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Found 67 clinical trials
Breath Condensate Study in Patients With Cystic Fibrosis.

There is an urgent need for a noninvasive method to diagnose bronchial infections and exacerbations in patients with Cystic Fibrosis (CF). The current method to diagnosed infections involves either collecting a sputum sample or obtaining a bronchoalveolar lavage (BAL). However, some patients cannot produce sputum. At the same time the …

  • 25 Jan, 2021
  • 1 location
Upper Extremity Exercise Capacity Muscle Oxygenation Balance in Patients With Cystic Fibrosis

The primary aim of the study is to evaluate upper extremity exercise capacity, muscle oxygenation, balance and physical activity level in patients with cystic fibrosis.. The secondary aim of the study is assessment of functional exercise capacity, respiratory function, peripheral and respiratory muscle strength, respiratory muscle endurance, quality of life …

  • 16 May, 2021
  • 2 locations
Clinical Molecular and Imaging Biomarkers in Spinal and Bulbar Muscular Atrophy (SBMA)

Background SBMA is an inherited chronic disease. It affects males in mid to late adulthood. It causes slowly progressive weakness of muscles and hand tremors. Researchers want to learn more about the effects of SBMA. Objective To identify measurements that change over time in SBMA, including tests of muscle strength …

motor neuron disease
spinal and bulbar muscular atrophy
  • 22 Sep, 2021
  • 1 location
Vascular Implications of a Naturally Occurring Asthma Exacerbation

Although asthma is a disease of the airways, research is now showing that asthmatics are more likely to develop cardiovascular disease (CVD) compared to non-asthmatics. Vascular dysfunction is seen in people at high risk of CVD and has been linked to inflammation. During an asthma attack, levels of inflammation in …

cardiovascular disease
asthma attack
  • 18 Apr, 2021
  • 3 locations
Alpha-1 Antitrypsin Deficiency Adult Liver Study

The investigators hypothesize that there is liver injury (inflammation, fibrosis, cirrhosis) in adults with Alpha-1 Antitrypsin Deficiency (AATD), which is asymptomatic, under-recognized, and undiagnosed. In addition, the investigators believe that the genetic and environmental factors that play an important role in the development of alpha-1 antitrypsin (AAT) liver disease, can …

liver study
alpha1-proteinase inhibitor (human)
liver injury
  • 11 Mar, 2021
  • 3 locations
Implication of UNconventionaL T Lymphocytes in Cystic Fibrosis (UNLOCk)

Cystic fibrosis (CF) is characterized by a decrease in mucociliary clearance, recurrent infections and airway inflammation. This inflammatory process in airway mucosa is persistent, uncontrolled, but, somewhat paradoxically, ineffective for pathogen clearance. Neutrophils are chronically recruited in the airway mucosa by proinflammatory mediators such as Interleukin (IL)-17. However, mechanisms involved …

  • 11 May, 2021
  • 2 locations
Renal- and Pulmonary Function in Relation to Abdominal Hypertension After Abdominal Reconstruction

An incisional hernia is technically challenging to operate and is the most frequent long-term complication after open surgery, resulting in impaired quality of life and reduced physical ability. Large hernias contain large amounts of abdominal volume, which similarly are missing from the abdominal cavity. Due to adaptations of the abdominal …

incisional hernia repair
blood tests
renal injury
  • 24 Jan, 2021
  • 1 location