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Found 103 clinical trials
DNX-2440 Oncolytic Adenovirus for Recurrent Glioblastoma

Patients with first or second recurrence of GBM will be treated with stereotactic injection of the oncolytic virus DNX-2440.

dexamethasone
recurrent tumor
measurable disease
recurrent glioblastoma
gliosarcoma
  • 22 views
  • 15 Feb, 2022
  • 1 location
Sulfasalazine and Stereotactic Radiosurgery for Recurrent Glioblastoma (SAS-GKRS)

This study evaluates the safety associated with the addition of sulfasalazine to stereotactic radiosurgery for recurrent glioblastoma. Sulfasalazine is a potential tumor selective

glioblastoma multiforme
gilbert's syndrome
neutrophil count
temozolomide
recurrent glioblastoma
  • 3 views
  • 01 Mar, 2022
  • 1 location
A Study of Abemaciclib in Recurrent Glioblastoma

This research study is studying a targeted therapy as a possible treatment for recurrent glioblastoma (GBM). The following intervention will be used in this study: -Abemaciclib

neutrophil count
astrocytoma
cytotoxic chemotherapy
recurrent glioblastoma
aptt
  • 357 views
  • 27 Jan, 2022
  • 4 locations
AB154 Combined With AB122 for Recurrent Glioblastoma

This is a phase 0/I exploratory study. Patients at first or second recurrence of glioblastoma will be enrolled. The study will be divided into two cohorts: Cohort A (safety cohort) and Cohort B (surgical patient cohort). Cohort A: Eligible patients will be sequentially enrolled to receive intravenous AB154 combined with …

recurrent tumor
neutrophil count
MRI
recurrent glioblastoma
aptt
  • 0 views
  • 23 Jul, 2021
  • 1 location
Role of Repeat Resection in Recurrent Glioblastoma

Patients with recurrent Glioblastoma (GBM) are commonly presented to surgeons, along with the question of whether or not to re-resect the recurrence. There is no Level 1 evidence to support a

  • 0 views
  • 21 Apr, 2022
Protein Phosphatase 2A Inhibitor, in Recurrent Glioblastoma

Background The brain is separated from the rest of the blood stream by the blood-brain barrier. This is like a filter that protects the brain. But is also a challenge when medicines need to get into the brain. Researchers want to give the new drug LB100 to people before brain …

glioblastoma multiforme
astrocytoma
recurrent glioblastoma
gliosarcoma
renal function
  • 22 views
  • 17 Jun, 2022
  • 1 location
TTFields and Radiosurgery of Recurrent Glioblastoma +/- 18F-Fluoro-Ethyl-Thyrosine

All patients will receive TTFields therapy and additionally Stereotactic Radiosurgery . Radiosurgery will be based on MRI and FET-PET or MRI alone. Addition of FET-PET will be preferred option.

  • 0 views
  • 27 Jan, 2021
  • 1 location
Natural Progesterone for the Treatment of Recurrent Glioblastoma

This early phase I trial identifies the best dose, possible benefits and/or side effects of natural progesterone in treating patients with glioblastoma that has come back (recurrent). Progesterone is a type of hormone made by the body that plays a role in the menstrual cycle and pregnancy. Progesterone may help …

neutrophil count
MRI
recurrent glioblastoma
gliosarcoma
karnofsky performance status
  • 0 views
  • 30 Apr, 2022
  • 1 location
Intra-tumoral Ipilimumab Plus Intravenous Nivolumab Following the Resection of Recurrent Glioblastoma (GlitIpNi)

Phase I clinical trial on intra-tumoral ipilimumab plus intravenous nivolumab following the resection of recurrent glioblastoma. The aim of this clinical trial is to exploit the potential

neutrophil count
blood transfusion
temozolomide
MRI
recurrent glioblastoma
  • 146 views
  • 25 Feb, 2022
  • 1 location
Bevacizumab Alone Versus Dose-dense Temozolomide Followed by Bevacizumab for Recurrent Glioblastoma, Phase III (RE-GEND)

The aim of this Phase III study is to evaluate the superiority of dose-dense temozolomide (ddTMZ) followed by bevacizumab at ddTMZ failure for glioblastoma at first recurrence or progression, comparing to bevacizumab alone.

astrocytoma
bevacizumab
recurrent glioblastoma
neutron capture therapy
astrocytoma, anaplastic
  • 541 views
  • 24 Feb, 2022
  • 35 locations