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Found 32 clinical trials
Evaluation of PET Probe [64]Cu-Macrin in Cardiovascular Disease, Cancer and Sarcoidosis.

To evaluate the safety of [64Cu] Macrin and its whole-body distribution, metabolism, pharmacokinetics, and radiation burden in healthy volunteers. To detect [64Cu]-Macrin accumulation in sites of disease in subjects with cancer, sarcoidosis or myocardial infarct.

myocardial infarction
primary cancer
percutaneous coronary intervention
  • 07 Jul, 2022
  • 2 locations
RAdium-223 and SABR Versus SABR for Oligometastatic Prostate Cancers (RAVENS)

This is a Phase II non-blinded randomized study evaluating men with oligometastatic prostate cancer lesions randomized (1:1) to stereotactic ablative radiation therapy (SABR) versus SBAR + Radium-223. We are looking to determine the progression-free survival of men who have oligometastatic prostate cancer with at least one bone metastasis with stereotactic …

platelet count
neutrophil count
bone metastases
  • 05 Jun, 2022
  • 1 location
FAPI PET for Lung Fibrosis (FAPI ILD)

This is a prospective exploratory biodistribution study in patients with interstitial lung disease (ILD). The purpose of this research study is to determine where and to which degree the FAPI tracer (68Ga-FAPI-46) accumulates in normal and fibrotic lung tissues of patients with interstitial lung disease. The study will include patients …

interstitial lung disease
pulmonary fibrosis
ct scan
  • 30 May, 2022
  • 1 location
PennPET Explorer Scanner Evaluation

Positron Emission Tomography (PET) is a procedure that uses a special type of machine to take pictures of the inside of the body after a radioactive drug is administered. The radioactive drug that is used for this study may be an FDA approved imaging drug or may be used as …

Accepts healthy volunteers
  • 26 Apr, 2022
  • 1 location
Fluorodopa F 18 in Congenital Hyperinsulinism and Insulinoma

Low blood sugars are known to cause brain damage in newborn babies. One of the most common causes of low blood sugars persisting beyond the new born period is a condition called congenital hyperinsulinism (HI). This is a disease whereby the pancreas secretes too much insulin and causes low blood …

  • 23 Jan, 2021
  • 1 location
Parathyroid Allotransplantation in Medically Refractory Hypoparathyroidism (PATH)

Options for treatment of severe, refractory hypocalcemia are limited for the thousands of patients in the United States who suffer from hypoparathyroidism. Parathyroid allotransplantation is an emerging treatment that provides hope for these individuals. Currently, this therapy has only been successfully provided by a few centers in the world. In …

  • 10 Apr, 2022
  • 1 location
FLOW 3 - The Association Between Catheter-based Absolute Coronary Flow and Resistance and 15O-H2O Positron Emission Tomography Scan-based Absolute Myocardial Blood Flow in the Coronary Artery Territory. (FLOW3)

Aims To assess the correlation between absolute flow and resistance assessed by catheter-based thermodilution technique using CoroFlow®-system and myocardial blood flow (MBF) measured by positron emission tomography (PET) and the tracer [15O] labeled water ([15O]H2O) (15O-H2O PET) To assess the correlation between impaired MBF measured with 15O-H2O PET and negative …

angina pectoris
coronary disease
  • 25 Oct, 2022
  • 1 location
Dosimetry of Tc-99m-Tilmanocept

This proposal will use kidney SPECT/CT of Tc-99m-tilmanocept to evaluate the mesangial changes seen in diabetics across the spectrum of kidney disease as well as persons with hypertensive kidney disease, the next most common cause of kidney disease in patients with diabetes. We aim to demonstrate that these different disease …

Accepts healthy volunteers
  • 14 Mar, 2022
  • 1 location
Early Response Evaluation of Proton Therapy by PET-imaging in Squamous Cell Carcinoma Located in the Head and Neck (ERM-PT-HNSCC)

The goal of this project is to develop and characterise an imaging strategy for biology-guided individualisation of the proton therapy plan to improve patient outcome and quality-of-life. Positron-emission tomography (PET) studies reflecting glucose metabolism, hypoxia and physical changes of proton-irradiated tumour tissues will be performed. Patients with head and neck …

  • 19 Apr, 2022
F-18 PSMA for Localization of Parathyroid Adenoma

Parathyroid glands are in the neck and produce a substance called parathormone which maintains the calcium level in the blood. Sometimes one or more of the parathyroid glands become hyperactive and produce too much parathormone which causes increased calcium in the blood which can cause ill effects on multiple parts …

parathyroid adenoma
parathyroid surgery
parathyroid hormones
primary hyperparathyroidism
  • 20 Apr, 2022
  • 3 locations