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Found 142 clinical trials
Meclizine for Hepatocellular Carcinoma (OPTIM)

Meclizine hydrochloride is an antihistamine widely used for treatment of vertigo and motion sickness. In HCC it has been used for anti-emetic effects, but it is used here as a CAR (constitutive androstane receptor) inverse agonist. The hypothesis of this study is that Meclizine, CAR inverse agonist, will have beneficial …

chemoembolization
measurable disease
ct scan
TACE
  • 19 views
  • 04 Oct, 2022
  • 5 locations
TACE and SBRT Followed by Double Immunotherapy for Downstaging Hepatocellular Carcinoma

This study is a prospective phase II, single arm mono-institutional study conducted in Queen Mary Hospital (Hong Kong) assessing the efficacy and safety of the sequential administration of trans-arterial chemo-embolization (TACE) and stereotactic body radiotherapy (SBRT) with immune checkpoint inhibitors in unresectable hepatocellular carcinoma (HCC) patients.

  • 0 views
  • 11 Aug, 2021
  • 1 location
SBRT and Durvalumab for Inoperable/Unresectable Hepatocellular Carcinoma

The investigators propose a phase II single-arm study on using stereotactic body radiation therapy in combination with durvalumab for inoperable/unresectable hepatocellular carcinoma. In addition, the investigators will also measure the change in number and intensity of PD-L1-positive circulating tumor cells before and after stereotactic body radiation therapy and durvalumab and …

tumor cells
anticoagulants
cancer
serum bilirubin
pet scan
  • 0 views
  • 15 Jun, 2021
  • 1 location
18F-DCFPyL PET/CT in Hepatocellular Carcinoma

Background A radiotracer (or tracer) is a radioactive substance. It is used in Positron Emission Tomography (PET) imaging to help see specific sites in the body. Researchers want to learn if a new tracer can help them better identify hepatocellular cancer (HCC) in people. Objective To learn if a radiotracer …

measurable disease
ct scan
cancer
  • 0 views
  • 21 Oct, 2022
  • 1 location
A Phase II Study of Combined Treatment of Durvalumab, Bevacizumab, Tremelimumab and Transarterial Chemoembolization (TACE) in Subjects With Hepatocellular Carcinoma (HCC) or Biliary Tract Carcinoma (BTC)

Background Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world. Most people with advanced HCC survive an average of 6 to 9 months. Researchers are evaluating a combination of treatment drugs to delay the progression of HCC; aiming to help people with HCC live longer. Objective To …

cancer
TACE
measurable disease
pet scan
EGFR
  • 0 views
  • 23 Oct, 2022
  • 1 location
Nivolumab and Ipilimumab With or Without Local Consolidation Therapy in Treating Patients With Stage IV Non-Small Cell Lung Cancer

This phase III trial studies how well nivolumab and ipilimumab works with or without local consolidation therapy in treating patients with stage IV non-small cell lung cancer. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the …

monoclonal antibodies
carcinoma
lung cancer
lung adenocarcinoma
cancer
  • 53 views
  • 19 Jun, 2022
  • 5 locations
ARAPS Study on Accelerated Liver Regeneration

Liver resection is the golden standard in the treatment of hepatic malignancies. The size and function of the remnant liver is a major concern. If the future liver remnant (FLR) is below 30 % of the initial liver volume, the risk of post hepatectomy liver insufficiency rises. Several techniques have …

  • 0 views
  • 31 Jan, 2021
  • 1 location
Platelet Rich Plasma (PRP) for Facet Mediated Lumbar Low Back Pain

Low back pain (LBP) is both the single most common cause of disability and the leading cause of visits when military personnel go to their primary care doctors. Military personnel that deal with LBP can often be placed on limited duty profile. Not surprisingly, the direct and indirect costs of …

  • 0 views
  • 02 Nov, 2021
  • 1 location
Safety Distance for Endovenous Laser Ablation of the Great Saphenous Vein (SDEVLA)

Chronic venous disease is one of the most common diseases in the western world and worldwide with a prevalence of 83,6%. It is a chronic progressive disease, which causes a significant burden on health systems, treatment and care of these patients. Recurrence of varicose veins after successful treatment remains a …

  • 0 views
  • 06 Feb, 2022
Radiofrequency Ablation for BIII Thyroid Nodules

emerged as a potential alternative to surgery in patients with benign thyroid nodules. Of the myriad ablation methods, the most commonly used technique is radiofrequency ablation (RFA). An expanding body

Accepts healthy volunteers
  • 0 views
  • 21 Mar, 2022
  • 1 location