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Found 71 clinical trials
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Palbociclib in Treating Patients With Relapsed or Refractory Rb Positive Advanced Solid Tumors Non-Hodgkin Lymphoma or Histiocytic Disorders With Activating Alterations in Cell Cycle Genes (A Pediatric MATCH Treatment Trial)

This phase II Pediatric MATCH trial studies how well palbociclib works in treating patients with Rb positive solid tumors, non-Hodgkin lymphoma, or histiocytic disorders with activating alterations (mutations) in cell cycle genes that have spread to other places in the body and have come back or do not respond to …

radiopharmaceutical therapy
measurable disease
hodgkin's disease
platelet transfusion
interleukins
  • 131 views
  • 02 Dec, 2021
  • 82 locations
None
Olaparib in Treating Patients With Advanced Glioma Cholangiocarcinoma or Solid Tumors With IDH1 or IDH2 Mutations

This phase II trial studies how well olaparib works in treating patients with glioma, cholangiocarcinoma, or solid tumors with IDH1 or IDH2 mutations that have spread to other places in the body (metastatic) and usually cannot be cured or controlled with treatment (refractory). Olaparib may stop the growth of tumor …

solid tumor
olaparib
solid tumour
angiogenesis inhibitor
blood transfusion
  • 110 views
  • 19 Nov, 2021
  • 25 locations
None
Volitinib in Treating Patients With Recurrent or Refractory Primary CNS Tumors

This phase I trial studies the side effects and best dose of volitinib in treating patients with primary central nervous system (CNS) tumors that have come back (recurrent) or does not respond to treatment (refractory). Volitinib may stop the growth of tumor cells by blocking some of the enzymes needed …

  • 4 views
  • 12 Nov, 2021
  • 10 locations
None
Genetically Modified T-cells in Treating Patients With Recurrent or Refractory Malignant Glioma

This phase I trial studies the side effects and best dose of genetically modified T-cell immunotherapy in treating patients with malignant glioma that has come back (recurrent) or has not responded to therapy (refractory). A T cell is a type of immune cell that can recognize and kill abnormal cells …

tumor cells
immunohistochemistry
nitrosoureas
temodar
measurable disease
  • 60 views
  • 19 Feb, 2021
  • 2 locations
None
Chemotherapy and Donor Stem Transplant for the Treatment of Patients With High Grade Brain Cancer

This phase I trial investigates the side effects and effectiveness of chemotherapy followed by a donor (allogeneic) stem cell transplant when given to patients with high grade brain cancer. Chemotherapy drugs, such as fludarabine, thiotepa, etoposide, melphalan, and rabbit anti-thymocyte globulin, work in different ways to stop the growth of …

  • 0 views
  • 02 Mar, 2021
  • 1 location
None
Larotrectinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors Non-Hodgkin Lymphoma or Histiocytic Disorders With NTRK Fusions (A Pediatric MATCH Treatment Trial)

This phase II Pediatric MATCH trial studies how well larotrectinib works in treating patients with solid tumors, non-Hodgkin lymphoma, or histiocytic disorders with NTRK fusions that have spread to other places in the body and have come back or do not respond to treatment. Larotrectinib may stop the growth of …

radiopharmaceutical therapy
measurable disease
hodgkin's disease
platelet transfusion
interleukins
  • 352 views
  • 03 Dec, 2021
  • 84 locations
None
Selpercatinib for the Treatment of Advanced Solid Tumors Lymphomas or Histiocytic Disorders With Activating RET Gene Alterations a Pediatric MATCH Treatment Trial

This phase II pediatric MATCH trial studies how well selpercatinib works in treating patients with solid tumors that have spread to other places in the body (advanced), lymphomas, or histiocytic disorders that have activating RET gene alterations. Selpercatinib may block the growth of cancer cells that have specific genetic changes …

radiopharmaceutical therapy
measurable disease
platelet transfusion
interleukins
nitrosourea
  • 18 views
  • 03 Dec, 2021
  • 90 locations
None
Ivosidenib in Treating Patients With Advanced Solid Tumors Lymphoma or Histiocytic Disorders With IDH1 Mutations (A Pediatric MATCH Treatment Trial)

This phase II Pediatric MATCH trial studies how well ivosidenib works in treating patients with solid tumors that have spread to other places in the body (advanced), lymphoma, or histiocytic disorders that have IDH1 genetic alterations (mutations). Ivosidenib may block the growth of cancer cells that have specific genetic changes …

radiopharmaceutical therapy
measurable disease
platelet transfusion
interleukins
nitrosourea
  • 37 views
  • 02 Dec, 2021
  • 90 locations
None
Tipifarnib for the Treatment of Advanced Solid Tumors Lymphoma or Histiocytic Disorders With HRAS Gene Alterations a Pediatric MATCH Treatment Trial

This phase II pediatric MATCH trial studies how well tipifarnib works in treating patients with solid tumors that have recurred or spread to other places in the body (advanced), lymphoma, or histiocytic disorders, that have a genetic alteration in the gene HRAS. Tipifarnib may block the growth of cancer cells …

radiopharmaceutical therapy
measurable disease
platelet transfusion
interleukins
nitrosourea
  • 20 views
  • 01 Dec, 2021
  • 90 locations
None
Olaparib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors Non-Hodgkin Lymphoma or Histiocytic Disorders With Defects in DNA Damage Repair Genes (A Pediatric MATCH Treatment Trial)

This phase II Pediatric MATCH trial studies how well olaparib works in treating patients with solid tumors, non-Hodgkin lymphoma, or histiocytic disorders with defects in deoxyribonucleic acid (DNA) damage repair genes that have spread to other places in the body (advanced) and have come back (relapsed) or do not respond …

hodgkin's disease
tumor markers
nitrosoureas
antineoplastic
cytokines
  • 199 views
  • 02 Dec, 2021
  • 76 locations