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Found 102 clinical trials
Surgery for Recurrent Glioblastoma (RESURGE)

> However, evidence for a survival benefit of surgery for recurrent glioblastoma is scarce and relies entirely on retrospective analyses. While most retrospective analyses report an apparent survival

recurrent glioblastoma
tumour resection
MRI
temozolomide
  • 145 views
  • 27 May, 2022
  • 18 locations
Phase 1 Trial of D2C7-IT in Combination With 2141-V11 for Recurrent Malignant Glioma

This is a phase 1 study of an anti-CD40 monoclonal antibody (2141-V11) in combination with D2C7-IT for patients with recurrent World Health Organization (WHO) grade III or IV malignant glioma at the Preston Robert Tisch Brain Tumor Center (PRTBTC) at Duke.

malignant glioma
brain tumor
recurrent malignant glioma
  • 0 views
  • 31 Jul, 2021
  • 1 location
Effectiveness of MR-guided LITT Therapy in Irresectable Glioblastoma (EMITT) (EMITT)

The aim of this study is to investigate the (cost-)effectiveness of LITT (Laser Interstitial Thermal Therapy) in primary irresectable glioblastoma. Glioblastoma are the most common malignant brain tumors and are, due to their devastating nature and the fact that these tumors occur at a relatively young age (median 59 years), …

  • 0 views
  • 30 Apr, 2022
  • 1 location
Ph I/II Study of NMS-03305293+TMZ in Adult Patients With Recurrent Glioblastoma

(Phase 1) and isocitrate dehydrogenase (IDH) wild type recurrent glioblastoma (glioblastoma expansion cohort in Phase 1 and Phase 2).

lomustine
measurable disease
MRI
astrocytoma
temozolomide
  • 0 views
  • 05 Apr, 2022
  • 4 locations
A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma (GBM AGILE)

Glioblastoma (GBM) adaptive, global, innovative learning environment (GBM AGILE) is an international, seamless Phase II/III response adaptive randomization platform trial designed to evaluate multiple therapies in newly diagnosed (ND) and recurrent GBM.

gliosarcoma
MRI
karnofsky performance status
temozolomide
recurrent glioblastoma
  • 107 views
  • 04 Jun, 2022
  • 36 locations
First-in-Human, Phase 1b/2a Trial of a Multipeptide Therapeutic Vaccine in Patients With Progressive Glioblastoma

The purpose of this study is to assess the safety, tolerability, immunogenicity, and preliminary efficacy of EO2401 in patients with unequivocal evidence of progressive or first recurrent

  • 0 views
  • 17 Dec, 2021
  • 14 locations
Immunotherapy (Nivolumab and Ipilimumab) Before and After Surgery for the Treatment of Recurrent or Progressive High Grade Glioma in Children and Young Adults

This phase I trial studies the side effects of nivolumab and ipilimumab before and after surgery in treating children and young adults with high grade glioma that has come back (recurrent) or is increasing in scope or severity (progressive). Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help …

ipilimumab
neutrophil count
nitrosoureas
interferon
hematopoietic growth factors
  • 72 views
  • 03 May, 2022
  • 17 locations
Effect of Tumor Treating Fields (TTFields, 150 kHz) as Front-Line Treatment of Locally-advanced Pancreatic Adenocarcinoma Concomitant With Gemcitabine and Nab-paclitaxel (PANOVA-3)

Brief Summary: The study is a prospective, randomized controlled phase III trial aimed to test the efficacy and safety of Tumor Treating Fields (TTFields) in combination with gemcitabine and nab-paclitaxel, for front line treatment of locally-advanced pancreatic adenocarcinoma.The device is an experimental, portable, battery operated device for chronic administration of …

advanced pancreatic adenocarcinoma
cancer
gemcitabine
paclitaxel
metastasis
  • 440 views
  • 05 Jun, 2022
  • 121 locations
Pivotal, Open-label, Randomized Study of Radiosurgery With or Without Tumor Treating Fields (TTFields) for 1-10 Brain Metastases From Non-small Cell Lung Cancer (NSCLC).

The study is a prospective, randomized controlled phase III trial, to test the efficacy, safety and neurocognitive outcomes of advanced NSCLC patients, following stereotactic radiosurgery (SRS) for 1 inoperable brain metastasis or 2-10 brain metastases, treated with NovoTTF-200M and supportive treatment compared to supportive treatment alone. The device is an …

  • 19 views
  • 06 Jun, 2022
  • 103 locations
Sacituzumab Govitecan in Recurrent Glioblastoma

This is an open-label single arm study. All patients will receive the investigational agent.

methylated
MRI
temozolomide
recurrent glioblastoma
platelet count
  • 0 views
  • 21 Mar, 2022
  • 1 location