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Found 77 clinical trials
Bintrafusp Alfa in Previously Treated Patients With Recurrent and Metastatic (R/M) Non-keratinizing Nasopharyngeal Carcinoma (NPC)

This would be a phase II prospective single arm mono-institutional study conducted in Queen Mary Hospital (Hong Kong) assessing the efficacy and safety of bintrafusp alfa in previously treated patients with recurrent and metastatic (R/M) non-keratinizing nasopharyngeal carcinoma (NPC).

serum total bilirubin
chemotherapy regimen
nasopharyngeal carcinoma
platelet count
combination therapy
  • 8 views
  • 25 Jan, 2021
  • 1 location
A Study to Investigate LYL797 in Adults With Solid Tumors

This study will evaluate the safety and tolerability of LYL797, a ROR1-targeted CAR T-cell therapy, in patients with ROR1+ relapsed or refractory triple negative breast cancer (TNBC) or non-small cell lung cancer (NSCLC). The first part of the study will determine the safe dose for the next part of the …

measurable disease
immunohistochemistry
triple negative breast cancer
lung carcinoma
  • 0 views
  • 08 Apr, 2022
A Clinical Study of CEA-targeted CAR-T in the Treatment of CEA-positive Advanced Malignant Solid Tumors

This is a phase I clinical study to evaluate the safety and tolerability of CAR-T in patients with CEA-positive advanced malignant solid tumors, and to obtain the maximum tolerated dose of CAR-T and phase II Recommended dose.

renal function
esophagus cancer
pancreatic cancers
cancer
cancer chemotherapy
  • 0 views
  • 17 Jun, 2022
  • 1 location
A Clinical Study of CEA-targeted CAR-T in the Treatment of CEA-positive Advanced Malignant Solid Tumors

This is a phase I clinical study to evaluate the safety and tolerability of CAR-T in patients with CEA-positive advanced malignant solid tumors, and to obtain the maximum tolerated dose of CAR-T and phase II Recommended dose.

  • 0 views
  • 30 Jun, 2022
A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma

in the tumor and blood when given prior to and during a planned surgery for removal of the recurrent tumor. The goals of the first part: Find the highest safe dose of PTC596

renal function
platelet count
glioblastoma multiforme
diffuse intrinsic pontine glioma
total resection
  • 1 views
  • 24 Mar, 2022
  • 9 locations
TCR-engineered T Cells in Solid Tumors: IMA202-101 (ACTengine)

The study purpose is to establish the safety and tolerability of IMA202 product in patients with solid tumors that express melanoma-associated antigen 1 (MAGEA1).

renal function
cirrhosis
primary cancer
hepatocellular carcinoma
carcinoma
  • 68 views
  • 26 Feb, 2022
  • 6 locations
  • 0 views
  • 26 Jan, 2021
  • 1 location
Chemoradiation vs Immunotherapy and Radiation for Head and Neck Cancer

The purpose of this study is to compare any good or bad effects of using pembrolizumab (an experimental drug) and radiation therapy (RT), compared to using cisplatin chemotherapy and radiation therapy (RT) in the treatment of patients with head and neck squamous cell carcinoma (HNSCC).

pembrolizumab
primary cancer
chemoradiotherapy
carcinoma
squamous cell carcinoma
  • 0 views
  • 04 Mar, 2022
  • 7 locations
Donor Natural Killer Cells, Cyclophosphamide, and Etoposide in Treating Children and Young Adults With Relapsed or Refractory Solid Tumors

This phase I trial studies the side effects and best dose of cord blood-derived expanded allogeneic natural killer cells (donor natural killer [NK] cells) and how well they work when given together with cyclophosphamide and etoposide in treating children and young adults with solid tumors that have come back (relapsed) …

alopecia
white blood cell count
gilbert's syndrome
pulse oximetry
cancer
  • 20 views
  • 14 Feb, 2022
  • 1 location
Testing the Addition of an Experimental Medication MK-3475 (Pembrolizumab) to Usual Anti-Retroviral Medications in Patients With HIV and Cancer

This phase I trial studies the side effects of pembrolizumab in treating patients with human immunodeficiency virus (HIV) and malignant neoplasms that have come back (relapsed), do not respond to treatment (refractory), or have distributed over a large area in the body (disseminated). Immunotherapy with monoclonal antibodies, such as pembrolizumab, …

solid tumors
b-cell lymphoma
pembrolizumab
HIV Infection
lung cancer
  • 142 views
  • 19 Jun, 2022
  • 6 locations