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Found 122 clinical trials
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GBM AGILE An International, Seamless Phase II/III Responsive Adaptive Randomization Platform Trial Designed To Evaluate Multiple Regimens in Newly Diagnosed and Recurrent GBM

People with either a new diagnosis of glioblastoma or with evidence that their tumor has returned or started to grow again may be eligible.  This trial is studying multiple treatment options, with the results of molecular testing on the tumor determining which arm(s) a person would qualify for.  This trial …

brain tumor
glioblastoma multiforme
  • 0 views
  • 24 Jun, 2021
  • 1 location
featured
CG01-GBM Standard Chemotherapy versus Chemotherapy Chosen by Cancer Stem Cell Chemosensitivity Testing in the Management of Patients with Recurrent Glioblastoma Multiforme (GBM)

People who were previously diagnosed with glioblastoma (Grade IV) or Grade III glioma, and now have evidence that their tumor has come back or has started to grow again, and who would otherwise be getting surgery or a biopsy as part of their treatment may be eligible.  At the time …

brain tumor
glioblastoma
  • 117 views
  • 24 Jun, 2021
  • 1 location
Hypofractionated Stereotactic Radiotherapy in Recurrent Glioblastoma Multiforme

. Reirradiation is an option in selected cases. The objective of this study is to compare 2 schemes of stereotactic hypofractionated radiotherapy in the management of recurrent GBM.

  • 15 views
  • 23 Jan, 2021
  • 1 location
Regorafenib in Bevacizumab Refractory Recurrent Glioblastoma

The purpose of this study is to determine the safety and tolerability of Regorafenib in patients with recurrent or progressive glioblastoma (GBM) who have progressed on bevacizumab. Regorafenib is FDA approved administered as monotherapy during the study. 22 total patients are expected to participate in this study. Even though a …

bevacizumab
cytotoxic chemotherapy
corticosteroids
gliosarcoma
temozolomide
  • 0 views
  • 01 Aug, 2021
  • 2 locations
Standard Chemotherapy vs. Chemotherapy Guided by Cancer Stem Cell Test in Recurrent Glioblastoma

brain tumors such as recurrent glioblastoma (GBM).

residual tumor
cancer
brain tumor
glioblastoma multiforme
neutrophil count
  • 33 views
  • 25 Jan, 2021
  • 15 locations
Improving Tumor Treating Fields Treatment for Brain Cancer Patients With Skullremodeling Surgery (Neurosurgery)

The aim of this trial is to test a new potential treatment, skullremodeling surgery (SR-surgery) combined with tumor treating fields (TTFields), for patients with first recurrence of malignant brain tumor (first recurrence of glioblastoma). Glioblastoma is one of the most malignant cancers. TTFields is a new treatment for brain cancer …

  • 0 views
  • 26 Jan, 2021
  • 1 location
Exablate Blood-Brain Barrier Disruption for the Treatment of rGBM in Subjects Undergoing Carboplatin Monotherapy

The purpose of this study is to evaluate the safety and feasibility of the Exablate Model 4000 Type 2 system when used as a tool to open the blood-brain-barrier (BBB) in subjects with recurrent

  • 0 views
  • 07 Jun, 2021
  • 4 locations
Exablate Blood-Brain Barrier Disruption With Carboplatin for the Treatment of rGBM

The purpose of this study is to evaluate the safety and feasibility of the Exablate Model 4000 Type 2 system when used as a tool to open the blood-brain-barrier (BBB) in subjects with recurrent

tumor progression
glioblastoma multiforme
  • 0 views
  • 01 Jun, 2021
  • 2 locations
Niraparib Combined With Radiotherapy in rGBM

Thirty patients were enrolled in this study, mainly patients with first recurrence of glioblastoma, and the requirement is that they can receive secondary radiotherapy. Regardless of whether the patient has received a second operation or the MGMT promoter is methylated, they can be included in this study. After enrollment, patients …

  • 0 views
  • 02 Feb, 2021
  • 1 location
Neoadjuvant PD-1 Antibody Alone or Combined With DC Vaccines for Recurrent Glioblastoma

Glioblastoma multiforme (GBM) are the most prevalent malignant tumor in central nervous system. At recurrence, no clear standard-of-care therapy is agreed for recurrent GBM (rGBM) and median

  • 0 views
  • 02 Aug, 2021
  • 1 location