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Found 75 clinical trials
Environmental Risk Factors for the Anti-synthetase Syndrome

Background Like other complex diseases, autoimmune diseases are the result of numerous causes, including genetic and environmental factors. Some researchers believe that people who are susceptible to autoimmune disorders develop them when the body reacts to environmental or other factors by creating white blood cells that attack the body s …

pulmonary disease
autoimmune disease
myositis
house dust
chest x-ray
  • 142 views
  • 16 Jun, 2022
  • 2 locations
Lung Function, Exercise Capacity and Health-Related Quality of Life After Severe COVID-19

Coronavirus disease 2019 (COVID-19) is a respiratory tract infection caused by a newly emergent coronavirus (SARS-CoV-2) that can progress to severe disease requiring hospitalization and oxygen support in around14% of the cases and 5% require admission in intensive care unit. The medium and long-term impact in survivors of severe COVID-19 …

pneumonia
fever
respiratory distress
FIO2
pao2
  • 0 views
  • 04 Jun, 2022
  • 2 locations
Molecular Diagnosis of Idiopathic Interstitial Pneumonias: a Prospective Study

Molecular diagnosis of idiopathic interstitial pneumonias is an innovative way to potentially improve the diagnostic accuracy of surgical lung biopsies (SLBs), introducing molecular classifiers of idiopathic pulmonary fibrosis (IPF) vs. non-specific interstitial pneumonia (NSIP), the 2 main types of idiopathic interstitial pneumonias (IIPs). The investigators hypothesize that pre-defined gene expression …

pulmonary disease
pneumonia
lung biopsy
ct scan
connective tissue disease
  • 26 views
  • 07 Feb, 2022
  • 1 location
Small Airways Disease (SAD) in Severe Asthma as a Novel Endpoint and Distinct Target for Mepolizumab (SASAM Study)

Rationale Although the majority of asthma patients can be effectively treated with currently available medications, a substantial subset remains severe, causing a considerable proportion of resource expenditure. Severe asthma is now widely accepted to be a heterogeneous syndrome consisting of multiple phenotypes identified by specific biomarkers and targeted by tailored …

  • 0 views
  • 17 Sep, 2021
  • 1 location
ILD-SARDs Registry and Biorepository

A complex interaction between demographic, environmental and genetic mechanisms impact the onset, severity and outcome of ILD-SARDs through dysregulation of the immune system and lung pro-biotic pathways. Comorbidity and genetic risk indicate that there are overlapping pathogenic mechanisms among SARDs, some of which underlie ILD in different SARDs. The purpose …

connective tissue disease
bronchoalveolar lavage
chest ct
lung disease
  • 0 views
  • 18 Sep, 2021
  • 1 location