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Found 18 clinical trials
Rucaparib vs Placebo Maintenance Therapy in Metastatic and Recurrent Endometrial Cancer

This study seeks to determine the effectiveness of Rucaparib as maintenance therapy for metastatic and recurrent endometrial cancer, after 1-2 prior lines of therapy.

  • 0 views
  • 14 Jul, 2022
  • 1 location
A Phase II Trial of Pembrolizumab Plus Olaparib for the Treatment of Patients With Persistent/Recurrent Endometrial Cancers

The purpose of this study is to find out whether the combination of pembrolizumab and olaparib is an effective treatment for people with persistent or recurrent endometrial cancer or endometrial

  • 0 views
  • 13 Oct, 2022
  • 3 locations
A Phase III Randomized, Placebo-Controlled Study of Pembrolizumab (MK-3475, NSC #776864) in Addition to Paclitaxel and Carboplatin for Measurable Stage III or IVA, Stage IVB or Recurrent Endometrial Cancer

This phase III trial studies how well the combination of pembrolizumab, paclitaxel and carboplatin works compared with paclitaxel and carboplatin alone in treating patients with endometrial cancer that is stage III or IV, or has come back (recurrent). Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune …

primary tumor
endometrioid adenocarcinoma
pembrolizumab
pelvic radiation
adenocarcinoma
  • 198 views
  • 21 Oct, 2022
  • 184 locations
  • 112 views
  • 25 Oct, 2022
  • 19 locations
A Phase 3 Randomized, Open-label, Active-comparator Controlled Clinical Study of Pembrolizumab Versus Platinum Doublet Chemotherapy in Participants With Mismatch Repair Deficient (dMMR) Advanced or Recurrent Endometrial Carcinoma in the First-line Setting (KEYNOTE-C93/GOG-3064/ENGOT-en15)

deficient (dMMR) advanced or recurrent endometrial carcinoma who have not previously been treated with prior systemic chemotherapy. The primary study hypotheses are that pembrolizumab is superior to

paclitaxel
docetaxel
pembrolizumab
carboplatin
mk-3475
  • 0 views
  • 22 Oct, 2022
  • 121 locations
Study of Lenvatinib w/ Pembro in Black Participants w/Mismatch Repair-Prof Recurrent Endometrial Cancer

Determine the efficacy of the combination of lenvatinib and pembrolizumab in Black participants compared to the efficacy reported in the historical trials leading to US FDA approval of the regimen

pembrolizumab
cancer
brain metastases
recurrent endometrial cancer
hormone therapy
  • 0 views
  • 04 May, 2022
  • 1 location
Testing Nivolumab With or Without Ipilimumab in Deficient Mismatch Repair System (dMMR) Recurrent Endometrial Carcinoma

. Giving nivolumab in combination with ipilimumab may be better than nivolumab alone in treating dMMR recurrent endometrial carcinoma.

  • 0 views
  • 07 Oct, 2022
  • 4 locations
Crizotinib in c-MET Mutation Metastatic/Recurrent/Persistent Endometrial Cancer

The majority of endometrial cancer patients with disease spread beyond the uterus will progress within 1 year. Platinum-based chemotherapy was used as the first-line treatment in metastatic or advanced endometrial cancer. There is no standard protocol for the second-line option when tumors persist or recur. In vitro and in vivo …

  • 0 views
  • 14 Jun, 2022
  • 1 location
VSV-hIFNbeta-NIS With or Without Ruxolitinib Phosphate in Treating Patients With Stage IV or Recurrent Endometrial Cancer

This phase I trial studies the side effects and best dose of vesicular stomatitis virus-human interferon beta-sodium iodide symporter (VSV-hIFNbeta-NIS) with or without ruxolitinib phosphate in treating patients with stage IV endometrial cancer or endometrial cancer that has come back. The study virus, VSV-hIFNbeta-NIS, has been changed so that it …

primary tumor
vesicular stomatitis
adenocarcinoma
chemotherapy regimen
carcinoma
  • 19 views
  • 04 Oct, 2022
  • 1 location
A Phase II, Randomized Two-Arm Study of Everolimus and Letrozole, +/- Ribociclib (LEE011) in Patients With Advanced or Recurrent Endometrial Carcinoma

This phase II trial studies how well everolimus and letrozole with or without ribociclib work in treating participants with endometrial cancer that has spread to other areas of the body or has come back. Ribociclib may stop the growth of tumor cells by blocking some of the enzymes needed for …

direct bilirubin
EGFR
liver metastasis
lee011
everolimus
  • 80 views
  • 18 Oct, 2022
  • 2 locations