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Found 61 clinical trials
Romiplostim Rituximab and Dexamethasone as Frontline Treatment for Immune Thrombocytopenia

The purpose of this study is to determine the response rate and response duration with the combination of low-dose rituximab, romiplostim and high-dose dexamethasone.

rituximab
dexamethasone
romiplostim
platelet count
thrombocytopenia
  • 0 views
  • 25 Jan, 2021
  • 1 location
The Efficacy and Safety of Huaiqihuang Granule in Children With Chronic Primary Immune Thrombocytopenia

This is a multisite, double-blind, randomized, placebo-controlled, and parallel study designed to evaluate the clinical efficacy and safety of Huaiqihuang granule for treatment to children with chronic primary immune thrombocytopenia (Qi Yin deficiency).

huaiqihuang
blood tests
autoimmune thrombocytopenia
anemia
thrombocytopenia
  • 0 views
  • 02 Aug, 2021
  • 14 locations
Eltrombopag vs Standard Front Line Management for Newly Diagnosed Immune Thrombocytopenia (ITP) in Children

This is an investigator initiated, multicenter, open label, randomized phase 3 study for subjects with newly diagnosed ITP from ages 1 to less than 18 years old.

eltrombopag
prednisone
igiv
autoimmune thrombocytopenia
platelet count
  • 10 views
  • 26 Jan, 2021
  • 11 locations
Proof-of-Concept: A Pilot Randomized Double-Blind Study of Oseltamivir Versus Placebo for Immune Thrombocytopenia

Immune Thrombocytopenia (ITP) is a disorder resulting in impaired platelet production and enhanced destruction on the basis of autoantibody-mediated mechanisms. Patients with ITP are at increased risk of bleeding and infection. First line therapy includes glucocorticoids, with or without the addition of intravenous immune globulin (IVIg) when a prompt platelet …

glucocorticoids
prednisone
igiv
autoimmune thrombocytopenia
platelet count
  • 11 views
  • 25 Jan, 2021
  • 1 location
The Combination of ATRA and High-dose Dexamethasone as First-line Treatment in Adult Immune Thrombocytopenia

Randomized, open-label, multicenter study to compare the efficacy and safety of ATRA plus high-dose dexamethasone compared to high-dose dexamethasone monotherapy for the first-line treatment of adults with primary immune thrombocytopenia (ITP).

atra
dexamethasone
autoimmune thrombocytopenia
platelet count
thrombocytopenia
  • 17 views
  • 26 Jan, 2021
  • 1 location
The Safety Tolerability Pharmacokinetics and Preliminary Efficacy of HMPL-523 in Immune Thrombocytopenia Patients

This is a randomized, double blinded, placebo-controlled phase Ib clinical trial in adult patients with immune thrombocytopenia. Cross-over treatment will be allowed during the study.

treatment regimen
splenectomy
anemia
thrombocytopenia
  • 7 views
  • 26 Jan, 2021
  • 1 location
A Study to Assess Efficacy and Safety of Eltrombopag in Combination With a Short Course of Dexamethasone in Patients With Newly Diagnosed ITP

The purpose of this study is to compare the ability of eltrombopag in combination with a short course of high-dose dexamethasone to induce sustained response off treatment in patients with newly-diagnosed ITP versus 1-3 cycles of dexamethasone monotherapy. The unmet clinical need and the potential for eltrombopag when added to …

dexamethasone
platelet count
eltrombopag
  • 20 views
  • 19 Aug, 2021
  • 21 locations
Eltrombopag Plus rhTPO Versus Eltrombopag for ITP During the COVID-19 Pandemic (ELABORATE-19)

This is a prospective, multicenter, randomized, open-label study to investigate the efficacy and safety of eltrombopag plus recombinant human thrombopoietin (rhTPO) versus eltrombopag as treatment for corticosteroid-resistant or relapsed immune thrombocytopenia (ITP) during the COVID-19 pandemic.

corticosteroids
recombinant human thrombopoietin
covid-19
eltrombopag
autoimmune thrombocytopenia
  • 0 views
  • 25 Jan, 2021
  • 1 location
Fixed Low-dose Eltrombopag and rhTPO for Immune Thrombocytopenia (FLOWER)

This is a prospective, single-arm study to investigate the efficacy and safety of the combination of fixed low-dose eltrombopag plus recombinant human thrombopoietin (rhTPO) as treatment for corticosteroid-resistant or relapsed immune thrombocytopenia (ITP) patients during the COVID-19 pandemic.

corticosteroids
recombinant human thrombopoietin
covid-19
eltrombopag
autoimmune thrombocytopenia
  • 0 views
  • 26 Jan, 2021
  • 1 location
Open-label Study Measuring Safety and Treatment Satisfaction in Adult Subjects With Chronic Immune Thrombocytopenia (ITP) After Switching to Avatrombopag From Eltrombopag or Romiplostim

Evaluate the safety and tolerability of avatrombopag given for 90 days after stopping treatment with eltrombopag or romiplostim.

romiplostim
avatrombopag
thrombocytopenia
eltrombopag
  • 0 views
  • 17 Sep, 2021
  • 5 locations