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Found 107 clinical trials
[18F]DASA-23 and PET Scan in Evaluating Pyruvate Kinase M2 Expression in Patients With Intracranial Tumors or Recurrent Glioblastoma and Healthy Volunteers

recurrent glioblastoma and healthy volunteers. PKM2 regulates brain tumor metabolism, a key factor in glioblastoma growth. [18F]DASA-23 is a radioactive substance with the ability to monitor PKM2 activity

growth factor
MRI
karnofsky performance status
neutrophil count
glioblastoma multiforme
  • 111 views
  • 04 Mar, 2022
  • 1 location
Niraparib/TTFields in GBM

Evaluating the efficacy and safety of niraparib and Tumor-Treating Fields (TTFields) in recurrent glioblastoma (GBM).

supratentorial glioblastoma multiforme
renal function test
MRI
karnofsky performance status
glioblastoma multiforme
  • 12 views
  • 26 Jul, 2021
  • 1 location
B7-H3 CAR-T for Recurrent or Refractory Glioblastoma

This is a randomized, parallel-arm, phase I/II study to evaluate the safety and efficacy of B7-H3 CAR-T in between Temozolomide cycles comparing to Temozolomide alone in treating patients with glioblastoma that has come back or does not respond to the standard treatment. The antigen B7-H3 is highly expressed in glioblastoma …

aptt
temozolomide
neutrophil count
international normalized ratio
glioblastoma multiforme
  • 0 views
  • 25 Jan, 2021
  • 3 locations
IL13Ra2-CAR T Cells With or Without Nivolumab and Ipilimumab in Treating Patients With GBM

This phase I trial studies the side effects and how well IL13Ralpha2-CAR T cells work when given alone or together with nivolumab and ipilimumab in treating patients with glioblastoma that has come back (recurrent) or does not respond to treatment (refractory). Biological therapies, such as IL13Ralpha2-CAR T cells, use substances …

dexamethasone
temozolomide
neutrophil count
glioblastoma multiforme
measurable disease
  • 0 views
  • 11 Nov, 2021
  • 1 location
VB-111 in Surgically Accessible Recurrent/Progressive GBM

This research study is studying a new viral cancer therapy, ofranergene obadenovec (VB-111), for recurrent or progressive glioblastoma (GBM), a brain tumor that is growing or progressing despite earlier treatment.

dexamethasone
temozolomide
neutrophil count
glioblastoma multiforme
measurable disease
  • 0 views
  • 15 Jun, 2022
  • 1 location
Verteporfin for the Treatment of Recurrent High Grade EGFR-Mutated Glioblastoma

This phase I/II trial studies the side effects and best dose of Visudyne (liposomal verteporfin) and to see how well it works in treating patients with high grade EGFR-mutated glioblastoma that has come back (recurrent). Visudyne is FDA approved in combination with light to treat eye diseases. In this study …

EGFR
bevacizumab
MRI
temozolomide
cancer
  • 0 views
  • 14 Mar, 2022
  • 1 location
ASP8374 + Cemiplimab in Recurrent Glioma

This study is looking at the safety and efficacy of the drug combination of ASP8374 with cemiplimab in people with recurrent malignant glioma. The study will be conducted in two parts, the first portion of the study will be to establish the highest dose of ASP8374 that can be given …

malignant glioma
recurrent malignant glioma
  • 0 views
  • 14 Jul, 2022
  • 2 locations
A Dose Finding Study of [177Lu]Lu-DOTA-TATE in Newly Diagnosed Glioblastoma in Combination With Standard of Care and in Recurrent Glioblastoma as a Single Agent.

This study aims to establish the recommended dose of [177Lu]Lu-DOTA-TATE in combination with the standard of care or as single agent in three different groups of participants with Glioblastoma. In addition, this study will investigate the safety of [68Ga]Ga-DOTA-TATE and describe its uptake characteristics in participants with Glioblastoma.

MRI
recurrent disease
temozolomide
recurrent glioblastoma
  • 0 views
  • 21 Jul, 2022
  • 5 locations
A Study Testing the Effect of Immunotherapy (Ipilimumab and Nivolumab) in Patients With Recurrent Glioma With Elevated Mutational Burden

the chance of recurrent glioblastoma with high number of mutations from growing or spreading compared to usual care (surgery or chemotherapy).

  • 0 views
  • 29 Jul, 2022
  • 114 locations
OH2 Oncolytic Viral Therapy in Central Nervous System Tumors

intracavitary to tumor; to determine the phase II recommended dose (RP2D) of OH2 injection in the treatment of recurrent glioblastoma. Phase IIa, to evaluate the preliminary efficacy of OH2 injection in

  • 0 views
  • 22 Mar, 2022
  • 1 location