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Found 19 clinical trials
Rucaparib vs Placebo Maintenance Therapy in Metastatic and Recurrent Endometrial Cancer

This study seeks to determine the effectiveness of Rucaparib as maintenance therapy for metastatic and recurrent endometrial cancer, after 1-2 prior lines of therapy.

  • 0 views
  • 11 May, 2021
  • 1 location
Durvalumab With or Without Olaparib as Maintenance Therapy After First-Line Treatment of Advanced and Recurrent Endometrial Cancer

patients with newly diagnosed advanced or recurrent endometrial cancer.

durvalumab
carboplatin
cancer
carcinosarcoma
paclitaxel
  • 104 views
  • 16 Jun, 2021
  • 193 locations
Testing the Addition of the Immunotherapy Drug Pembrolizumab to the Usual Chemotherapy Treatment (Paclitaxel and Carboplatin) in Stage III-IV or Recurrent Endometrial Cancer

This phase III trial studies how well the combination of pembrolizumab, paclitaxel and carboplatin works compared with paclitaxel and carboplatin alone in treating patients with endometrial cancer that is stage III or IV, or has come back (recurrent). Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune …

serum pregnancy test
monoclonal antibodies
serous adenocarcinoma
MRI
adenocarcinoma
  • 71 views
  • 19 Jun, 2021
  • 173 locations
Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) Versus Chemotherapy for Endometrial Carcinoma (ENGOT-en9 / MK-7902-001) - China Extension Study

The purpose of this study is to compare the efficacy of pembrolizumab + lenvatinib to chemotherapy in female participants with Stage III, IV, or recurrent endometrial carcinoma. It is

endometrial carcinoma
carboplatin
hormone therapy
pembrolizumab
mk-3475
  • 0 views
  • 08 Jun, 2021
  • 17 locations
Maintenance With Selinexor/Placebo After Combination Chemotherapy in Participants With Endometrial Cancer [SIENDO]

participants with advanced or recurrent endometrial cancer. Participants with primary stage IV or recurrent disease who are in partial or complete response after having completed a single line of at least 12

remission
renal function
adjuvant therapy
cancer
carcinosarcoma
  • 47 views
  • 04 Jun, 2021
  • 103 locations
ONC201 in Recurrent or Metastatic Type II Endometrial Cancer Endometrial Cancer

This is a a Simon's two-stage, non-randomized, open label, 2-arm Phase II trial of ONC201 in women with metastatic or recurrent Type II endometrial cancer who failed at least 1 prior chemotherapy regimen.

measurable disease
renal function
carcinosarcoma
neutrophil count
metastatic disease
  • 48 views
  • 16 May, 2021
  • 3 locations
Evaluating Cancer Response to Treatment With Abemaciclib and Fulvestrant in Women With Recurrent Endometrial Cancer

The purpose of this study is to determine the effectiveness of the combination of abemaciclib and fulvestrant in treating this type of cancer and to determine the types and severity of side effects caused by treatment with abemaciclib and fulvestrant.

serum pregnancy test
hormone therapy
systemic chemotherapy
alopecia
papillary serous adenocarcinoma
  • 17 views
  • 28 Mar, 2021
  • 8 locations
Carboplatin Paclitaxel With or Without Avelumab in Advanced or Recurrent Endometrial Cancer

This study aims to evaluate the safety and activity of the Avelumab in combination with Carboplatin-Paclitaxel in advanced or recurrent endometrial cancer

  • 0 views
  • 15 Mar, 2021
  • 10 locations
A Phase II Two-Arm Study of Everolimus and Letrozole +/- Ribociclib (Lee011) in Patients With Advanced or Recurrent Endometrial Carcinoma

This phase II trial studies how well everolimus and letrozole with or without ribociclib work in treating participants with endometrial cancer that has spread to other areas of the body or has come back. Ribociclib may stop the growth of tumor cells by blocking some of the enzymes needed for …

MRI
EGFR
metastatic disease
direct bilirubin
carcinoma
  • 80 views
  • 26 Jan, 2021
  • 3 locations
Abemaciclib for the Treatment of Recurrent Ovarian or Endometrial Cancer

This phase II trial studies how well abemaciclib works in treating patients with ovarian or endometrial cancer that has an activation of the CDK4/6 pathway and that has come back (recurrent). Abemaciclib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving …

  • 0 views
  • 26 Jan, 2021
  • 1 location