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Found 71 clinical trials
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Oncolytic Adenovirus DNX-2401 in Treating Patients With Recurrent High-Grade Glioma

This phase I trial studies best dose and side effects of oncolytic adenovirus DNX-2401 in treating patients with high-grade glioma that has come back (recurrent). Oncolytic adenovirus DNX-2401 is made from the common cold virus that has been changed in the laboratory to make it less likely to cause an …

astrocytoma
lomustine
cancer
therapeutic conventional surgery
gliosarcoma
  • 2 views
  • 07 May, 2021
  • 1 location
None
BGB-290 and Temozolomide in Treating Patients With Recurrent Gliomas With IDH1/2 Mutations

by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving BGB-290 and temozolomide may work better in treating patients with recurrent gliomas.

carcinoma in situ
lomustine
cancer
therapeutic conventional surgery
corticosteroids
  • 1 views
  • 17 Sep, 2021
  • 17 locations
None
INCMGA00012 and Epacadostat in Combination With Radiation and Bevacizumab in Patients With Recurrent Gliomas

In this study, the investigators propose to combine INCMGA00012 with radiation therapy (RT) and bevacizumab with or without epacadostat in the treatment of recurrent glioblastoma (GBM). The investigators hypothesize that this combination provides a powerful synergy between RT and immune modulators to produce more robust anti-tumor immune response, induce tumor …

aptt
immunotherapeutic agent
blood transfusion
gliosarcoma
karnofsky performance status
  • 0 views
  • 06 Nov, 2021
  • 4 locations
None
Study of Recombinant Human Endostatin Combined With Temozolomide and Irinotecan in Recurrent Gliomas

treatment with irinotecan-based chemotherapy regimen, the PFS-6% of recurrent lower-grade gliomas was 40%. The optimal chemotherapeutics of recurrent gliomas has yet to be determined. Anti

  • 0 views
  • 27 Jan, 2021
  • 1 location
None
Study of Sonodynamic Therapy in Participants With Recurrent High-Grade Glioma

A Phase 0 single center, first in human, open-label study of ascending energy doses of sonodynamic therapy (SDT) utilizing the MRgFUS combined with intravenous ALA to assess safety and efficacy in up to 30 participants with recurrent HGG. Eligible participants who are scheduled for resection will be administered intravenous (IV) …

  • 0 views
  • 29 Mar, 2021
  • 1 location
None
Personalized Chimeric Antigen Receptor T Cell Immunotherapy for Patients With Recurrent Malignant Gliomas

without anti-PDL1 antibody) personalized immunotherapy for patients with recurrent malignant gliomas based on the expression of tumor specific/associated antigens (EGFRVIII, IL13R2, Her-2, EphA2, CD133

malignant glioma
erbb2
karnofsky performance status
prothrombin
immunohistochemistry
  • 13 views
  • 20 Jun, 2021
  • 1 location
None
Contribution of Cerebral 18F-DOPA PET-CT Scan in High-grade Recurrent Gliomas

. Several studies have used amino acid PET in the planning of radiotherapy treatment for high-grade gliomas, but without a well-conducted prospective study. In the recurrent high-grade glioma population, no

  • 0 views
  • 12 Aug, 2021
  • 1 location
None
Precise DCE-MRI in Diagnosing Participants With Recurrent High Grade Glioma or Melanoma Brain Metastases

Dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) is a potentially powerful diagnostic tool for the management of brain cancer and other conditions in which the blood-brain barrier is compromised. This trial studies how well precise DCE MRI works in diagnosing participants with high grade glioma that has come back or …

  • 0 views
  • 26 Oct, 2021
  • 1 location
None
Trial of Niraparib in Participants With Newly-diagnosed Glioblastoma and Recurrent Glioma

This is an open-label, multi-center Phase 0 study with an expansion phase that will enroll up to 24 participants with newly-diagnosed glioblastoma and up to 18 recurrent glioma participants with

neutrophil count
recurrent glioma
platelet count
EGFR
renal function
  • 0 views
  • 10 Nov, 2021
  • 2 locations
None
Study of DSP-0390 in Patients With Recurrent High-Grade Glioma

This is a study of DSP-0390 in patients with recurrent high grade glioma.

aptt
dexamethasone
sargramostim
corticosteroids
  • 0 views
  • 05 Dec, 2021
  • 5 locations