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Found 71 clinical trials
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Ensartinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors Non-Hodgkin Lymphoma or Histiocytic Disorders With ALK or ROS1 Genomic Alterations (A Pediatric MATCH Treatment Trial)

This phase II Pediatric MATCH trial studies how well ensartinib works in treating patients with solid tumors, non-Hodgkin lymphoma, or histiocytic disorders with ALK or ROS1 genomic alterations that have come back (recurrent) or do not respond to treatment (refractory) and have spread to other places in the body (advanced). …

131i-mibg
myelosuppressive chemotherapy
hematopoietic growth factors
growth factor
stem cell transplantation
  • 68 views
  • 02 Dec, 2021
  • 78 locations
None
Samotolisib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors Non-Hodgkin Lymphoma or Histiocytic Disorders With TSC or PI3K/MTOR Mutations (A Pediatric MATCH Treatment Trial)

This phase II Pediatric MATCH trial studies how well samotolisib works in treating patients with solid tumors, non-Hodgkin lymphoma, or histiocytic disorders with TSC or PI3K/MTOR mutations that have spread to other places in the body (metastatic) and have come back (recurrent) or do not respond to treatment (refractory). Samotolisib …

cns neoplasm
myelosuppressive chemotherapy
hematopoietic growth factors
growth factor
pleural effusion
  • 377 views
  • 02 Dec, 2021
  • 86 locations
None
Study of Binimetinib With Encorafenib in Adults With Recurrent BRAF V600-Mutated HGG

The goal of this study is to estimate the efficacy of encorafenib and binimetinib as measured by radiographic response in recurrent high-grade primary brain tumors.

primary brain neoplasm
binimetinib
cancer
cytotoxic chemotherapy
serum pregnancy test
  • 32 views
  • 19 Sep, 2021
  • 9 locations
None
18F-Fluciclovine PET and Multiparametric MR Imaging

The purpose of the study is to investigate the use of the investigational agent Axumin (fluciclovine-F18) with PET/CT imaging in combination with standard MR imaging to detect remaining or recurrent brain tumor.

  • 0 views
  • 01 Oct, 2021
  • 1 location
None
A Study of Intravenous EEDVsMit in Children With Recurrent / Refractory Solid or CNS Tumours Expressing EGFR

This is an open-label, sequential dose exploration study of single agent EEDVSMit administered by intravenous (IV) infusion twice weekly, followed by weekly maintenance dosing, in children with recurrent/refractory solid or CNS tumours.

  • 0 views
  • 25 Jan, 2021
  • 2 locations
None
Dose Escalation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma

Background A glioblastoma is a tumor in the brain. It is treated with surgery, chemotherapy and radiation therapy. However, most people s tumors come back after therapy. When the tumor grows back, surgery or chemotherapy may not be possible or may no longer work. Repeat radiation therapy or re-irradiation, is …

temozolomide
combined modality therapy
glioblastoma multiforme
cytotoxic chemotherapy
recurrent glioblastoma
  • 41 views
  • 09 Nov, 2021
  • 1 location
None
Trial of C134 in Patients With Recurrent GBM

The purpose of this project is to obtain safety information in small groups of individuals, scheduled to receive escalating doses of C134, a cancer killing virus (HSV-1) that has been genetically engineered to safely replicate and kill glioma tumor cells. Safety will be assessed at each dose level before proceeding …

  • 14 views
  • 13 Jun, 2021
  • 1 location
None
SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors

Approximately 90% of children with malignant brain tumors that have recurred or relapsed after receiving conventional therapy will die of disease. Despite this terrible and frustrating outcome, continued treatment of this population remains fundamental to improving cure rates. Studying this relapsed population will help unearth clues to why conventional therapy …

ribociclib
recurrent brain tumors
combined modality therapy
trametinib
cancer
  • 211 views
  • 01 Sep, 2021
  • 1 location
None
Prediction of Therapeutic Response of Apatinib in Recurrent Gliomas

recurrent gliomas whose are treated with Apatinib, for evaluating the efficacy and safety of Apatinib. Moreover, by leveraging artificial intelligence, this study seeks to construct and refine MR and

  • 0 views
  • 18 Feb, 2021
  • 1 location
None
A Biospecimen Collection Study in BRAF-V600E Mutated Recurrent Gliomas

This is a surgical biospecimen collection study. The purpose of this study is to understand how much of two drugs (dabrafenib and trametinib) are able to penetrate brain tumors and turn off the RAF signaling pathway. This is important because these drugs are currently FDA approved for other tumors and …

dabrafenib
BRAF
trametinib
ganglioglioma
primary brain tumors
  • 28 views
  • 16 Sep, 2021
  • 6 locations