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Found 60 clinical trials
Study of Acetazolamide With Temozolomide in Adults With Newly Diagnosed or Recurrent Malignant Glioma

This is a Phase I study that examines the rate of dose limiting side effects in patients with malignant astrocytoma treated with combination acetazolamide (ACZ) and temozolomide (TMZ). Eligible patients must have histologically proven newly diagnosed, O6-methylguanine-DNA methyltransferase (MGMT) methylated WHO grade III or IV astrocytoma and be planning to …

  • 6 views
  • 26 Apr, 2022
  • 1 location
Phase 1 Trial of D2C7-IT in Combination With 2141-V11 for Recurrent Malignant Glioma

This is a phase 1 study of an anti-CD40 monoclonal antibody (2141-V11) in combination with D2C7-IT for patients with recurrent World Health Organization (WHO) grade III or IV malignant glioma at the Preston Robert Tisch Brain Tumor Center (PRTBTC) at Duke.

malignant glioma
brain tumor
recurrent malignant glioma
  • 0 views
  • 31 Jul, 2021
  • 1 location
Immunotherapy (Nivolumab and Ipilimumab) Before and After Surgery for the Treatment of Recurrent or Progressive High Grade Glioma in Children and Young Adults

This phase I trial studies the side effects of nivolumab and ipilimumab before and after surgery in treating children and young adults with high grade glioma that has come back (recurrent) or is increasing in scope or severity (progressive). Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help …

malignant glioma
monoclonal antibodies
cancer
platelet count
gilbert's syndrome
  • 72 views
  • 03 May, 2022
  • 19 locations
Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)

This Pediatric MATCH screening and multi-sub-study phase II trial studies how well treatment that is directed by genetic testing works in pediatric patients with solid tumors, non-Hodgkin lymphomas, or histiocytic disorders that have progressed following at least one line of standard systemic therapy and/or for which no standard treatment exists …

brainstem tumor
nervous
alpha-fetoprotein
radiopharmaceutical therapy
chemotherapeutic agents
  • 1032 views
  • 25 Jul, 2022
  • 106 locations
Molecular Analysis for Therapy Choice (MATCH)

This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Genetic tests look at the unique genetic …

hypomagnesemia
osimertinib
ipatasertib
cancer treatment
white blood cells
  • 6575 views
  • 19 Aug, 2022
  • 912 locations
ASP8374 + Cemiplimab in Recurrent Glioma

This study is looking at the safety and efficacy of the drug combination of ASP8374 with cemiplimab in people with recurrent malignant glioma. The study will be conducted in two parts

malignant glioma
recurrent malignant glioma
  • 0 views
  • 14 Jul, 2022
  • 2 locations
Study of Letrozole in Recurrent Gliomas

The purpose of this study is to determine the ability of letrozole to penetrate the blood brain barrier and concentrate in gliomas.

  • 14 views
  • 25 Feb, 2022
  • 1 location
Infigratinib in Recurrent High-Grade Glioma Patients

This trial is an open-label, multicenter, Phase 0 trial that will enroll up to 20 participants with recurrent high-grade glioma with FGFR1 K656E or FGFR3 K650E mutation or FGFR3-TACC3

malignant glioma
amylase
renal function test
glioblastoma multiforme
FGFR3
  • 0 views
  • 28 Jan, 2021
  • 3 locations
D2C7-IT With Atezolizumab for Recurrent Gliomas

This is a phase 1 study of atezolizumab in combination with D2C7-IT, a dual-specific monoclonal antibody (mAB) with a high affinity for both EGFRwt- and EGFRvIII-expressing cells, in patients with recurrent World Health Organization (WHO) grade IV malignant glioma at the Preston Robert Tisch Brain Tumor Center (PRTBTC) at Duke.

malignant glioma
prothrombin
monoclonal antibodies
recurrent tumor
estrogen
  • 0 views
  • 06 Apr, 2022
  • 1 location
LITT Followed by Hypofractionated RT for Recurrent Gliomas (GCCC 19140)

The purpose of this study is to evaluate the treatment regimen of using Laser Interstitial Thermal Therapy (LITT) and Hypo-fractionated Radiation Therapy to treat patients with recurrent gliomas

MRI
treatment regimen
karnofsky performance status
recurrent tumor
brain mri
  • 2 views
  • 25 Feb, 2022
  • 3 locations