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Found 68 clinical trials
Study of Acetazolamide With Temozolomide in Adults With Newly Diagnosed or Recurrent Malignant Glioma

This is a Phase I study that examines the rate of dose limiting side effects in patients with malignant astrocytoma treated with combination acetazolamide (ACZ) and temozolomide (TMZ). Eligible patients must have histologically proven newly diagnosed, O6-methylguanine-DNA methyltransferase (MGMT) methylated WHO grade III or IV astrocytoma and be planning to …

  • 5 views
  • 22 Jun, 2021
  • 1 location
Phase 1 Trial of D2C7-IT in Combination With 2141-V11 for Recurrent Malignant Glioma

This is a phase 1 study of an anti-CD40 monoclonal antibody (2141-V11) in combination with D2C7-IT for patients with recurrent World Health Organization (WHO) grade III or IV malignant glioma at the Preston Robert Tisch Brain Tumor Center (PRTBTC) at Duke.

malignant glioma
brain tumor
recurrent malignant glioma
  • 0 views
  • 31 Jul, 2021
  • 1 location
Study of Vorasidenib (AG-881) in Participants With Residual or Recurrent Grade 2 Glioma With an IDH1 or IDH2 Mutation (INDIGO)

Study AG881-C-004 is a phase 3, multicenter, randomized, double-blind, placebo-controlled study comparing the efficacy of vorasidenib to placebo in participants with residual or recurrent Grade 2 glioma with an IDH1 or IDH2 mutation who have undergone surgery as their only treatment. Participants will be required to have central confirmation of …

  • 2 views
  • 20 Nov, 2021
  • 74 locations
Immunotherapy (Nivolumab and Ipilimumab) Before and After Surgery for the Treatment of Recurrent or Progressive High Grade Glioma in Children and Young Adults

This phase I trial studies the side effects of nivolumab and ipilimumab before and after surgery in treating children and young adults with high grade glioma that has come back (recurrent) or is increasing in scope or severity (progressive). Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help …

nitrosoureas
cytotoxic chemotherapy
platelet count
gilbert's syndrome
hematopoietic growth factors
  • 0 views
  • 30 Dec, 2021
  • 14 locations
Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Genetic tests look at the unique genetic …

liver metastasis
erdafitinib
copanlisib
crizotinib
neutrophil count
  • 6426 views
  • 19 Jan, 2022
  • 1030 locations
Infigratinib in Recurrent High-Grade Glioma Patients

This trial is an open-label, multicenter, Phase 0 trial that will enroll up to 20 participants with recurrent high-grade glioma with FGFR1 K656E or FGFR3 K650E mutation or FGFR3-TACC3

recurrent glioblastoma
recurrent malignant glioma
temozolomide
malignant glioma
renal function
  • 0 views
  • 28 Jan, 2021
  • 3 locations
D2C7-IT With Atezolizumab for Recurrent Gliomas

This is a phase 1 study of atezolizumab in combination with D2C7-IT, a dual-specific monoclonal antibody (mAB) with a high affinity for both EGFRwt- and EGFRvIII-expressing cells, in patients with recurrent World Health Organization (WHO) grade IV malignant glioma at the Preston Robert Tisch Brain Tumor Center (PRTBTC) at Duke.

brain tumor
brain mri with and without contrast
estrogen
brain mri
malignant glioma
  • 0 views
  • 16 May, 2021
  • 1 location
Study of Letrozole in Recurrent Gliomas

The purpose of this study is to determine the ability of letrozole to penetrate the blood brain barrier and concentrate in gliomas.

  • 12 views
  • 22 Sep, 2021
  • 1 location
CD147-CART Cells in Patients With Recurrent Malignant Glioma.

This is a single-center, single-arm, open label and dose escalation clinical study of anti-CD147 CART cells in patients with recurrent malignant glioma.

malignant glioma
glioblastoma multiforme
recurrent malignant glioma
measurable disease
  • 0 views
  • 24 Jan, 2021
  • 1 location
LITT Followed by Hypofractionated RT for Recurrent Gliomas

The purpose of this study is to evaluate the treatment regimen of using Laser Interstitial Thermal Therapy (LITT) and Hypo-fractionated Radiation Therapy to treat patients with recurrent gliomas

treatment regimen
MRI
brain mri
karnofsky performance status
recurrent tumor
  • 2 views
  • 02 Aug, 2021
  • 4 locations