Found 763 clinical trials
A Randomized Phase 3 Study of MRTX849 in Combination with Cetuximab Versus Chemotherapy in Patients with Advanced Colorectal Cancer with KRAS G12C Mutation with Disease Progression On or After Standard First-Line Therapy (KRYSTAL-10)
Study 849-010 is an open-label, randomized Phase 3 clinical trial comparing the efficacy of MRTX849 administered in combination with cetuximab versus chemotherapy in the second-line treatment setting in patients with CRC with KRAS G12C mutation.
- 62 views
- 27 Apr, 2022
- 135 locations
What if there were a simpler way to find colorectal cancer?
ECLIPSE is being done to find out if a simple blood test can find early signs of colorectal cancer. Colorectal cancer is the #2 cause of death among adults with cancer, but it doesn’t have to be. If found early, it’s one of the most preventable and treatable cancers. NOW …
- 325 views
- 23 Mar, 2022
- 1 location
Alliance/NCCTG N1048: A Phase II/III Trial of Neoadjuvant FOLFOX, With Selective Use of Combined Modality Chemoradiation Versus Preoperative Combined Modality Chemoradiation for Locally Advanced Rectal Cancer Patients Undergoing Low Anterior Resection With Total Mesorectal Excision
Rectal Cancer Patients Undergoing Low Anterior Resection With Total Mesorectal Excision
- 114 views
- 08 Nov, 2020
- 1 location
Optimization of Preoperative Treatment in Locally Advanced Rectal Cancer
advanced rectal cancer. The hypothesis is 3-year disease-free survival in TNT group was non-inferior to that in CRT group.
- 0 views
- 21 Jul, 2021
- 1 location
Circulating Tumour DNA Based Decision for Adjuvant Treatment in Colon Cancer Stage II Evaluation
The CIRCULATE study evaluates the adjuvant therapy in patients with colon cancer UICC stage II. The primary aim of the study is to compare the disease free survival in patients who are positive for postoperative circulating tumour DNA with vs. without capecitabine.
- 0 views
- 24 Jan, 2021
Organ Preservation in Locally Advanced Rectal Cancer (PRONAR)
PRONAR trial aims to assess if treatment with organ preservation in stage II and III rectal cancer after a complete or almost complete response to neoadjuvant treatment is feasible and safe in
- 2 views
- 25 Feb, 2022
- 1 location
Dendrobium Huoshanense Suppository in Rectal Cancer
To evaluates the role of Dendrobium Huoshanense Suppository for radiation proctitis in locally advanced rectal cancer treated by capecitabine and irinotecan based neoadjuvant chemoradiation.
- 0 views
- 22 Oct, 2021
Induction Chemotherapy for Locally Recurrent Rectal Cancer
This is a multicentre, open-label, parallel arms, phase IIII study that randomises patients with locally recurrent rectal cancer in a 1:1 ratio to receive either induction chemotherapy followed
- 0 views
- 16 May, 2021
- 9 locations
Extended Resection for Rectal Cancer With Neoadjuvant Radiotherapy
Preoperative neoadjuvant therapy has become the guideline-recommended standard treatment for patients with locally advanced or mid-to-low rectal cancer with suspected regional lymph node
- 0 views
- 10 Mar, 2022
- 1 location
Neoadjuvant Therapy vs Standard Therapy in Locally Advanced Rectal Cancer (RECTUM2015)
Phase II, Multicenter, Open-label, Randomized Study evaluating neoadjuvant chemotherapy (FOLFOX4) in patients with stage II and III colorectal cancer with standard chemoradiation Defined by Magnetic Resonance Imaging
- 0 views
- 30 May, 2022