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Found 16 clinical trials
A Study to Investigate Safety of GS-248 and Efficacy on Raynauds' Phenomenon in Systemic Sclerosis

The primary objective of this study is to determine the safety, and evaluate the efficacy of GS-248 versus placebo on Raynaud's Phenomenon (RP) in subjects with Systemic Sclerosis (SSc).

  • 0 views
  • 17 Feb, 2021
  • 4 locations
Assess Efficacy of of Oral Treprostinil in Patients With Symptomatic Primary or Secondary Raynaud's Phenomenon

This study represents the first trial to assess the efficacy of oral treprostinil therapy in patients with symptomatic primary or secondary Raynaud's Phenomenon (RP) resistant to vasodilatory

calcium
vasodilator
tadalafil
phosphodiesterase inhibitors
vardenafil
  • 0 views
  • 25 Jan, 2021
  • 1 location
Apollo Device for Fatigue in Systemic Sclerosis

The purpose of this study is to learn about the effect of Apollo (a vibrating wearable about the side of an Apple Watch) on fatigue, Raynaud symptoms, depression, quality of life, and disease

  • 0 views
  • 01 May, 2021
  • 1 location
The Effect of High Dose Methylprednisolone on Nailfold in Early Systemic Sclerosis ( SSc )

This is a 12 week double-blind randomized placebo controlled trial in which 30 patients with very early SSc, fulfilling the Very Early Diagnosis Of Systemic Sclerosis (VEDOSS) criteria (9) will be randomized in a 2:1 fashion to receive intravenous methylprednisolone or placebo. Three-day treatment courses are given at week 0, …

progressive systemic sclerosis
raynaud's syndrome
  • 141 views
  • 23 Jan, 2021
  • 1 location
RElevance of UltraSonography for Assessing Salivary Gland Involvement in Systemic Sclerosis (SSc)

As fibrosis of salivary glands is supposed to be the main mechanism involved in Systemic sclerosis (SSc)-associated sicca syndrome, Ultrasonography , biopsy and measuring gland elasticity (by ARFI (Acoustic Radiation Force Impulse)) in SSc patients could also constitute a relevant method to assess the potential alterations of echostructure of major …

  • 0 views
  • 22 Apr, 2021
  • 3 locations
Cohort of Patients With Systemic Sclerosis Within the Framework of the RESO Reference Centre

Systemic sclerosis (SSc) is a rare form of connective tissue disease characterized by vascular involvement and the intensity of fibrosis. The lack of available treatment is largely due to the very fragmented understanding of the pathophysiology of SSc. However, one of the keys to conducting quality research on this disease …

scleroderma
progressive systemic sclerosis
fibrosis
rheumatism
  • 0 views
  • 15 May, 2021
  • 1 location
Temporary Celiac Ganglion Block as a Test Before Celiac Ganglion Resection for Dysautonomia-Related Bowel Dysmotility

Dysautonomia is malfunction of the autonomic nervous system. It usually results from overactivity of the sympathetic portion and over-secretion of acetylcholine. Symptoms depend on the organ involved by this sympathetic overstimulation. Involvement of the gastrointestinal system results in chronic dysmotility, nausea, vomiting, food intolerance, weight loss and need for feeding …

  • 8 views
  • 26 Apr, 2021
  • 1 location
Pharmacogenetic Study of Antiarrhythmic Drugs for Atrial Fibrillation

In this pilot and feasibility study, the investigators will enroll patients with frequent symptomatic episodes of atrial fibrillation (AF) in a cross-over study testing two different classes of anti arrhythmic drugs (AADs). This pilot and feasibility study will provide preliminary data for a larger study in which the investigators will …

antiarrhythmic drug
sotalol
flecainide
  • 64 views
  • 29 Apr, 2021
  • 4 locations
Analysis of Clinical Profiles of Chinese Patients With Normal Tension Glaucoma

To obtain demographic and baseline ophthalmic parameters (such as Intraocular Pressure profiles, disc morphological characteristics, central corneal thickness, peripapillary retinal nerve fibre layer thickness and its serial changes, visual field changes, severity of any medical associations—e.g. hypertension, migraine, strokes, silent cerebral infarcts) with non-invasive measurements, in Chinese Patients with Normal …

tension
intraocular pressure
low tension glaucoma
hypertension
  • 30 views
  • 07 Nov, 2020
  • 1 location
The Scleroderma Biorepository and Pathogenesis Study (STOP Scleroderma)

complications from their disease. Patients with confirmed scleroderma, raynauds or positive autoantibodies are invited to participate. This research may help us understand how to prevent and treat scleroderma

scleroderma
raynaud's syndrome
  • 125 views
  • 22 Jan, 2021
  • 1 location