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Found 130 clinical trials
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SEvoflurane for Sedation in ARds

This study evaluates whether a sedation with inhaled sevoflurane will decrease mortality and increase time off the ventilator at 28 days in patients with acute respiratory distress syndrome (ARDS). Half of the patients will receive inhaled sedation with sevoflurane and the other half will receive intravenous sedation with propofol.

acute respiratory distress
respiratory symptom
edema
shock
positive end expiratory pressure
  • 0 views
  • 04 Sep, 2021
  • 24 locations
None
Effect of Automated Closed-Loop Ventilation Versus Conventional Ventilation on Duration and Quality of Ventilation

INTELLiVENT-Adaptive Support Ventilation (ASV) is a fully automated closed-loop mode of mechanical ventilation available on commercial ventilators. Evidence for clinical benefit of INTELLiVENT-ASV in comparison to non-automated ventilation is lacking. The ACTiVE study is an international, multicenter, randomized controlled trial in invasively ventilated ICU patients with the objective to compare …

  • 0 views
  • 25 Jan, 2021
  • 13 locations
None
Transcutaneous Carbon-dioxide Monitoring in Electrophysiological Procedures in Deep Sedation

Complex procedures for treatment of cardiac arrhythmias are usually performed under deep sedation, since a quiet position of the patient is usually required over several hours and a significant risk of injury is caused by unconsciously movements of the patient. The sedative medication inhibits respiration. This can result in an …

  • 0 views
  • 25 Jan, 2021
  • 1 location
None
Efficacy and Safety Profile of Remimazolam-alfentanil Combination for ERCP Sedation

Moderate to deep levels of sedation and analgesia are required for ERCP. Propofol-based sedation is simple, easy to use, and effective, but is not without cardiovascular and respiratory adverse effects. The combination of remimazolam and alfentanil has shown promising results for sedation in other similar scenarios. The aim of this …

propofol
analgesia
intubation
  • 0 views
  • 03 Jul, 2021
  • 1 location
None
Early Femoral Block in Elderly With Hip Fracture

Assess if the addition of an early femoral nerve block (performed within 2 hours from the admission in emergency department through a femoral nerve catheter) in the elderly patients (> 70 years) with hip fracture, reduces the incidence of postoperative delirium assessed by CAM 3Ds test, compared to the traditional …

nerve block
delirium
analgesia
femoral neck fracture
  • 0 views
  • 24 Jan, 2021
  • 1 location
None
Combined Spinal-epidural Anesthesia for Cesarean Section Without Prophylactical Prehydration and Vasopressors

Hypotension is a common complication in pregnant women after spinal anesthesia and related with the dose of local anesthetic. Injecting small dose local anesthetic into subarachnoid space can decrease the incidence of hypotension, but increase the risk of incomplete analgesia and muscle relaxation. The investigators hypothesize there is an optimal …

local anesthetic
local anesthetics
local anesthesia
anesthesia
analgesia
  • 10 views
  • 26 Jan, 2021
  • 1 location
None
SI + CC Versus 3:1 C:V Ratio During Neonatal CPR

Research question In newborn infants requiring CPR, does CC superimposed by sustained inflation compared to 3:1 compression to ventilation ratio improves return of spontaneous circulation? Overall objective: CC superimposed by sustained inflation will improve short- and long-term outcomes in preterm (>28 weeks or older) and term newborns. Hypothesis to be …

  • 330 views
  • 12 Sep, 2021
  • 22 locations
None
Study to Evaluate the Efficacy & Safety of the INTERCEPT Blood System for RBCs in Complex Cardiac Surgery Patients

The objective of this study is to evaluate the efficacy and safety of RBC transfusion for support of acute anemia in cardiovascular surgery patients based on the clinical outcome of renal impairment following transfusion of red blood cells (RBCs) treated with the INTERCEPT Blood System (IBS) for Red Blood Cells …

red blood cell transfusion
blood transfusion
anemia
  • 12 views
  • 04 Jun, 2021
  • 16 locations
None
SpO2 Accuracy In Vivo Testing for Neonates & Infants

The purpose of this clinical study is to validate the oxygen saturation (SpO2) accuracy of various pulse oximetry systems and sensors (new designs and/or reprocessed) during non-motion

  • 0 views
  • 30 Apr, 2021
  • 2 locations
None
  • 0 views
  • 08 Sep, 2021
  • 1 location