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Found 23 clinical trials
Hypoglycemia Associated Autonomic Failure in Type 1 Diabetes Mellitus (DM)

Exercise is a cornerstone of diabetes management. It helps reduce blood pressure, promote weight loss, lower insulin resistance and improve glucose and lipid (triglyceride and HDL-cholesterol) profiles. Unfortunately, the benefits of exercise are often not embraced by diabetic individuals because of the fear of low blood sugar (hypoglycemia). My laboratory …

insulin
neuropathy
sugars
hypoglycemia
Accepts healthy volunteers
  • 221 views
  • 27 Apr, 2022
  • 1 location
CPAP for the Treatment of Supine Hypertension

This study aims to learn about the effects of continuous positive airway pressure (CPAP) on people with autonomic failure and high blood pressure when lying down (supine hypertension) to

systolic blood pressure
orthostatic hypotension
pure autonomic failure
hypertension
  • 0 views
  • 04 Oct, 2022
  • 1 location
Randomized Double-Blind Placebo-Controlled Adaptive Design Trial Of Intrathecally Administered Autologous Mesenchymal Stem Cells In Multiple System Atrophy

Multiple system atrophy (MSA) is a rare, rapidly progressive, and invariably fatal neurological condition characterized by autonomic failure, parkinsonism, and/or ataxia. There is no available

ataxia
parkinsonism
  • 0 views
  • 24 Mar, 2022
  • 1 location
Multicenter Implementation of E-monitoring in Parkinson's Disease (EPD)

falls, but also sleep disturbance, cognitive decline, behavioral problems and autonomic failure. These symptoms often fluctuate over time and between patients. These fluctuating and often debilitating

motor symptoms
tremor
movement disorder
cognitive decline
bradykinesia
  • 2 views
  • 14 Jun, 2022
  • 6 locations
Quality of Life of Caregivers and Patients Suffering From Multiple System Atrophy (QUA2-AMS)

Multiple system atrophy (MSA) is a rare and fatal neurodegenerative disorder that cause as other neurodegenerative diseases profound declines in functioning and thus, require caregiving for assistance with daily living. The aim of the study is to evaluate the effect of a multimodal intervention as proposed by the NYU Caregiver …

Accepts healthy volunteers
  • 1 views
  • 25 Jan, 2022
  • 1 location
Restoration of Hypoglycemia Awareness With Metoclopramide

Metoclopramide is a drug approved by the FDA for gastroesophageal reflux and to relieve symptoms in adults with acute and recurrent diabetic gastroparesis. The objective of this study is to determine whether metoclopramide can improve hypoglycemia awareness and decrease the incidence of hypoglycemia in type 1 diabetes patients with hypoglycemia …

  • 43 views
  • 17 Oct, 2022
  • 1 location
Hypercapnia in Orthostatic Hypotension

The Autonomic (or "automatic") Nervous System (ANS) regulates internal processes, including control of heart rate and blood pressure (BP). When someone stands, and gravity tries to pull blood away from the brain, the ANS works to maintain BP and brain blood flow. Neurogenic Orthostatic Hypotension (NOH) occurs when our "fight-or-flight" …

Accepts healthy volunteers
nervous
light-headedness
  • 0 views
  • 08 Apr, 2022
  • 1 location
Sporadic Degenerative Ataxia With Adult Onset: Natural History Study

The key goals of SPORTAX-NHS is to compare the phenotype of multiple system atrophy of cerebellar type (MSA-C) and sporadic adult onset ataxia of unknown aetiology (SAOA) and to determine the rate of disease progression in both groups including determination of the factors that predict the development of MSA-C vs. …

  • 59 views
  • 21 Jan, 2021
  • 17 locations
The Role of Sympathetic Tone Regarding the Anatomical and Functional Recovery of the Left Ventricle in TakoTsubo Syndrome

TakoTsubo Syndrome (TTS) constitutes an increasingly recognised, heterogenous clinical entity which is associated with considerable short-term mortality. In addition, emerging evidence suggests that, in the long term, TTS can induce the expression of a phenotype similar to HFpEF . Apart from the typical (apical left ventricular) type, the current TTS …

  • 0 views
  • 28 Jan, 2021
  • 1 location
Natural History Study of Synucleinopathies

Synucleinopathies are a group of rare diseases associated with worsening neurological deficits and the abnormal accumulation of the protein α-synuclein in the nervous system. Onset is usually in late adulthood at age 50 or older. Usually, synucleinopathies present clinically with slowness of movement, coordination difficulties or mild cognitive impairment. Development …

atrophy
orthostatic hypotension
multiple system atrophy
dizziness
sexual dysfunction
  • 768 views
  • 25 Jan, 2022
  • 8 locations