Found 15 clinical trials
Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease
Background: Peripheral blood stem cell transplantation procedures are used for people with sickle cell disease. Researchers want to improve the success and reduce the complications for these procedures. This might allow more people to have a transplant. Objective: To see if a new transplant regime is effective, safe and well …
- 83 views
- 22 Dec, 2020
- 1 location
Genotype -Phenotype Correlation of PKLR Variants with Pyruvate Kinase, 2,3-Diphosphglycerate and ATP Activities in Red Blood Cells of Patients with Sickle Cell Disease
Background: Some people with the same disorder on a genetic level have more complications than others. Researchers want to look for a link between the PKLR gene and sickle cell disease (SCD) symptoms. The PKLR gene helps create a protein, called pyruvate kinase that is essential in normal functioning of …
- 63 views
- 22 Dec, 2020
- 1 location

COMMANDS - Myelodysplastic Syndromes (MDS) - ACE536-MDS-002 - US
The study will be conducted in compliance with the International Council for Harmonisation (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use/Good Clinical Practice (GCP) and applicable regulatory requirements. This is an interventional active-controlled, open-label, randomized Phase 3 study to compare the efficacy and safety of luspatercept …
- 54541 views
- 22 Aug, 2022
- 9 locations

COMMANDS - Myelodysplastic Syndromes (MDS) - ACE536-MDS-002 – Canada
The study will be conducted in compliance with the International Council for Harmonisation (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use/Good Clinical Practice (GCP) and applicable regulatory requirements. This is an interventional active-controlled, open-label, randomized Phase 3 study to compare the efficacy and safety of luspatercept …
- 23120 views
- 22 Aug, 2022
- 10 locations

COMMANDS - Myelodysplastic Syndromes (MDS) - ACE536-MDS-002 - Australia
The study will be conducted in compliance with the International Council for Harmonisation (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use/Good Clinical Practice (GCP) and applicable regulatory requirements. This is an interventional active-controlled, open-label, randomized Phase 3 study to compare the efficacy and safety of luspatercept (ACE-536) …
- 16800 views
- 22 Aug, 2022
- 7 locations
Association Between Dapagliflozin-induced Improvement and Anemia in Heart Failure Patients (ADIDAS)
The primary objective of this study is to investigate the hemoglobin change and association between hemoglobin change and readmissions due to heart failure, and all-cause death in patients with heart failure treated with dapagliflozin or placebo.
- 0 views
- 05 Nov, 2021
- 1 location
Nonmyeloablative Stem Cell Transplant in Children With Sickle Cell Disease and a Major ABO-Incompatible Matched Sibling Donor (Sickle-AID)
The aim of this study to evaluate the safety and efficacy of a nonmyeloablative conditioning regimen for allogeneic hematopoietic stem cell transplantation (HSCT) in pediatric patients with sickle cell disease (SCD) who have a matched related major ABO-incompatible donor. The nonmyeloablative regimen will use alemtuzumab, total body irradiation (TBI) and …
- 9 views
- 26 Jan, 2022
- 1 location
Topical Sodium Nitrite in Sickle Cell Disease and Leg Ulcers
The investigators propose a Phase II study, prospective and placebo controlled, of a topical cream containing sodium nitrite compared to the current standard of care. Sodium nitrite is a local donor of nitric oxide, which is known to improve blood flow and decrease bacterial load in the ulcer bed. The …
- 33 views
- 26 Apr, 2022
- 2 locations
Clinical Study the Efficacy and Safety of Rh-EPO in the Treatment of Anemia in Lymphoma
The incidence of lymphoma and anemia is high and the clinical harm is great.However, it has not yet attracted enough clinical attention, and domestic rHuEPO (trade name: Ebio).Shenyang Sansheng Pharmaceutical Co., Ltd.) for lymphoma and anemia patients are less clinical studies.Therefore, a prospective, open-label, multicenter clinical study of recombinant human …
- 0 views
- 21 Aug, 2021
- 1 location
Ferric Carboxymaltose With or Without Phosphate Substitution for the Treatment of Iron Deficiency or Iron Deficiency Anemia
This is a confirmatory trial to establish superior serum phosphate stability associated with use of Phoscap compared with placebo as a supplement for treatment of iron deficiency or iron deficiency anemia with Ferinject before elective surgery.
- 0 views
- 29 Nov, 2021
- 1 location
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