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Found 3 clinical trials
Impact of Discontinuing Chronic Therapies in People With Cystic Fibrosis on Highly Effective CFTR Modulator Therapy

therapies can be safely stopped. The SIMPLIFY study is being done to test whether or not it is safe to stop taking inhaled hypertonic saline or Pulmozyme (dornase alfa) in those people that are also taking

forced expiratory volume
elexacaftor
cystic fibrosis transmembrane conductance regulator
tezacaftor
fibrosis
  • 55 views
  • 26 Jan, 2021
  • 74 locations
Pulmozyme to Improve COVID-19 ARDS Outcomes

This is a randomized double-blind placebo-controlled Phase II trial of recombinant human deoxyribonuclease I (rhDNase I) - Pulmozyme - in mechanically ventilated patients with COVID-19 pneumonia

respiratory distress
mechanical ventilation
covid-19
acute respiratory distress
pneumonia
  • 0 views
  • 18 Apr, 2021
  • 1 location
Improving Outcome Measures For Adult CF ACT Trials

This is a randomised controlled cross-over trial involving adult cystic fibrosis (CF) patients from the Royal Brompton Hospital, London investigating outcome measures used in airway clearance trials. Each participant will attend the research facility for two visits. Participants will be randomly assigned to the order that they perform the study …

lung clearance index
fibrosis
spirometry
  • 3 views
  • 01 Aug, 2021
  • 1 location