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Found 23 clinical trials
Fissure Closure With the AeriSeal System for CONVERTing Collateral Ventilation Status (CONVERT) (CONVERT)

This is a prospective, open-label, multi-center, single-arm study to be conducted at up to 15 investigational sites. The Study plans to enroll 140 subjects with severe emphysema and collateral ventilation in the target lobe. This protocol is designed to evaluate the utility of the AeriSeal System to occlude collateral air …

lung volume reduction
  • 26 Mar, 2022
  • 10 locations
OsteoPreP: Food Supplements for Postmenopausal Bone Health (OsteoPreP)

high resolution peripheral quantitative computed tomography [HR-pQCT]) of the distal tibia.

quantitative computed tomography
Accepts healthy volunteers
  • 12 May, 2022
  • 1 location
Skeletal Health and Bone Marrow Composition Among Youth

Children and adolescents experiencing gender dysphoria feel increased distress with the onset of puberty. Gender clinics treat these young adolescents by "blocking" puberty using gonadotropin-releasing hormone (GnRH) agonist medications. This has the possibility of impacting bone development as sex steroids are important to bone mass development. In this multi-site study, …

  • 04 Sep, 2021
  • 1 location
Peanut Protein Supplementation to Prevent Muscle Atrophy and Improve Recovery Following Total Knee Arthroplasty

This randomized controlled trial will study the effects of peanut protein supplementation on changes in muscle size and quality in patients undergoing total knee arthroplasty.

Accepts healthy volunteers
  • 01 May, 2022
  • 1 location
Healthy Body Healthy Bones After Bariatric Surgery Trial

One in three adults in the United States suffers from obesity. Bariatric surgery is an increasingly utilized and effective treatment for obesity and obesity-related comorbidities, however, the massive weight loss associated with bariatric surgery adversely affects bone leads to an increased risk of fracture. Bisphosphonate medications, such as zoledronic acid, …

zoledronic acid
Accepts healthy volunteers
  • 19 Nov, 2021
  • 1 location
Romosozumab to Improve Bone Mineral Density and Architecture in Chronic SCI

Treatment for sublesional bone loss (osteoporosis) in persons with chronic, motor-complete spinal cord injury (SCI) has been limited and unsuccessful to date. Romosozumab, a sclerostin antagonist, has potential to increase bone formation (anabolic) and decrease bone resorption (anti-catabolic) in persons with chronic SCI. Conventional anti-resorptive therapy alone would not be …

spinal cord disorder
spinal cord
  • 29 Apr, 2022
  • 2 locations
The Effect of Inhaled Nitric Oxide on Dyspnea and Exercise Tolerance in COPD (iNO)

Chronic Obstructive Pulmonary Disease (COPD) is a lung disorder commonly caused by smoking, which makes breathing more difficult. When COPD patients exercise, they are not efficient breathers and this leads to serious breathing difficulties, which often causes these patients to stop exercise at low intensities. Even though patients with a …

pulmonary disease
Accepts healthy volunteers
  • 18 Apr, 2022
  • 1 location
Study to Weigh the Effect of Exercise Training on BONE (SWEET-BONE) Quality and Strength in Type 2 Diabetes (SWEET-BONE)

Type 2 diabetes mellitus (T2DM) is associated with increased fracture risk despite normal to increased bone mass, thus suggesting poor bone quality. This study is aimed at weighing the effect of an exercise intervention program on parameters of bone quality in patients with type 2 diabetes mellitus. Two hundred patients …

body mass index
type 2 diabetes mellitus
  • 25 Feb, 2022
  • 1 location

quantitative computed tomography. Physical functioning will be assessed as participants perform a series of physical performance and gait tests. Magnetic resonance images of the lower limbs will be matched-up

Accepts healthy volunteers
  • 24 Feb, 2022
  • 1 location
Skeletal Fragility in Type 1 Diabetes: Glycemic Control and Bone Strength

The purpose of this research study is to find out how bones are affected in children and adolescents with type 1 diabetes (T1D) as compared to children and adolescents without type 1 diabetes.

  • 07 Aug, 2021