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Found 98 clinical trials
OH2 Oncolytic Viral Therapy in Central Nervous System Tumors

intracavitary to tumor; to determine the phase II recommended dose (RP2D) of OH2 injection in the treatment of recurrent glioblastoma. Phase IIa, to evaluate the preliminary efficacy of OH2 injection in

  • 0 views
  • 22 Mar, 2022
  • 1 location
Surgical Nivolumab And Ipilimumab For Recurrent GBM

This research trial is studying the safety and effectiveness of nivolumab in combination with ipilimumab and surgery when used in the treatment of recurrent glioblastoma. The names of the

gliosarcoma
karnofsky performance status
recurrent glioblastoma
temozolomide
aptt
  • 0 views
  • 22 Mar, 2022
  • 2 locations
Retifanlimab and Epacadostat in Combination With Radiation and Bevacizumab in Patients With Recurrent Gliomas

In this study, the investigators propose to combine retifanlimab with radiation therapy (RT) and bevacizumab with or without epacadostat in the treatment of recurrent glioblastoma (GBM). The

blood transfusion
gliosarcoma
karnofsky performance status
astrocytoma
recurrent glioblastoma
  • 0 views
  • 28 Jul, 2022
  • 4 locations
Chimeric Antigen Receptor (CAR) T Cells With a Chlorotoxin Tumor-Targeting Domain for the Treatment of MPP2+ Recurrent or Progressive Glioblastoma

This phase I trial studies the side effects and best dose of chimeric antigen receptor (CAR) T cells with a chlorotoxin tumor-targeting domain in treating patients with MPP2+ glioblastoma that has come back (recurrent) or that is growing, spreading, or getting worse (progressive). Vaccines made from a gene-modified virus may …

mpp2
karnofsky performance status
serum pregnancy test
tumor cells
neutrophil count
  • 1 views
  • 28 Feb, 2022
  • 1 location
Study of Icapamespib (PU-AD) in Patients With Recurrent Malignant Glioma (Glio)

This is a 2-part multicenter Phase 1b study designed to test icapamespib in patients with recurrent brain lesions. Part 1 of the trial will be a standard 3 by 3 dose escalation design where different doses are examined. Part 2 will be a dose expansion cohort to further evaluate the …

  • 0 views
  • 30 May, 2022
  • 5 locations
A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer

This study will test an investigational drug called AZD1390 in combination with radiation therapy for the treatment of brain tumors. This is the first time AZD1390 is being given to patients. This study will test safety, tolerability and PK (how the drug is absorbed, distributed and eliminated) of ascending doses …

brain metastases
astrocytoma
stereotactic radiosurgery
MRI
antiepileptic
  • 127 views
  • 26 Jul, 2022
  • 7 locations
Trial of Anti-Tim-3 in Combination With Anti-PD-1 and SRS in Recurrent GBM

This phase I trial studies the side effects of stereotactic radiosurgery with MBG453 and spartalizumab in treating patients with recurrent glioblastoma multiforme (GBM). Stereotactic

contrast-enhanced magnetic resonance imaging
karnofsky performance status
gliosarcoma
recurrent glioblastoma
combined modality therapy
  • 6 views
  • 09 Aug, 2022
  • 2 locations
AZD1390 in Recurrent Grade IV Glioma Patients

This is an open-label, single-center Phase 0/1b study that will enroll at least 14 participants with recurrent WHO Grade IV Glioma requiring re-radiation. The trial will be composed of a Phase 0

levetiracetam
amylase
antiepileptic
temozolomide
neutrophil count
  • 0 views
  • 06 Apr, 2022
  • 1 location
Study of Pamiparib in Newly Diagnosed and rGBM

This is an open-label, single-center Phase 0/2 study that will enroll up to 30 participants with newly diagnosed (N=12) and recurrent glioblastoma (N=18). The trial will be composed of a Phase 0

measurable disease
temozolomide
recurrent glioblastoma
  • 0 views
  • 11 May, 2022
  • 1 location
Fluoroethyltyrosine in Detecting Tumors in Participants With Recurrent Intracranial Tumors

This phase II trial studies how well F-18 fluoroethyltyrosine (fluoroethyltyrosine) works in detecting tumors in participants with intracranial tumors that have come back. Imaging agents, such as fluoroethyltyrosine, may help doctors see the tumor better during a positron emission tomography (PET) scan.

positron emission tomography
MRI
pet scan
  • 1 views
  • 20 Apr, 2022
  • 1 location