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Found 23 clinical trials
MotIoN aDaptive Deep Brain Stimulation for MSA (MINDS)

Patients routinely undergo deep brain stimulation (DBS) for treatment of symptoms related to neurodegenerative conditions, most commonly Parkinson's disease. In the Investigator's experience, and published evidence shows, that stimulation has effects on the autonomic nervous system. In patients undergoing therapeutic DBS for a particular subtype of Parkinsonism (Multiple System Atrophy), …

parkinson's disease
parkinsonism
  • 0 views
  • 25 Mar, 2022
  • 1 location
Treatment of Supine Hypertension in Autonomic Failure (CPAP)

Supine hypertension is a common problem that affects at least 50% of patients with primary autonomic failure. Supine hypertension can be severe and complicates the treatment of orthostatic

orthostatic hypotension
hypertension
cpap
  • 3 views
  • 04 Oct, 2022
  • 1 location
[18F]F-DOPA Imaging in Patients With Autonomic Failure

), Multiple System Atrophy (MSA), Dementia with Lewy Bodies (DLB). Common to these disorders are the involvement of the central and peripheral autonomic nervous system, where Pure Autonomic Failure (PAF) is

dopa
nervous system disorder
entacapone
demented
alpha-synuclein
  • 19 views
  • 01 May, 2022
  • 1 location
Effect of Raised Head of the Bed on Lying Blood Pressure in Autonomic Failure

Many persons with autonomic failure often have high blood pressure when lying down (supine hypertension). This study is exploring the impact of decreased venous return to the heart (achieved by

hypertension
  • 6 views
  • 04 Oct, 2022
  • 1 location
Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure

the veins of the abdomen of patients with autonomic failure. The study will be conducted at Vanderbilt University Medical Center, and consists of 2 parts: a screening and 2 testing days. The total

midodrine
systolic blood pressure
orthostatic hypotension
parkinson's disease
pure autonomic failure
  • 273 views
  • 16 Jun, 2022
  • 1 location
Overnight Trials With Heat Stress in Autonomic Failure Patients With Supine Hypertension

Patients with autonomic failure are characterized by disabling orthostatic hypotension (low blood pressure on standing), and at least half of them also have high blood pressure while lying down

orthostatic hypotension
multiple system atrophy
hypertension
parkinson's disease
pure autonomic failure
  • 174 views
  • 25 Mar, 2022
  • 1 location
Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure Patients

The purpose of this study is to learn more about the effects of abdominal compression and the medication midodrine, two interventions used for the treatment of orthostatic hypotension (low blood pressure on standing), on hemodynamic markers of cardiovascular risk. The study will be conducted at the Vanderbilt University Medical Center …

orthostatic hypotension
systolic blood pressure
pure autonomic failure
midodrine
  • 0 views
  • 19 Jun, 2022
  • 1 location
Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure

Compression garments have been shown to be effective in the treatment of orthostatic hypotension in autonomic failure patients. The purpose of this study is to determine the hemodynamic

midodrine
stroke
multiple system atrophy
orthostatic hypotension
parkinson's disease
  • 107 views
  • 04 Oct, 2022
  • 1 location
Use of Accelerometer for Quantification of Neurogenic Orthostatic Hypotension Symptoms

The objective of this study is to find a more objective and accurate way to assess the efficacy of the treatment for neurogenic orthostatic hypotension. For this purpose, the investigators will use an activity monitor to determine the amount of time patients spend in the upright position (standing and walking; …

midodrine
systolic blood pressure
orthostatic hypotension
parkinson's disease
pure autonomic failure
  • 50 views
  • 25 Jan, 2022
  • 1 location
Automated Abdominal Binder for Orthostatic Hypotension

The automated inflatable abdominal binder is an investigational device for the treatment of orthostatic hypotension (low blood pressure on standing) in patients with autonomic failure. The

midodrine
systolic blood pressure
orthostatic hypotension
pure autonomic failure
atrophy
  • 18 views
  • 04 Oct, 2022
  • 1 location