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Found 47 clinical trials
Neoadjuvant PRRT With 177Lu-DOTATATE Followed by Surgery for Resectable PanNET

Peptide Receptor Radionuclide Therapy (PRRT) is based on specific somatostatin receptor targeting with radiolabelled analogues 90Y-DOTATOC and 177Lu-DOTATATE. These two most commonly used radiopeptides, 90Y-DOTATOC and 177Lu-DOTATATE, produce overall objective response rates of 15-35%. PRRT is generally well tolerated with mild toxicity, if the necessary precautions, such as the co-administration …

ct scan
metastasis
ki-67
pancreatic net
liver metastasis
  • 0 views
  • 05 Sep, 2021
  • 1 location
Evaluation of PET Probe [64]Cu-Macrin in Cardiovascular Disease Cancer and Sarcoidosis.

To evaluate the safety of [64Cu] Macrin and its whole-body distribution, metabolism, pharmacokinetics, and radiation burden in healthy volunteers. To detect [64Cu]-Macrin accumulation in sites of disease in subjects with cancer, sarcoidosis or myocardial infarct.

myocardial infarction
cancer
infarct
percutaneous coronary intervention
primary cancer
  • 0 views
  • 26 Sep, 2021
  • 1 location
RAdium-223 and SABR Versus SABR for Oligometastatic Prostate Cancers

This is a Phase II non-blinded randomized study evaluating men with oligometastatic prostate cancer lesions randomized (1:1) to stereotactic ablative radiation therapy (SABR) versus SBAR + Radium-223. We are looking to determine the progression-free survival of men who have oligometastatic prostate cancer with at least one bone metastasis with stereotactic …

testosterone
bone metastases
metastasis
neutrophil count
platelet count
  • 1 views
  • 15 May, 2021
  • 1 location
Role of Microglial Activation and Norepinephrine Transporter Abnormalities in Pathogenesis of MS-related Fatigue

The overarching aim is to assess the role of microglial activation and norepinephrine transporter binding in pathogenesis of MS-related fatigue, using novel Positron Emission Tomography (PET) radiotracers, [F-18]PBR06 and [C-11]MRB. Specific Aims: Specific Aim 1: To determine the relationship of cerebral microglial activation, as assessed by [F-18]PBR06 PET, with MS-related …

disease or disorder
atrophy
fatigue
  • 0 views
  • 06 Aug, 2021
  • 1 location
Novel Assessment of Synaptic Density in Progressive MS

The investigators propose to use the novel SV2a-PET ligand, [F-18]SDM-8 to assess synaptic density in progressive MS (including primary progressive multiple sclerosis (PPMS) and secondary progressive multiple sclerosis (SPMS)) as compared to relapsing-remitting multiple sclerosis (RRMS) patients and healthy controls, given its improved imaging characteristics and potential for large scale …

atrophy
secondary progressive multiple sclerosis
MRI
fatigue
  • 0 views
  • 30 Jul, 2021
  • 1 location
Study of Humidified Air to Improve Mucociliary Clearance (MCC) in COPD

This purpose of this study is to determine whether nasal delivery of heated and humidified air for a period of 4 hours will improve the clearance of mucus from the lungs of patients with chronic obstructive pulmonary disease (COPD). Mucus clearance will be measured using a nuclear medicine imaging procedure …

bronchitis
bronchodilator
  • 6 views
  • 28 Jan, 2021
  • 1 location
TheraSphere For Treatment of Metastases in Liver

To investigate whether the dose predicted by pre-therapy 99mTc MAA SPECT predicts the dose to the liver from the 90Y microspheres as assessed by post-therapy 90Y SPECT/CT or positron emission tomography (PET)/CT.

  • 0 views
  • 18 Apr, 2021
  • 1 location
Microglial Activation Positron Emission Tomography (PET) Brain Imaging in Multiple Sclerosis and Alzheimer's Disease

The specific aims of the study are: Primary: To determine the presence and regional distribution of microglial activation, as assessed by Fluorine-18 (18F) labeled "Peripheral Benzodiazepine Receptor 06" (PBR06) -PET, in subjects with active Relapsing Remitting Multiple Sclerosis (RRMS), Secondary Progressive Multiple Sclerosis (SPMS), and Alzheimer's Disease (AD) as compared …

atrophy
fatigue
disease or disorder
secondary progressive multiple sclerosis
benzodiazepines
  • 14 views
  • 26 Jan, 2021
  • 1 location
Fluorodopa F 18 in Congenital Hyperinsulinism and Insulinoma

Low blood sugars are known to cause brain damage in newborn babies. One of the most common causes of low blood sugars persisting beyond the new born period is a condition called congenital hyperinsulinism (HI). This is a disease whereby the pancreas secretes too much insulin and causes low blood …

  • 4 views
  • 23 Jan, 2021
  • 1 location
Molecular Imaging of Norepinephrine Transporter (NET) Using [C-11]Methylreboxetine PET in Multiple Sclerosis

This study aims to use [C-11]MRB PET (positron emission tomography) imaging to look at brain injury in patients with Multiple Sclerosis (MS) and healthy individuals. The overarching hypothesis is that there is decreased radioligand binding to the norepinephrine transporter in multiple sclerosis, reflecting injury to the noradrenergic system and that …

disease or disorder
MRI
fatigue
  • 9 views
  • 28 Jan, 2021
  • 1 location