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Found 23 clinical trials
Immune Checkpoint Inhibition With Lurbinectedin Relapsed/Recurrent SCLC

plus lurbinectedin in patients with relapsed/recurrent small cell lung cancer after progression with first-line, platinum-based chemotherapy

oophorectomy
platinum-based chemotherapy
measurable disease
lurbinectedin
nivolumab
  • 0 views
  • 22 Jul, 2021
  • 2 locations
Topotecan Plus M6620 (VX-970) vs. Topotecan Alone in People With Relapsed Small-Cell Lung Cancer

Background Small cell cancers are aggressive and grow fast. They can appear in the lungs and in other parts of the body. These tumors often don t respond well to treatment if they come back after chemotherapy. Treatment with two drugs combined may be able to help. Objective To compare …

topotecan
  • 1 views
  • 18 Nov, 2019
  • 1 location
AZD2811 and Durvalumab (MEDI4736) Combination Therapy in Relapsed Small Cell Lung Cancer

Samsung Medical Centre, Seoul, Korea. Additional 0~5 Korea Lung Cancer Consortium (KLCC) centres in Korea Up to 40 subjects will be enrolled in two-stages (first stage: 19 evaluable subjects and second stage: 17 evaluable subjects and additional 4 subjects considering the drop out rate) If the study is conducted as …

neutrophil count
serum pregnancy test
hysterectomy
measurable disease
liver metastasis
  • 0 views
  • 27 Apr, 2021
DS-3201b and Irinotecan for Patients With Recurrent Small Cell Lung Cancer

This study will test the safety of the study drug, DS-3201b, given in combination with irinotecan to people who have recurrent small cell lung cancer (SCLC).

neutrophil count
irinotecan
anticoagulants
measurable disease
liver metastasis
  • 5 views
  • 10 Mar, 2021
  • 7 locations
Sequential Hypofractionated Radiotherapy Followed by Anti-PD-L1 Atezolizumab for SCLC

The investigators hypothesized that local radiation therapy can enhance the effect of anti-PD-L1 monoclonal antibody through priming T-cell effector function against cancer cells. Described as above, The investigators concluded that modest dose of radiation to local site prior to immunotherapy is the best to enhance T-cell-mediated immunity. Accordingly, The investigators …

monoclonal antibodies
platinum-based chemotherapy
  • 1 views
  • 25 Jan, 2021
  • 1 location
A Study of PLM60 in Subjects With Relapsed Small-cell Lung Cancer After Platinum-based First-Line Chemotherapy

This is an open, multicenter phase II clinical study for PLM60. The primary aim of the study is to observe the initial efficacy of PLM60 in treatment of small cell lung cancer. The secondary aim is to explore the safety and PK characteristics of PLM60

cancer chemotherapy
measurable disease
  • 0 views
  • 24 Jan, 2021
  • 1 location
A Phase I/II Study of Nivolumab Ipilimumab and Plinabulin in Patients With Recurrent Small Cell Lung Cancer

This is an open-label Phase I/II study, with a dose escalation part (Phase I) and a single-arm part (Phase II), in patients with recurrent SCLC who progressed after first-line platinum-based

neutrophil count
measurable disease
lung cancer
alopecia
absolute neutrophil count
  • 20 views
  • 02 Jun, 2021
  • 7 locations
A Single-arm Phase Clinical Trial of Anlotinib Hydrochloride Combined With Irinotecan or Docetaxel for Second Line Treatment of Nonsensitive Relapsed Small-cell Lung Cancer

cancer. This study intends to assess the efficacy and safety of anlotinib hydrochloride combined with irinotecan or docetaxel for second line treatment of nonsensitive relapsed small-cell lung cancer.

  • 0 views
  • 24 Feb, 2021
  • 1 location
Ipilimumab and Nivolumab in Recurrent Extensive Stage Small Cell Lung Cancer After Receiving Platinum-based Chemotherapy

This is a pilot study of patients who previously received platinum chemotherapy with recurrent SCLC to evaluate the change in the ratio of intratumoral Teff/Treg cells and clinical benefit of

chemoradiotherapy
measurable disease
metastasis
nivolumab
platinum-based chemotherapy
  • 0 views
  • 24 Jan, 2021
Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability

This phase III trial compares the effect of stereotactic radiosurgery to standard of care memantine and whole brain radiation therapy that avoids the hippocampus (the memory zone of the brain) for the treatment of small cell lung cancer that has spread to the brain. Stereotactic radiosurgery is a specialized radiation …

  • 0 views
  • 07 Jun, 2021
  • 1 location