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Found 32 clinical trials
Boost Use in Breast Conservation Radiotherapy

This is a two arm randomized study for patients who are undergoing radiotherapy following breast conservation surgery for breast cancer. Local recurrence of breast cancer will be compared for patients receiving boost or no boost radiotherapy.

carcinoma in situ
ductal carcinoma in situ
breast cancer
cancer
carcinoma
  • 18 views
  • 07 Nov, 2020
  • 1 location
One Week Versus Three Week in Adjuvant Radiotherapy in Breast Cancer

Background:Moderate three week hypofractionated adjuvant radiotherapy schedule is a standard care in breast cancers. A five day schedule has been demonstrated to be iso-toxic as a standard three week schedule. Recently studies have also demonstrated the safety and feasibility of simultaneous integrated boost in this setting. This randomized trial will …

sentinel lymph node biopsy
mastectomy
breast cancer
cancer
sentinel node
  • 1 views
  • 24 Jan, 2021
  • 1 location
Early Detection of Cardiovascular Changes After Radiotherapy for Breast Cancer

Breast cancer (BC) radiotherapy leads to coincidental radiation of the heart, resulting in increased risk of a variety of heart diseases. Identifying BC patients with the highest risk of radiation-induced cardiac complications is crucial for developing strategies for primary and secondary prevention. Little has been done on the relationship between …

carcinoma in situ
breast-conserving surgery
breast cancer
cancer
ductal carcinoma
  • 8 views
  • 22 Jan, 2021
  • 8 locations
Carbon-Fibre Accessory (CARA) for Supine Breast Positioning to Reduce Toxicity in Whole Breast Radiotherapy

This trial is designed to assess the efficacy of a novel carbon-fibre adjustable reusable accessory (CARA) for breast support to reduce skin toxicity and unwanted normal tissue dose in comparison to the current clinical standard for supine breast support during whole breast RT.

  • 0 views
  • 25 Jan, 2021
  • 1 location
Comparison of Acute Toxicity and Cost Between Whole Breast Irradiation With Sequential Boost and Simultaneous Integrated Boost After Breast Conserving Surgery.

Whole breast irradiation (WBI) after breast conserving surgery for early-stage breast cancer halves the recurrence risk and reduces the breast cancer death by about one sixth. A sequential boost (SeqB) dose to the tumour bed further improves local control, but also increases the risk of late skin toxicity and cosmetic …

  • 3 views
  • 08 Nov, 2020
Melatonin Supplementation for Cancer-related Fatigue in Patients Receiving Radiotherapy

This is a double-blind, placebo-controlled trial wherein subjects with breast cancer will be randomized to receive either 20 mg oral melatonin or placebo the night before their first RT, nightly throughout their RT, and for an additional 2 weeks following the completion of their RT. After informed consent is obtained …

  • 2 views
  • 26 Jan, 2021
  • 1 location
Hypofractionated Radiotherapy After Breast Conserving Surgery

The optimal dose and fractionation regimen for whole breast irradiation, whole breast and regional nodal irradiation, and postmastectomy radiotherapy remains unknown. The goal of this phase II randomized controlled trial is to determine whether the hypofractionated proton regimens proposed are non-inferior compared with standard fractionated proton radiotherapy and therefore worthy …

adjuvant chemotherapy
breast-conserving surgery
  • 6 views
  • 08 Nov, 2020
  • 2 locations
Axillary Management in Breast Cancer Patients With Needle Biopsy Proven Nodal Metastases After Neoadjuvant Chemotherapy

The aim of this study is to assess whether, omitting further axillary treatment (ALND and ART) for patients with early stage breast cancer and axillary nodal metastases on needle biopsy, who after NACT have no residual cancer in the lymph nodes on sentinel node biopsy, is non-inferior to axillary treatment …

breast cancer staging
HER2
progesterone
estrogen
breast cancer
  • 0 views
  • 27 Jan, 2021
  • 2 locations
Hypofractionated Vs Conventional Fractionated Radiotherapy After Breast Conserving Surgery

The study was designed to investigate whether hypofractionated radiotherapy(HF-RT) is noninferior to conventionally fractionated radiotherapy (CF-RT) in terms of tumor loco-regional control for patients after breast conserving surgery

HER2
invasive breast cancer
erbb2
sentinel node
ki-67
  • 2 views
  • 23 Jan, 2021
  • 4 locations
Hypofractionated LocoRegional Radiotherapy in Breast Cancer

The primary objective is to determine if hypofractionated radiotherapy (RT) delivered over 1 week to the breast and regional nodes (supraclavicular, axillary and internal mammary) following breast conserving surgery (BCS), or to the chest wall and regional nodes following mastectomy, is non-inferior to conventional fractionation delivered over 3 weeks in …

  • 0 views
  • 14 Apr, 2021
  • 4 locations