomas, or histiocytic disorders that have activating RET gene alterations. Selpercatinib may block the growth of cancer cells that have specific genetic changes …

antineoplastic
glomerular filtration rate
neutrophil count
solid tumor
autologous stem cell infusion
  • 18 views
  • 03 Dec, 2021
  • 90 locations