Found 32 clinical trials
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Phase 3 trial
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Accepting Seniors
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Accepting adults
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100s of participants
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An interventional trial
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For females only
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Family Medicine
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Currently Recruiting
Boost Use in Breast Conservation Radiotherapy
This is a two arm randomized study for patients who are undergoing radiotherapy following breast conservation surgery for breast cancer. Local recurrence of breast cancer will be compared for patients receiving boost or no boost radiotherapy.
- 18 views
- 07 Nov, 2020
- 1 location
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Accepting Seniors
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Accepting adults
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1000s of participants
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An interventional trial
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For females only
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Currently Recruiting
One Week Versus Three Week in Adjuvant Radiotherapy in Breast Cancer
Background:Moderate three week hypofractionated adjuvant radiotherapy schedule is a standard care in breast cancers. A five day schedule has been demonstrated to be iso-toxic as a standard three week schedule. Recently studies have also demonstrated the safety and feasibility of simultaneous integrated boost in this setting. This randomized trial will …
- 1 views
- 24 Jan, 2021
- 1 location
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Multi-country trial
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Accepting Seniors
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Accepting adults
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100s of participants
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An interventional trial
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For females only
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Currently Recruiting
Early Detection of Cardiovascular Changes After Radiotherapy for Breast Cancer
Breast cancer (BC) radiotherapy leads to coincidental radiation of the heart, resulting in increased risk of a variety of heart diseases. Identifying BC patients with the highest risk of radiation-induced cardiac complications is crucial for developing strategies for primary and secondary prevention. Little has been done on the relationship between …
- 8 views
- 22 Jan, 2021
- 8 locations
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Accepting Seniors
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Accepting adults
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100s of participants
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An interventional trial
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For all genders
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Currently Recruiting
Carbon-Fibre Accessory (CARA) for Supine Breast Positioning to Reduce Toxicity in Whole Breast Radiotherapy
This trial is designed to assess the efficacy of a novel carbon-fibre adjustable reusable accessory (CARA) for breast support to reduce skin toxicity and unwanted normal tissue dose in comparison to the current clinical standard for supine breast support during whole breast RT.
- 0 views
- 25 Jan, 2021
- 1 location
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Phase 2 trial
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Accepting Seniors
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Accepting adults
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100s of participants
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An interventional trial
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For females only
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Currently Recruiting
Comparison of Acute Toxicity and Cost Between Whole Breast Irradiation With Sequential Boost and Simultaneous Integrated Boost After Breast Conserving Surgery.
Whole breast irradiation (WBI) after breast conserving surgery for early-stage breast cancer halves the recurrence risk and reduces the breast cancer death by about one sixth. A sequential boost (SeqB) dose to the tumour bed further improves local control, but also increases the risk of late skin toxicity and cosmetic …
- 3 views
- 08 Nov, 2020
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Phase 3 trial
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Accepting Seniors
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Accepting adults
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100s of participants
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An interventional trial
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For females only
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Currently Recruiting
Melatonin Supplementation for Cancer-related Fatigue in Patients Receiving Radiotherapy
This is a double-blind, placebo-controlled trial wherein subjects with breast cancer will be randomized to receive either 20 mg oral melatonin or placebo the night before their first RT, nightly throughout their RT, and for an additional 2 weeks following the completion of their RT. After informed consent is obtained …
- 2 views
- 26 Jan, 2021
- 1 location
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Accepting Seniors
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Accepting adults
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10s of participants
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An interventional trial
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For females only
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Family Medicine
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Currently Recruiting
Hypofractionated Radiotherapy After Breast Conserving Surgery
The optimal dose and fractionation regimen for whole breast irradiation, whole breast and regional nodal irradiation, and postmastectomy radiotherapy remains unknown. The goal of this phase II randomized controlled trial is to determine whether the hypofractionated proton regimens proposed are non-inferior compared with standard fractionated proton radiotherapy and therefore worthy …
- 6 views
- 08 Nov, 2020
- 2 locations
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Accepting Seniors
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Accepting adults
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1000s of participants
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An interventional trial
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For all genders
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Family Medicine
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Currently Recruiting
Axillary Management in Breast Cancer Patients With Needle Biopsy Proven Nodal Metastases After Neoadjuvant Chemotherapy
The aim of this study is to assess whether, omitting further axillary treatment (ALND and ART) for patients with early stage breast cancer and axillary nodal metastases on needle biopsy, who after NACT have no residual cancer in the lymph nodes on sentinel node biopsy, is non-inferior to axillary treatment …
- 0 views
- 27 Jan, 2021
- 2 locations
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Accepting Seniors
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Accepting adults
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1000s of participants
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An interventional trial
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For females only
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Family Medicine
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Currently Recruiting
Hypofractionated Vs Conventional Fractionated Radiotherapy After Breast Conserving Surgery
The study was designed to investigate whether hypofractionated radiotherapy(HF-RT) is noninferior to conventionally fractionated radiotherapy (CF-RT) in terms of tumor loco-regional control for patients after breast conserving surgery
- 2 views
- 23 Jan, 2021
- 4 locations
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Phase 3 trial
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Accepting Seniors
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Accepting adults
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100s of participants
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An interventional trial
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For all genders
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Family Medicine
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Currently Recruiting
Hypofractionated LocoRegional Radiotherapy in Breast Cancer
The primary objective is to determine if hypofractionated radiotherapy (RT) delivered over 1 week to the breast and regional nodes (supraclavicular, axillary and internal mammary) following breast conserving surgery (BCS), or to the chest wall and regional nodes following mastectomy, is non-inferior to conventional fractionation delivered over 3 weeks in …
- 0 views
- 14 Apr, 2021
- 4 locations