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Found 71 clinical trials
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Study of DSP-0390 in Patients With Recurrent High-Grade Glioma

This is a study of DSP-0390 in patients with recurrent high grade glioma.

aptt
sargramostim
dexamethasone
corticosteroids
  • 0 views
  • 28 Nov, 2021
  • 5 locations
None
Oncolytic Adenovirus DNX-2401 in Treating Patients With Recurrent High-Grade Glioma

This phase I trial studies best dose and side effects of oncolytic adenovirus DNX-2401 in treating patients with high-grade glioma that has come back (recurrent). Oncolytic adenovirus DNX-2401 is made from the common cold virus that has been changed in the laboratory to make it less likely to cause an …

gliosarcoma
temozolomide
nitrosoureas
recurrent tumor
brain tumor
  • 2 views
  • 07 May, 2021
  • 1 location
None
Trial of Niraparib in Participants With Newly-diagnosed Glioblastoma and Recurrent Glioma

This is an open-label, multi-center Phase 0 study with an expansion phase that will enroll up to 24 participants with newly-diagnosed glioblastoma and up to 18 recurrent glioma participants with

measurable disease
neutrophil count
renal function
platelet count
IDH2
  • 0 views
  • 10 Nov, 2021
  • 2 locations
None
Ketoconazole Before Surgery in Treating Patients With Recurrent Glioma or Breast Cancer Brain Metastases

This trial studies the side effects and how well ketoconazole works before surgery in treating patients with glioma that has come back or breast cancer that has spread to the brain. Ketoconazole is an antifungal drug that may be able to block a protein, tGLI1 and may help to treat …

metastasis
initial diagnosis
oligodendroglioma
ependymoma
brain tumor
  • 3 views
  • 06 Oct, 2021
  • 1 location
None
Precise DCE-MRI in Diagnosing Participants With Recurrent High Grade Glioma or Melanoma Brain Metastases

Dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) is a potentially powerful diagnostic tool for the management of brain cancer and other conditions in which the blood-brain barrier is compromised. This trial studies how well precise DCE MRI works in diagnosing participants with high grade glioma that has come back or …

  • 0 views
  • 26 Oct, 2021
  • 1 location
None
Open-label Study Investigating of OKN-007 Combined With Temozolomide in Patients With Recurrent Glioblastoma

This is a phase II open-label study investigating the efficacy, safety and pharmacokinetic(PK) properties of OKN-007 combined with temozolomide(TMZ) in patients with recurrent glioblastoma(GBM). All patients will have been previously treated with the standard-of-care treatment which includes surgical resection, radiation and chemotherapy, and in some cases treatment for recurrent disease. …

  • 15 views
  • 24 Nov, 2021
  • 9 locations
None
MRE Scan for the Assessment of Differences in Tissue Stiffness Between Radiation Necrosis and Recurrent Glioma in Patients With Previously Treated Gliomas

recurrent glioma post treatment and ultimately lead to a more accurate diagnosis and/or surgery, and/or a better assessment of the disease's response to treatment.

intracranial glioma
flair
MRI
recurrent glioma
  • 0 views
  • 27 Sep, 2021
  • 1 location
None
A Phase 0 /II Study of Ribociclib (LEE011) in Combination With Everolimus in Preoperative Recurrent High-Grade Glioma Patients Scheduled for Resection

In the proposed trial, patients will be administered ribociclib+everolimus prior to surgical resection of their tumor. Recurrent GBM patients will be randomized into one of the three time-interval cohorts for the first two dose levels. In the lead-in dose escalation study, the first six subjects (lead-in) will receive ribociclib 400 …

recurrent malignant glioma
temozolomide
PTEN
EGFR
contrast-enhanced magnetic resonance imaging
  • 7 views
  • 28 Mar, 2021
  • 3 locations
None
HUMC 1612: Optune NovoTTF-200A System

The purpose of this study is to determine if the Optune NovoTTF-200A device can be safely used in combination with chemotherapy in pediatric patients with recurrent high-grade glioma and

metastasis
gliosarcoma
temozolomide
ependymoma
tumor progression
  • 3 views
  • 22 Aug, 2021
  • 2 locations
None
ONC201 in Adults With Recurrent H3 K27M-mutant Glioma

The primary objective of this phase II trial is to determine the efficacy and safety of ONC201, an oral small molecule imipridone DRD2 antagonist, in adult subjects with recurrent high-grade

MRI
recurrent malignant glioma
brain mri
temozolomide
corticosteroids
  • 24 views
  • 18 Sep, 2021
  • 9 locations