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Found 5 clinical trials
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Allogeneic Transplantation for Pediatric Leukemias With Unrelated Donors

The study proposes the use of Fludarabine, Busulfan, Anti Thymocyte Globulin Rabbit (ATG) and Total Body Irradiation as a preparative regimen before hematopoietic stem cell transplant

ejection fraction
remission
antithymocyte globulin
total body irradiation
fludarabine
  • 11 views
  • 07 Nov, 2020
  • 1 location
None
A Modified Dose of Rabbit Anti-thymocyte Globulin (rATG) in Children and Adults Receiving Treatment to Help Prepare Their Bodies for a Bone Marrow Transplant

The purpose of this study is to see if conditioning regimens that include personalized rabbit ATG (P-rATG) help the immune system recover sooner and decrease the chances of transplant-related

antithymocyte globulin
total body irradiation
fludarabine
cyclophosphamide
melphalan
  • 0 views
  • 23 Sep, 2021
  • 1 location
None
Provision of TCR T Cells and Memory T Cells Plus Selected Use of Blinatumomab in Na ve T-cell Depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic Malignancies Relapsed or Refractory Despite Prior Transplantation

This study seeks to examine treatment therapy that will reduced regimen-related toxicity and relapse while promoting rapid immune reconstitution with limited serious graft-versus-host-disease (GVHD) and also improve disease-free survival and quality of life. The investigators propose to evaluate the safety and efficacy of selective naive T-cell depleted (by TCR and …

ejection fraction
lymphoma
antithymocyte globulin
colony stimulating factor
fludarabine
  • 189 views
  • 04 Feb, 2021
  • 1 location
None
Treg Modulation With CD28 and IL-6 Receptor Antagonists

The purpose of this study is to evaluate the safety of using lulizumab pegol with tocilizumab, belatacept, and everolimus in kidney transplant recipients.

  • 4 views
  • 06 Mar, 2021
  • 7 locations
None
TCR -depleted Progenitor Cell Graft With Additional Memory T-cell DLI Plus Selected Use of Blinatumomab in Naive T-cell Depleted Haploidentical Donor Hematopoietc Cell Transplantation for Hematologic Malignancies

Patients less than or equal to 21 years old with high-risk hematologic malignancies who would likely benefit from allogeneic hematopoietic cell transplantation (HCT). Patients with a suitable HLA matched sibling or unrelated donor identified will be eligible for participation ONLY if the donor is not available in the necessary time. …

ejection fraction
lymphoma
pulse oximetry
antithymocyte globulin
colony stimulating factor
  • 2 views
  • 19 Oct, 2021
  • 1 location