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Found 47 clinical trials
9-month Study to Assess the Efficacy of Ofatumumab on Microglia in Patients With Relapsing Forms of Multiple Sclerosis

We aim to assess the effect of Ofatumumab on microglial activation using [F-18]PBR06 PET in MS patients in relation to changes in serum markers, MRI abnormalities and clinical impairment longitudinally over 9 months. Specific Aims: Specific Aim 1: To determine the effect of Ofatumumab on microglial activation in MS over …

  • 0 views
  • 04 Aug, 2021
  • 1 location
Study of Nivolumab in Combination w Radium-223 in Men w Metastatic Castration Resistant Prostate Cancer

This is an open label, prospective, trial that begins with a phase Ib safety run-in followed by a phase II expansion cohort.

prostate adenocarcinoma
gilbert's syndrome
bone metastases
neutrophil count
nivolumab
  • 0 views
  • 26 Jan, 2021
  • 1 location
68Ga-HTK03149 for Use as a Diagnostic Radiopharmaceutical

This is a preliminary evaluation of a radiotracer's biodistribution in human subjects. It is a prospective, single-centre, open-label, single group assignment interventional study. Prostate cancer is very common, and PSMA imaging is currently the most accurate means of localizing these tumours. The goal is to evaluate the biodistribution and safety …

  • 0 views
  • 27 Sep, 2021
  • 1 location
68 Ga PSMA PET/MRI for Hepatocellular Carcinoma

This is a pilot study to investigate the evaluate to use of a drug/radiopharmaceutical called Gallium-68 PSMA-11 (68Ga-PSMA-11) for use in PET/MRI evaluation of hepatocellular carcinoma

liver transplant
pet scan
  • 0 views
  • 26 Jan, 2021
Study of 18F-DCFPyL PET/CT Imaging in Patients With Prostate Cancer

This study evaluates the rate of radiological disease progression with the new 2nd generation positron emission tomography (PET) radiopharmaceutical, 18F-DCFPyL, in patients with metastatic

enzalutamide
bone scan
androgen suppression
bilateral orchidectomy
orchiectomy
  • 23 views
  • 13 Mar, 2021
  • 1 location
Cognitive Decline and Alzheimer's Disease in the Dallas Lifespan Brain Study

The investigators will conduct tau positron emission tomography (PET) scans on 125 adults using the radiopharmaceutical Flortaucipir F18 ([18F]AV-1451). This will allow the investigators to

amyloidosis
cognitive decline
flortaucipir
amyloid
oophorectomy
  • 1 views
  • 03 Feb, 2021
  • 1 location
Evaluation of 68-GaNOTA-Anti-HER2 VHH1 Uptake in Brain Metastasis of Breast Carcinoma Patients

This study investigates the uptake of the radiopharmaceutical 68-GaNOTA-Anti-HER2 VHH1 in brain metastasis using PET/CT imaging. Patients with HER2-positive and HER2-negative breast cancer will

carcinoma
her2/neu-negative breast cancer
breast carcinoma
HER2
metastasis
  • 3 views
  • 24 Feb, 2021
  • 1 location
Safety and Targeting of Anti-hk2 Antibody in mCRPC

This is an imaging trial, to develop h11B6 as a therapeutic radiopharmaceutical for men with mCRPC. This imaging study will be conducted to confirm the safety and estimate the mass amount

adenocarcinoma
testosterone
metastasis
androgens
cancer
  • 0 views
  • 18 Apr, 2021
  • 1 location
68Ga-P16-093 and 68Ga-PSMA-617 PET/CT Imaging in the Same Group of Prostate Cancer Patients

metastases, like the widely studied 68Ga-PSMA-617. This pilot study was prospectively designed to evaluate the early dynamic distribution of 68Ga-P16-093, a novel radiopharmaceutical targeting PSMA, which

  • 0 views
  • 22 Mar, 2021
  • 1 location
Assessment of Neuroinflammation in Central Inflammatory Disorders Using [F-18]DPA-714.

The primary objective of this study is to measure the concentration and the regional brain distribution of activated brain microglia/macrophages using the PET radiopharmaceutical [F-18]DPA-714

chronic pain
radiopharmaceutical
benzodiazepines
fibromyalgia
fatigue
  • 554 views
  • 26 Sep, 2021
  • 1 location