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Found 29 clinical trials
Safety and Efficacy of Subcutaneous Sarilumab in Improving the Quality of Life in People With Indolent Systemic Mastocytosis

days. They will: Be assigned to get either the study drug or a placebo. They will not know which one they get. Have a skin punch biopsy: An instrument will remove a small piece

  • 29 Jun, 2022
  • 1 location
Genomic Responses of Human Immune and Non-Immune Cells to Glucocorticoids

Background The immune system defends the body against bacteria and other harmful invaders. But it can overact and attack healthy cells by mistake. The group of drugs called glucocorticoids (GCs) can calm down an overactive immune system. But they often cause negative side effects. Researchers want to learn how human …

Accepts healthy volunteers
  • 28 Jun, 2022
  • 1 location
Intralesional 5-Fluorouracil (5FU), Topical Imiquimod Treatment for SCC

This clinical trial proposes to evaluate a relatively unexplored approach to treatment of squamous cell carcinoma (SCC) on the lower extremities. The strategy is to directly and specifically deliver drug to the tumor. For the proposed phase I clinical trial, the investigators will perform intralesional injections of a well characterized, …

Accepts healthy volunteers
  • 12 Feb, 2022
  • 1 location
Immediate Suture or Directed Wound Healing? Comparative Study of Their Respective Values Following a Punch Skin Biopsy (CICAT)

The skin punch-biopsies are frequently used technical acts in the current medical practice. However, while these skills are actually easy to perform, the subsequent healing procedure remains still poorly harmonized. Indeed, it usually depends on the physicians personal experiences and some preconceived considerations without any reliable scientific background. This study …

  • 31 Mar, 2021
  • 1 location
Percutaneous Punch Biopsy for Diagnosis of Septic and Aseptic Prosthetic Joint Failure

The aim of the superiority study is to establish a reproducible, minimally invasive, cost-effective way of sample collection for microbiological and pathomorphological processing in a clinical setting with avoidance of anesthesia, multiple punctures, as well as potential deep contamination during irrigation.

  • 26 Jan, 2021
  • 1 location
Inforatio Technique to Promote Wound Healing of Diabetic Foot Ulcers

group. The definition of inforatio technique is application of small cuts in wound beds with punch biopsy tools without involving surrounding epithelia. The aim is to initiate an acute inflammatory

  • 23 Apr, 2022
  • 1 location
MoleMapper, Visiomed, and Confocal Microscopy in Screening Participants for Melanoma

This trial studies how well MoleMapper, Visiomed, and confocal microscopy work in screening participants for melanoma. Analyzing images (photographs) made with three different portable imaging systems may be as good as a visit to a dermatologist's office for finding melanomas before they can spread.

Accepts healthy volunteers
shave biopsy
skin lesion
skin cancer
  • 19 Apr, 2022
  • 1 location
Mepolizumab for the Treatment of Chronic Spontaneous Urticaria

This is an exploratory study designed to generate preliminary data in evaluating the efficacy of Nucala in the treatment of chronic spontaneous urticaria.

antihistamine therapy
  • 06 May, 2022
  • 1 location
Probiotics for Improving Post-surgical Healing

A randomized, double-blind, placebo-controlled clinical trial will be performed to assess the efficacy of a probiotic containing Lactobacillus reuteri in improving post-surgical wound healing after impacted tooth extractions. The Primary aim is to evaluate the efficacy of L. reuteri in improving post-extractive healing. The Secondary aim is to evaluate the …

  • 04 Jun, 2021
  • 1 location
Histology Study of Biostimulatory Activity of Injectable Poly-L-Lactic Acid (Sculptra Aesthetic)

The study device, Sculptra, is an injectable implant formulation of poly-L-lactic acid microbeads, approved by the FDA for treatment of facial fat loss (lipoatrophy of HIV disease). It is being used off-label by dermatologists to treat dermal defects, as a biologically active filler. Anecdotal evidence suggests that subjects' skin quality …

  • 19 Aug, 2021
  • 1 location